JULIO FLAVIO MEIRELLES MARCHINI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
LIM/51 - Laboratório de Emergências Clínicas, Hospital das Clínicas, Faculdade de Medicina
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bookPart Emergências hipertensivas(2020) RODRIGUES, Caio Godoy; MARCHINI, Júlio Flávio Meirelles; BRANDãO NETO, Rodrigo Antonio- Biomarker-associated Monocyte Inflammatory Signaling in Myocardial Infarction(2023) GUIMARÃES, Raphael Boesche; MARCHINI, Julio; GOMEZ, Luz Marina; LEITE, Rogério Sarmento; DUTRA, Oscar; CASTRO, Iran; MANICA, André LuizAbstract Background: Monocytes are essential components in inflammatory signaling, and their recruitment is crucial in the signaling pathway, which directs and determines cell adhesion to the activated endothelium. A better understanding of the correlation between monocyte subsets and inflammatory signaling in patients with atherosclerotic disease in acute coronary syndrome (ACS) is essential for the development of more effective therapies for the prevention and treatment of cardiovascular diseases. Objective: To analyze differences between biomarkers and monocyte activation in the setting of ischemic heart disease. Methods: This was a case-control study comparing biomarkers and monocyte subsets between patients with ACS with and without ST-segment elevation and individuals without coronary stenosis. The nonparametric Kruskal-Wallis test was used to assess differences between groups, and Dunn's post hoc test was used to identify which groups were different. Cuzick's test for ordered group trends was used to assess falling or rising trends. Participants were classified into 3 groups: control (0); non-ST-elevation myocardial infarction (NSTEMI) (1); ST-elevation myocardial infarction (STEMI) D1 (2). Results: Forty-seven patients with ACS and 19 controls with no obstructive lesions on coronary angiography were recruited. Monocyte profile assessment was statistically different regarding time of symptom onset and the presence or absence of atherosclerotic disease (Kruskal-Wallis, p = 0.0009). Dunn's post hoc test showed a significant difference between the control group and the STEMI D1 (p = 0.0014), STEMI D3 (p = 0.0036), and STEMI D7 (p = 0.0195) groups, corresponding to a 2-fold increase in classical (p = 0.0022) and nonclassical (p = 0.0031) monocytes compared with controls. For classical monocytes, there was a difference between the control group and all STEMI groups and between the NSTEMI group and the STEMI D1, D3, and D7 groups. For nonclassical monocytes, there was a difference between the control group and the STEMI D7 group (p = 0.0056) and between the NSTEMI group and the STEMI D7 group (p = 0.0166). Conclusion: This study found that there was an increase in total and classical monocyte mobilization at the time of acute myocardial infarction in patients with ACS.
bookPart Cólica nefrética(2018) MARCHINI, Julio Flávio Meirelles; BRANDãO NETO, Rodrigo AntoniobookPart Emergências hipertensivas(2022) MARCHINI, Julio Flávio Meirelles; ALENCAR, Júlio César Garcia de; BARROSO, Patrícia PerezbookPart Endocardite infecciosa(2019) BRANDãO NETO, Rodrigo Antonio; MACHADO, Adriano da Silva; MARCHINI, Julio Flávio MeirellesbookPart Fibrilação atrial(2019) MARCHINI, Julio Flávio Meirelles; BRANDãO NETO, Rodrigo AntoniobookPart Acidentes por animais peçonhentos(2018) MARCHINI, Julio Flávio MeirellesbookPart Via aérea nas emergências hipertensivas(2023) VAISBERG, Victor Van; MARCHINI, Julio Flavio Meirelles; ALENCAR, Júlio César Garcia debookPart Emergências hipertensivas(2019) RODRIGUES, Caio Godoy; MARCHINI, Julio Flávio Meirelles; BRANDãO NETO, Rodrigo AntoniobookPart Infecções de vias aéreas superiores(2021) MARCHINI, Júlio Flávio Meirelles; BRANDãO NETO, Rodrigo Antonio