MARCELLA SOARES PINCELLI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
15 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 15
bookPart Vegetação(2019) PINCELLI, Marcella- Cutaneous metastases from solid neoplasms - Literature review(2023) SOUZA, Bruno de Castro e; MIYASHIRO, Denis; PINCELLI, Marcella Soares; SANCHES, Jose AntonioCutaneous metastases from solid tumors are uncommon events in clinical practice. Most of the time, the patient already has the diagnosis of a malignant neoplasm when the cutaneous metastasis is detected. However, in up to one-third of cases, cutaneous metastasis is identified before the primary tumor. Therefore, its identification may be essential for starting treatment, although it is usually indicative of poor prognosis. The diagnosis will depend on clinical, histopathological, and immunohistochemical analysis. Sometimes the identification of the primary site is difficult; however, a thorough analysis using imaging tests and constant surveillance is important. (c) 2023 Sociedade Brasileira de Dermatologia.
bookPart Farmacodermias(2022) GUIMARãES, Ana Lúcia Monteiro; PINCELLI, Marcella Soares; NICO, Marcello Menta Simonsen- Livedo Racemosa: Clinical, Laboratory, and Histopathological Findings in 33 Patients(2021) PINCELLI, Marcella Soares; ECHAVARRIA, Alejandra Maria Jimenez; CRIADO, Paulo Ricardo; MARQUES, Gabriela Franco; MORITA, Thamara Cristiane Alves Batista; VALENTE, Neusa Yuriko Sakai; CARVALHO, Joselio Freire deLivedo racemosa is a cutaneous finding characterized by a persistent, erythematous, or violaceous discoloration of the skin, in a broken, branched, discontinuous, and irregular pattern. A retrospective review of 33 cases with clinical diagnosis of livedo racemosa over the past 6 years was evaluated in the dermatology department of a tertiary care hospital. We found predominance in Caucasian women (78.8%); age ranged from 8 to 81 years, with a mean age of 36 years. Livedo racemosa was described as generalized in 12 patients (36.4%), although the main localization was on lower limbs (42%). After laboratory testing and histopathological examinations, 12 patients (36.4%) were classified with idiopathic livedo racemosa; secondary diseases were diagnosis in 21 patients (63.6%), including Sneddon's syndrome, cutaneous polyarteritis nodosa, systemic lupus erythematosus, and others. Medical history of thrombotic events was described in 8 (24.2%) patients, and also 8 (24.2%) patients had abnormal results for 2 or more thrombophilia laboratory tests. Skin biopsy showed no histological abnormalities in 11 cases (33.3%), thrombosis of dermal blood vessels in 10 (30.3%), intimal/subintimal thickening in 7 (21.2%), and vasculitis in 5 (15.2%). In conclusion, livedo racemosa is a clinical feature that might be correlated to vascular disorders, such as thrombotic and/or hypercoagulable states, autoimmune diseases, and neoplastic diseases, or it can be secondary to specific medications. It is essential to establish a correct approach in cases of livedo racemosa, which includes anamnesis, physical examination, laboratory test, histological examination, and complementary examination according to clinical findings, in order to diagnosis underlying causes.
- Modeling pulmonary fibrosis by abnormal expression of telomerase/apoptosis/collagen V in experimental usual interstitial pneumonia(2014) PARRA, E. R.; PINCELLI, M. S.; TEODORO, W. R.; VELOSA, A. P. P.; MARTINS, V.; RANGEL, M. P.; BARBAS-FILHO, J. V.; CAPELOZZI, V. L.Limitations on tissue proliferation capacity determined by telomerase/apoptosis balance have been implicated in pathogenesis of idiopathic pulmonary fibrosis. In addition, collagen V shows promise as an inductor of apoptosis. We evaluated the quantitative relationship between the telomerase/apoptosis index, collagen V synthesis, and epithelial/fibroblast replication in mice exposed to butylated hydroxytoluene (BHT) at high oxygen concentration. Two groups of mice were analyzed: 20 mice received BHT, and 10 control mice received corn oil. Telomerase expression, apoptosis, collagen I, III, and V fibers, and hydroxyproline were evaluated by immunohistochemistry, in situ detection of apoptosis, electron microscopy, immunofluorescence, and histomorphometry. Electron microscopy confirmed the presence of increased alveolar epithelial cells type 1 (AEC1) in apoptosis. Immunostaining showed increased nuclear expression of telomerase in AEC type 2 (AEC2) between normal and chronic scarring areas of usual interstitial pneumonia (UIP). Control lungs and normal areas from UIP lungs showed weak green birefringence of type I and III collagens in the alveolar wall and type V collagen in the basement membrane of alveolar capillaries. The increase in collagen V was greater than collagens I and III in scarring areas of UIP. A significant direct association was found between collagen V and AEC2 apoptosis. We concluded that telomerase, collagen V fiber density, and apoptosis evaluation in experimental UIP offers the potential to control reepithelization of alveolar septa and fibroblast proliferation. Strategies aimed at preventing high rates of collagen V synthesis, or local responses to high rates of cell apoptosis, may have a significant impact in pulmonary fibrosis.
- Extensive scalp ulcer secondary to delusional infestation treated with antipsychotics and scalp reconstruction(2020) PINCELLI, M. S.; GUIMARARES, A. L. M.; MILCHESKI, D. A.; DWAN, A. J.; NICO, M. M. S.
- Evaluation of a diagnostic algorithm for mastocytosis in skin biopsies and CD25 expression in skin mast cells of 49 patients followed up at a Tertiary Hospital in Sao Paulo, Brazil(2024) VIEIRA, Marina L.; SAMORANO, Luciana P.; PINCELLI, Marcella S.; RIVITTI-MACHADO, Maria C. da M.; OLIVEIRA, Zilda N. P. de
bookPart Dermatoses agudas(2022) PINCELLI, Marcella Soares; GUIMARãES, Ana Lúcia Monteiro; NICO, Marcello Menta SimonsenbookPart Dermatoses agudas(2021) PINCELLI, Marcella Soares; GUIMARãES, Ana Lúcia Monteiro; NICO, Marcello Menta SimonsenbookPart Vitiligo vulvar na infância e na adolescência(2021) SANTI, Claudia Giuli; PINCELLI, Marcella Soares