BRUNO DE CASTRO E SOUZA
Índice h a partir de 2011
2
Projetos de Pesquisa
Unidades Organizacionais
13 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 13
- Analysis of clonal immunoglobulin chain gene rearrangement by the technique of polymerase chain reaction (PCR) to aid in the diagnosis of B-cell cutaneous lymphoproliferative processes(2023) GUIMARAES, Adriana Borba; SANCHES JUNIOR, Jose Antonio; ZERBINI, Maria Claudia; MIYASHIRO, Denis Ricardo; CURY-MARTINS, Jade; PEREIRA, Juliana; CULLER, Hebert Fabricio; CASTRO, Bruno
- Cutaneous metastases from solid neoplasms - Literature review(2023) SOUZA, Bruno de Castro e; MIYASHIRO, Denis; PINCELLI, Marcella Soares; SANCHES, Jose AntonioCutaneous metastases from solid tumors are uncommon events in clinical practice. Most of the time, the patient already has the diagnosis of a malignant neoplasm when the cutaneous metastasis is detected. However, in up to one-third of cases, cutaneous metastasis is identified before the primary tumor. Therefore, its identification may be essential for starting treatment, although it is usually indicative of poor prognosis. The diagnosis will depend on clinical, histopathological, and immunohistochemical analysis. Sometimes the identification of the primary site is difficult; however, a thorough analysis using imaging tests and constant surveillance is important. (c) 2023 Sociedade Brasileira de Dermatologia.
- Immune-Mediated Necrotizing Myositis Presenting with Cutaneous Lesions(2021) SOUZA, Bruno de Castro e; FASCIANI, Isaura A.; SWICZAR, Bethania C. C.; MENDONCA, Rodrigo de H.; VALENTE, Neusa Y. S.
- Clear Cell Porocarcinoma Arising in an Epidermodysplasia Verruciformis Patient(2021) SOUZA, Bruno de Castro e; VALENTE, Neusa Yuriko Sakai; TYRING, Stephen; OLVEIRA, Walmar Roncalli Pereira de
- Different aspects and variants of mycosis fungoides in a single patient(2021) SOUZA, Bruno Castro; MIYASHIRO, Denis; GIANNOTTI, Marcelo Abrantes; SANCHES, Jose Antonio
- Systemic amyloidosis manifestation in a patient with psoriatic arthritis(2021) SOUZA, Bruno de Castro e; GAVIOLI, Camila Fatima Biancardi; OLIVEIRA, Walmar Roncalli Pereira de; ROMITI, RicardoSystemic amyloidosis secondary to psoriatic arthritis is rare, and published data are based mainly on case reports and are associated with increased mortality. This is the report of a patient with long-term psoriatic arthritis and chronic sialadenitis, who showed an inadequate response to therapy. The diagnosis of secondary amyloidosis was attained through biopsies of genital skin lesions. Although very rare, it is important that dermatologists and general practitioners consider the possibility of amyloidosis in patients with chronic inflammatory diseases, since an early intervention can be implemented, and thus, the prognosis of this condition can be improved. (c) 2021 Sociedade Brasileira de Dermatologia.
- Immunosuppressant-induced cutaneous drug reactions in solid organ transplant recipients(2021) MIOTTO, Isadora Zago; SOUZA, Bruno de Castro e; TYRING, Stephen K.; OLIVEIRA, Walmar Roncalli Pereira deSolid organ transplant recipients (SOTRs) are susceptible to various cutaneous side effects as a consequence of long-term immunosuppressive therapy. Skin cancers and infections are well-studied complications that can cause death and/or allograft rejection. Other cutaneous drug reactions, such as inflammatory manifestations, have a high prevalence but are rarely studied. We analyzed these manifestations' prevalence and their association with immunosuppressants in transplant recipients from a Brazilian tertiary center. Among 532 SOTRs followed at our dermatology clinic, 60 (11.3%) developed some cutaneous adverse reactions to the immunosuppressants, with a median age at transplantation of 50.5 years and a median life span posttransplantation of seven years. Acneiform eruption was the most common drug reaction found (21 patients, 30.4%), followed by diffuse non-scarring alopecia (16 patients, 23.1%), lymphedema (10 patients, 14.5%), gingival hyperplasia (7 patients, 10.1%), hypertrichosis (6 patients, 8.7%) and sebaceous hyperplasia (9 patients, 13.1%). Adequate immunosuppression is an essential prerequisite for successful organ transplantation. In the immediate post-transplant period, significant immunosuppression is needed, but after that, the complications of excessive immunosuppression outweigh the risk of organ rejection. SORTs may present with a broad spectrum of inflammatory and cosmetic findings due to immunosuppressants that can impair life quality.
- Reasons we should not exclude the term parapsoriasis from the medical vocabulary(2021) SOUZA, Bruno de Castro e; SANCHES, Jose Antonio
- The Role of Tumor Microenvironment in the Pathogenesis of Sezary Syndrome(2022) MIYASHIRO, Denis; SOUZA, Bruno de Castro e; TORREALBA, Marina Passos; MANFRERE, Kelly Cristina Gomes; SATO, Maria Notomi; SANCHES, Jose AntonioSezary syndrome is an aggressive leukemic variant of cutaneous T-cell lymphomas, characterized by erythroderma, lymphadenopathy, and peripheral blood involvement by CD4+ malignant T-cells. The pathogenesis of Sezary syndrome is not fully understood. However, the course of the disease is strongly influenced by the tumor microenvironment, which is altered by a combination of cytokines, chemokines, and growth factors. The crosstalk between malignant and reactive cells affects the immunologic response against tumor cells causing immune dysregulation. This review focuses on the interaction of malignant Sezary cells and the tumor microenvironment.
- Case for diagnosis. Erythematous-violaceous reticulated plaques on the breasts(2022) SOUZA, Bruno de Castro e; SOUZA, Esio Pessoa Caracas de; VALENTE, Neusa Yuriko Sakai; SANCHES, Jose Antonio