MARCELO MOREIRA TAVARES DE SOUZA
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental, Hospital das Clínicas, Faculdade de Medicina
2 resultados
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- Is Gilbert Syndrome a new risk factor for breast cancer?(2011) ASTOLFI, Rafael Haddad; BUGANO, Diogo Diniz Gomes; FRANCISCO, Alice Aparecida Rodrigues Ferreira; SOUZA, Marcelo Moreira Tavares de; ONO-NITA, Suzane Kioko; BARACAT, Edmund ChadaPatients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.
- Genetic Risk for Alcoholic Chronic Pancreatitis(2011) COSTA, Marianges Zadrozny Gouvea da; GUARITA, Dulce Reis; ONO-NITA, Suzane Kioko; PARANAGUA-VEZOZZO, Denise Cerqueira; FELGA, Guilherme Eduardo Goncalves; PEDROSO, Martha Regina Arcon; SOUZA, Marcelo Moreira Tavares de; NASSER, Paulo Dominguez; FERREIRA, Camila da Silva; CARRILHO, Flair JoseIn recent years many studies have examined the genetic predisposition to pancreatic diseases. Pancreatic disease of an alcoholic etiology was determined to be a multi-factorial disease, where environmental factors interact with the genetic profile of the individual. In this review we discuss the main results from studies examining the frequency of genetic mutations in alcoholic chronic pancreatitis.