RAFAEL HADDAD ASTOLFI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
1 resultados
Resultados de Busca
Agora exibindo 1 - 1 de 1
- Is Gilbert Syndrome a new risk factor for breast cancer?(2011) ASTOLFI, Rafael Haddad; BUGANO, Diogo Diniz Gomes; FRANCISCO, Alice Aparecida Rodrigues Ferreira; SOUZA, Marcelo Moreira Tavares de; ONO-NITA, Suzane Kioko; BARACAT, Edmund ChadaPatients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.