LEONARDO NICOLAU GEISLER DAUD LOPES
Índice h a partir de 2011
2
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
12 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 12
bookPart Choque Cardiogênico(2016) KOPEL, Liliane; LOPES, Leonardo Nicolau Geisler Daud; BERNOCHE, Claudia Yanet San Martin- Effects of a Non-focal Plasticity Protocol on Apathy in Moderate Alzheimer's Disease: A Randomized, Double-blind, Sham-controlled Trial(2014) SUEMOTO, Claudia Kimie; APOLINARIO, Daniel; NAKAMURA-PALACIOS, Ester Miyuki; LOPES, Leonardo; LEITE, Renata Elaine Paraizo; SALES, Manuela Castro; NITRINI, Ricardo; BRUCKI, Sonia Maria; MORILLO, Lilian Shafirovitz; MAGALDI, Regina Miksian; FREGNI, FelipeBackground: Apathy is the most common neuropsychiatric symptom in Alzheimer's disease (AD) and it is associated with changes in prefrontal neural circuits involved with generation of voluntary actions. To date no effective treatment for apathy has been demonstrated. Objective: We aimed to investigate the effects and safety of repetitive transcranial direct current stimulation (tDCS) on apathy in moderate AD patients. Methods: Forty patients were randomized to receive either active or sham-tDCS over the left dorsolateral prefrontal cortex (DLPFC). Patients received six sessions of intervention during 2 weeks and were evaluated at baseline, at week 1 and 2, and after 1 week without intervention. Clinical raters, patients, and caregivers were blinded. The primary outcome was apathy. Global cognition and neuropsychiatric symptoms were examined as secondary outcomes. Results: The mean MMSE score at baseline was 15.2 +/- 2.9 and the mean Apathy Scale score was 27.7 +/- 6.7. Changes on apathy scores over time were not different between active and sham tDCS (P = 0.552 for repeated measures). Further analyses confirm that changes from baseline did not differ between groups after the sixth session (active tDCS -1.95 (95%CI -3.49, -0.41); sham-tDCS -2.05 (95% Cl -3.68, 0.42); P = 0.9891. Similarly, tDCS had no effect on secondary outcomes (P > 0.40). tDCS was well tolerated and not associated with significant adverse effects. Conclusion: In this adequately powered study for minimal clinically significant difference, our findings show that using the parameters we chose for this study, repeated anodal tDCS over the left DLPFC had no effect on apathy in elderly patients with moderate AD.
bookPart Monitorização hemodinâmica(2015) SIMOMURA, Jackson; LOPES, Leonardo Nicolau Geisler Daud; LAGE, Silvia H. G.- Aortic Counterpulsation Therapy in Patients with Advanced Heart Failure: Analysis of the TBRIDGE Registry(2016) BEZERRA, Cristiano Guedes; ADAM, Eduardo Leal; BAPTISTA, Mariana Lins; CIAMBELLI, Giuliano Serafino; KOPEL, Liliane; BERNOCHE, Claudia; LOPES, Leonardo Nicolau Geisler Daud; MACATRAO-COSTA, Milena Frota; FALCAO, Breno de Alencar Araripe; LAGE, Silvia GelasBackground: The use of aortic counterpulsation therapy in advanced heart failure is controversial. Objectives: To evaluate the hemodynamic and metabolic effects of intra-aortic balloon pump (IABP) and its impact on 30-day mortality in patients with heart failure. Methods: Historical prospective, unicentric study to evaluate all patients treated with IABP betwen August/2008 and July/2013, included in an institutional registry named TBRIDGE (The Brazilian Registry of Intra-aortic balloon pump in Decompensated heart failure - Global Evaluation). We analyzed changes in oxygen central venous saturation (ScvO(2)), arterial lactate, and use of vasoactive drugs at 48 hours after IABP insertion. The 30-day mortality was estimated by the Kaplan-Meier method and diferences in subgroups were evaluated by the Log-rank test. Results: A total of 223 patients (mean age 49 +/- 14 years) were included. Mean left ventricle ejection fraction was 24 +/- 10%, and 30% of patients had Chagas disease. Compared with pre-IABP insertion, we observed an increase in ScvO2 (50.5% vs. 65.5%, p < 0.001) and use of nitroprusside (33.6% vs. 47.5%, p < 0.001), and a decrease in lactate levels (31.4 vs. 16.7 mg/dL, p < 0.001) and use of vasopressors (36.3% vs. 25.6%, p = 0.003) after IABP insertion. Thirty-day survival was 69%, with lower mortality in Chagas disease patients compared without the disease (p = 0.008). Conclusion: After 48 hours of use, IABP promoted changes in the use of vasoactive drugs, improved tissue perfusion. Chagas etiology was associated with lower 30-day mortality. Aortic counterpulsation therapy is an effective method of circulatory support for patients waiting for heart transplantation.
