NATHALIA COELHO PORTILHO KELMANN
Projetos de Pesquisa
Unidades Organizacionais
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
bookPart Testes alérgicos in vivo(2021) MOTTA, Antonio Abílio; KELMANN, Nathália Coelho Portilho; GRECCO, OctaviobookPart Anafilaxia perioperatória(2021) D'ONOFRIO-SILVA, Ana Carolina; KELMANN, Nathália Coelho Portilho- Severe Cutaneous Adverse Reactions to Drugs in Latin America: The RACGRAD Study(2021) V, D. Rojas Mejia; ZWIENER, R. D.; VILLA, R. Cardona; RAMIREZ, L. F.; ESPINOSA, D. L. Silva; ZANACCHI, V. A.; SOSA, P. Piraino; ENSINA, L. F.; BIANCHI, P. Giavina; PORTILHO, N. Coelho; AUN, M. Vivolo; BENAVIDES, E. Matos; RUIZ, D. M. Martinez; JARES, E.; REYES, C. D. SerranoBackground: Severe cutaneous adverse reactions to drugs (SCARs) are associated with high morbidity and mortality and with sequelae. Objective: To characterize patients with SCARs in 8 health care institutions in Latin America. Methods: We performed a cross-sectional, descriptive, multicenter study of patients diagnosed with SCARs in Latin America between January 2009 and December 2018. The analysis was carried out using a database in BD Clinic. Results: We collected 70 patients, of whom 42 (60%) were women. Mean age was 38.7 years. Forty-two patients (60%) had DRESS-DIHS, 12 (17.1%) TEN, 5 (7.1%) SJS, 6 (8.5%) AGEP, 4 (5.7%) other reactions not classified as SCARs, and 1 (1.4%) overlapping SJS-TEN. The main causative drugs were aromatic anticonvulsants in 31 cases (44.3%), beta-lactam antibiotics in 11 cases (15.7%), and non-beta-lactam antibiotics in 6 cases (8.6%). In all of the cases, the suspected drug was withdrawn at the first sign of a SCAR. Sixty-six patients (94.2%) received anti-inflammatory treatment, mostly systemic corticosteroids. Complications occurred in 53 cases (75.7%), and 3 patients died (4.3%). Thirteen patients (18.6%) had sequelae. Conclusions: This is the first multicenter report on SCARs in Latin America. DRESS-DIHS was the most frequently reported clinical entity, and anticonvulsants were the main triggers. Most of the patients received systemic corticosteroids. Complications were frequent, and 3 patients died.
bookPart Anti-inflamatórios não esteroidais(2022) AUN, Marcelo Vivolo; HOFF, Manoela Crespo de Magalhães; KELLMAN, Nathália Coelho Portilho; GIAVINA-BIANCHI, Pedro- Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction(2020) PEREIRA, Amanda Rocha Firmino; AUN, Marcelo Vivolo; KELMANN, Nathalia Coelho Portilho; MOTTA, Antonio Abilio; KALIL, Jorge; GIAVINA-BIANCHI, PedroThe fixed drug eruption is a non-immediate hypersensitivity reaction to drug, characterized by recurrent erythematous or violaceous, rounded, well-defined border plaques, which always appear in the same location every time the culprit drug is administered. The usual practice is to avoid the drug involved and to use a structurally different drug. However, there are situations in which there is no safe and effective therapy. In such situations, desensitization is the only option. We describe the case of a patient who presented fixed eruption due to sulfamethoxazole-trimethoprim, who underwent successful desensitization, but required a repeat procedure twice due to relapse after inadvertent full-dose reintroduction. In non-immediate hypersensitivity reaction to drug, the indication is controversial and there is no technical standardization. Furthermore, the time at which such tolerance is lost after discontinuing the drug involved is unknown. In severe non-immediate reactions of types II and III, desensitization is contraindicated. The patient underwent desensitisation to sulfamethoxazole-trimethoprim three times - the first with recurrence of lesions and the second and third without manifestations, all concluded successfully and with no premedication.
conferenceObject Hereditary angioedema with normal C1 inhibitor: prevalence, clinical features and treatment of patients in a University Hospital in Brazil(2015) V, M. Arun; LONGEN, E.; PORTILHO, N. C.; AGONDI, R. C.; KALIL, J.; MOTTA, A. A.; GIAVINA-BIANCHI, P.bookPart Testes Alérgicos in vivo(2015) RIBEIRO, Marisa Rosimeire; COELHO, Nathalia PortilhobookPart Antibióticos(2022) AUN, Marcelo Vivolo; KELLMAN, Nathália Coelho Portilho