ROSSANA VERONICA MENDOZA LOPEZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
87 resultados
Resultados de Busca
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- Host feeding patterns of Nyssorhynchus darlingi (Diptera: Culicidae) in the Brazilian Amazon(2021) NAGAKI, Sandra Sayuri; CHAVES, Leonardo S. M.; LOPEZ, Rossana Veonica Mendoza; BERGO, Eduardo S.; LAPORTA, Gabriel Z.; CONN, Jan E.; SALLUM, Maria Anice MurebNyssorhynchus darlingi (Root) is the dominant malaria vector in the Brazilian Amazon River basin, with additional Anophelinae Grassi species involved in local and regional transmission. Mosquito blood-feeding behavior is an essential component to define the mosquito-human contact rate and shape the transmission cycle of vector-borne diseases. However, there is little information on the host preferences and blood-feeding behavior of Anophelinae vectors in rural Amazonian landscapes. The barrier screen sampling (BSS) method was employed to sample females from 34 peridomestic habitats in 27 rural communities from 11 municipalities in the Brazilian Amazon states of Acre, Amazonas, Par ' a and Rondonia, from August 2015 to November 2017. Nyssorhynchus darlingi comprised 97.94% of the females collected resting on barrier screens, and DNA sequence comparison detected 9 vertebrate hosts species. The HBI index ranged from 0.03-1.00. Results revealed the plasticity of Ny. darlingi in blood-feeding on a wide range of mainly mammalian hosts. In addition, the identification of blood meal sources using silica-dried females is appropriate for studies of human malaria vectors in remote locations.
conferenceObject UTILIZATION OF PROPENSITY SCORE IN COMPARISON OF TWO THERAPEUTIC OPTIONS IN PATIENTS WITH SQUAMOUS CELL CARCINOMA OF HEAD AND NECK, BRAZIL 1998-2008(2015) CAMPOLINA, A. G.; COSTA, A.; V, R. Lopez- Tolerability of modified gemcitabine/docetaxel (split-dose) in patients with advanced soft tissue sarcomas(2016) AZEVEDO, R. G. M. V. D.; FRAILE, N.; SAADI NETO, E.; LOPEZ, R. V. M.; TOLOI, D.; HOFF, P. M.; FEHER, O.; CAMARGO, V. P. D.; MUNHOZ, R.
- Return to work after breast cancer diagnosis: An observational prospective study in Brazil(2018) LANDEIRO, Luciana C. G.; GAGLIATO, Debora M.; FEDE, Angelo B.; FRAILE, Natalia M.; LOPEZ, Rossana M.; FONSECA, Leonardo G. da; PETRY, Vanessa; TESTA, Laura; HOFF, Paulo M.; MANO, Max S.Background In North America and Europe, return-to-work (RTW) rates vary among breast cancer (BC) survivors, from 24% to 66% and from 53% to 82% at 6 and 36 months after diagnosis, respectively. To date, there is a lack of data on RTW rates after BC diagnosis in Latin America. Therefore, the primary objectives of this study were to define RTW rates at 12 and 24 months after BC diagnosis and to identify the factors associated with RTW in this population. Methods In total, 125 employed women from a single institution with newly diagnosed BC were interviewed by telephone at 6, 12, and 24 months after diagnosis. Those who had inoperable or metastatic disease were excluded. Results Overall, RTW rates were 30.3% and 60.4% at 12 and 24 months after BC diagnosis, respectively. Most women reported that they received support from their employer, but only 29.1% reported having been offered work adjustments. In multivariate analysis, the factors associated with positive RTW outcomes included higher household income (odds ratio [OR], 17.76; 95% confidence interval [CI], 3.33-94.75; P = .001), breast-conserving surgery (OR, 9.77; 95% CI, 2.03-47.05; P = .004), and work adjustments (OR, 37.62; 95% CI, 2.03-47.05; P = .004). The factors associated with negative RTW outcomes included adjuvant endocrine therapy (OR, 0.11; 95% CI, 0.02-0.74; P = .023), and depression diagnosed after BC (OR, 0.07; 95% CI, 0.01-0.63; P = .017). Conclusions RTW rates in the current study were lower than those observed in developed countries but similar to the rates among low-income Americans. Workplace adjustments, higher income, breast-conserving surgery, endocrine therapy, and depression after BC played an important role in the RTW decision. Cancer 2018;124:4700-4710. (C) 2018 American Cancer Society.
