LUCIANA MARAGNO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
9 resultados
Resultados de Busca
Agora exibindo 1 - 9 de 9
bookPart Dermatoses Eritematodescamativas(2018) ROMITI, Ricardo; MARAGNO, LucianabookPart O exame da pele e anexos(2021) MARAGNO, Luciana- Drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome: clinical features of 27 patients(2015) AVANCINI, J.; MARAGNO, L.; SANTI, C. G.; CRIADO, P. R.BackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) [also called drug-induced hypersensitivity syndrome (DIHS)] includes severe reactions to drugs that need to be promptly recognized by physicians. AimTo explore heterogeneity in the clinical presentation of DRESS/DIHS at a large academic hospital in Latin America, using the criteria defined by the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) scoring system. MethodsA retrospective medical record review of 60 patients with diagnostic suspicion of DRESS/DIHS admitted to our hospital between July 2008 and April 2012 was performed, including demographic data, clinical features, laboratory findings and treatment. ResultsOf the 60 patients, 27 fulfilled the criteria for DRESS/DIHS. Maculopapular exanthema (85.1%), fever (96.2%) and hepatic involvement (85.1%) were the most common features. Anticonvulsants were the most common causal drugs (77.7%); Phenytoin was the most common individual drug (44.4%), followed by carbamazepine (29.6%). All patients were treated initially with prednisone 1mg/kg/day. Mortality rate was 4%. ConclusionThe major findings of this study (to our knowledge the largest collection of data on DRESS/DIHS in Latin America) include a positive statistical association between presence of atypical lymphocytes and higher levels of alanine aminotransferase (P<0.001) and reinforce the importance of anticonvulsants in the pathogenesis of this severe reaction.
- Characterization of the humoral and insitu autoantibody profile of scalp involvement in pemphigus(2016) MARAGNO, L.; BUSSATO, W. M. M.; MARUTA, C. W.; FUKUMORI, L. M. I.; SOTTO, M. N.; SANTI, C. G.; AOKI, V.
bookPart Acne juvenil(2022) LOURENçO, Benito; MARAGNO, LucianaconferenceObject Clinical features, etiologic findings, and therapeutic response in a series of 44 patients with recurrent erythema multiforme(2012) BARBOSA, Camila Anna; SANTI, Claudia Giuli; MARAGNO, Luciana; VALENTE, Neusa Sakay; GABBI, TatianaBackground: Erythema multiforme (EM) is a mucocutaneous disorder usually self-limited but potentially recurrent. Recurrent erythema multiforme (REM) etiology is not always evident and represents a therapeutic challenge. Aim: To report clinical, etiologic, and therapeutic aspects in 44 REM patients from São Paulo, Brazil. Methods: Datawereretrospectively collected from 44 REM cases from 2000 to 2011. Results: Out of 44 patients, 29 (66%) were female, mean age at disease onset was 35.2 and average of 4.6 outbreaks per year. Forty-three patients (98%) had cutaneous lesions. Mucous membranes involvement was present in 37 patients (84%), 37 patients with oral, 19 with genital and 4 with ocular involvement. Nineteen patients out of 44 (43%) referred herpetic lesions preceding EM outbreaks, 16 were submitted to Tzanck smear and six presented a positive result for herpes simplex cytophatic effect findings. Thirty-seven patients (84%) received prednisone, 39 (88%) prophylactic acyclovir, 8 (18%) valacyclovir, and 10 (23%) dapsone. Twenty-seven of 39 patients receiving continuous acyclovir treatment had partial or complete treatment response. Recalcitrant cases were submitted to alternative treatments: 3 out of 8 patients had partial response to valacyclovir and 5 out of 9 patients had either partial or complete response to dapsone. Three patients used either thalidomide or azathioprine without enough follow-up. Conclusion: REM maintains etiologic uncertainties that lead, at times, to suboptimal therapeutic responses. The relationship between HSV and REM cannot always be proved by laboratory examination, but prophylactic therapy with acyclovir should be considered.bookPart Dermatite atópica(2022) MARAGNO, Luciana; SCARAMUZZI, Daleth RodriguesbookPart Eritema e descamação: dermatite seborreica e psoríase(2022) ARNONE, Marcelo; ROMITI, Ricardo; MARAGNO, Luciana- Extrahepatic manifestations of chronic hepatitis C infection: a consecutive study in Brazilian patients(2017) TENGAN, Fatima M.; LEVY-NETO, Mauricio; MIZIARA, Ivan D.; DANTAS, Bianca P.; MARAGNO, Luciana