bookPart Choque cardiogênico(2016) KNOBEL, Elias; LOPES, Leonardo Nicolau Geisler Daud; RHODES, AndrewconferenceObject Intra-aortic balloon pump as a bridge therapy to heart transplant in refractory heart failure(2020) BOROS, G. A. B.; BELLINI, V. S. C.; FATORI, D.; BERNOCHE, C.; MACATRAO-COSTA, M. F.; LOPES, L. N. G. D.; BACAL, F.; HUEB, W.; KOPEL, L.; LAGE, S. G.- I Diretriz de ressuscitação cardiopulmonar e cuidados cardiovasculares de emergência da Sociedade Brasileira de Cardiologia(2013) GONZALEZ, M. M.; TIMERMAN, S.; GIANOTTO-OLIVEIRA, R.; POLASTRI, T. F.; CANESIN, M. F.; SCHIMIDT, A.; SIQUEIRA, A. W.; PISPICO, A.; LONGO, A.; PIERI, A.; REIS, A.; TANAKA, A. C. S.; SANTOS, A. M.; QUILICI, A. P.; RIBEIRO, A. C. L.; BARRETO, A. C. P.; PAZIN-FILHO, A.; TIMERMAN, A.; MACHADO, C. A.; FRANCHIN NETO, C.; MIRANDA, C. H.; MEDEIROS, C. R.; MALAQUE, C. M. S.; BERNOCHE, C.; GONCALVES, D. M.; SANT'ANA, D. G.; OSAWA, E. A.; PEIXOTO, E.; ARFELLI, E.; EVARISTO, E. F.; AZEKA, E.; GOMES, E. P.; WEN, F. H.; FERREIRA, F. G.; LIMA, F. G.; MATTOS, F. R.; GALAS, F. G.; MARQUES, F. R. B.; TARASOUTCHI, F.; MANCUSO, F. J. N.; FREITAS, G. R.; FEITOSA-FILHO, G. S.; BARBOSA, G. C.; GIOVANINI, G. R.; MIOTTO, H. C.; GUIMARAES, H. P.; ANDRADE, J. P.; OLIVEIRA-FILHO, J.; FERNANDES, J. G.; MORAES JUNIOR, J. B. M. X.; CARVALHO, J. J. F.; RAMIRES, J. A. F.; CAVALINI, J. F.; TELES, J. M. M.; LOPES, J. L.; LOPES, L. N. G. D.; PIEGAS, L. S.; HAJJAR, L. A.; BRUNORIO, L.; DALLAN, L. A. P.; CARDOSO, L. F.; RABELO, M. M. N.; ALMEIDA, M. F. B.; SOUZA, M. F. S.; FAVARATO, M. H.; PAVAO, M. L. R. C.; SHIMODA, M. S.; OLIVEIRA JUNIOR, M. T.; MIURA, N.; FILGUEIRAS FILHO, N. M.; PONTES-NETO, O. M.; PINHEIRO, P. A. P. C.; FARSKY, O. S.; LOPES, R. D.; SILVA, R. C. G.; KALIL FILHO, R.; GONCALVES, R. M.; GAGLIARDI, R. J.; GUINSBURG, R.; LISAK, S.; ARAUJO, S.; MARTINS, S. C. O.; LAGE, S. G.; FRANCHI, S. M.; SHIMODA, T.; ACCORSI, T. D.; BARRAL, T. C. N.; MACHADO, T. A. O.; SCUDELER, T. L.; LIMA, V. C.; GUIMARAES, V. A.; SALLAI, V. S.; XAVIER, W. S.; NAZIMA, W.; SAKO, Y. K.
bookPart Drogas vasoativas(2016) ABUD, Isabela Cristina Kirnew; LOPES, Leonardo Nicolau Geisler Daud; LAGE, Silvia H. G.bookPart Monitorização hemodinâmica(2016) GONçALVES, Carolina Santana dos Reis; LOPES, Leonardo Nicolau Geisler Daud; LAGE, Silvia H. G.bookPart Monitorização hemodinâmica(2018) SIMOMURA, Jackson; MACATRãO-COSTA, Milena Frota; LOPES, Leonardo Nicolau Geisler Daud; LAGE, Silvia H. G.