- Co-infection of sexually transmitted pathogens and Human Papillomavirus in cervical samples of women of Brazil(2017) AMORIM, Aline Teixeira; MARQUES, Lucas Miranda; CAMPOS, Guilherme Barreto; LOBAO, Tassia Neves; LINO, Vanesca de Souza; CINTRA, Ricardo Cesar; ANDREOLI, Maria Antonieta; VILLA, Luisa Lina; BOCCARDO, Enrique; BRAGA JUNIOR, Antonio Carlos Ricardo; LOPEZ, Rossana Veronica Mendoza; SANTOS, Djanilson Barbosa dos; SOUZA, Gerson Maciel de; ROMANO, Carla Cristina; TIMENETSKY, JorgeBackground: Some sexually transmitted infectious agents, such as Chlamydia trachomatis and Herpes simplex, cause local inflammation, and could contribute to Human Papillomavirus (HPV) and cervical lesion progression. Thus, the aim of this study was to determine any association between the presence of microorganisms of gynecological importance, sexual behavior, clinical and demographical variables to the development and progress of cervical lesions. Methods: One hundred and thirty-two women between 14 and 78 years and living at Vitoria da Conquista, Bahia, Brazil, were included (62 individuals with cervical lesions and 70 without lesions). They answered a questionnaire to provide data for a socioeconomic and sexual activity profile. Samples of cervical swabs were collected and analyzed by PCR to detect genital microorganisms and HPV. Quantitative PCR was used to detect and quantify Ureaplasma urealyticum and Ureaplasma parvum. Univariate and multiple logistic regression were performed to measure the association with the cervical lesions, and an odds ratio (OR) with 95% confidence intervals (95% CI) were calculated. The Mann-Whitney U test was also used to compare the microorganism load in the case and control groups. The significance level was 5% in all hypotheses tested. Results: Cervical lesions were associated with: women in a stable sexual relationship (OR = 14.21, 95% CI = 3.67-55.018), positive PCR for HPV (OR = 16.81, 95% CI = 4.19-67.42), Trichomonas vaginalis (OR = 8.566, 95% CI = 2.04-35.94) and Gardnerella vaginalis (OR = 6.13, 95% CI = 1.53-24.61), adjusted by age and qPCR for U. parvum. U. parvum load showed a statistical difference between the case and control groups (p-value = 0.002). Conclusion: Variables such as stable relationship, HPV, T. vaginalis, G. vaginalis were associated with cervical lesions in epidemiological studies. U. parvum load was higher in woman with cervical lesions compared with women without lesions. Additional studies are needed to better understand the role of these factors in cervical lesion development.
- Palliative cancer care: costs in a Brazilian quaternary hospital(2022) ROZMAN, Luciana Martins; CAMPOLINA, Alessandro Goncalves; LOPEZ, Rossana Mendoza; CHIBA, Toshio; SOAREZ, Patricia Coelho DePalliative care (PC) improves the quality of life of patients with diseases such as cancer, and several studies have shown a reduction in costs among patients who use PC services when compared with those receiving standard oncological treatments. Most studies on PC costs are carried out in high-income countries. There is a lack of these types of studies in middle-income and low-income countries and of better evidence about this intervention. Objective To describe resource utilisation and costs among patients with cancer in a Brazilian quaternary hospital by cancer localisation and per month of treatment before death. Methods This study is a description of retrospective costs to estimate the costs of formal healthcare sector associated with PCs, from the perspective of a public quaternary cancer hospital. Unit costs were estimated using microcosting and macrocosting approaches. Setting/Participants Patients older than 18 years old who died from 2010 to 2013 and who had at least two visits in PC and/or made use of hospice care. Results Among the 2985 patients included in the study, the average cost per patient was US$12 335, ranging from US$8269 for patients with pancreatic cancer to US$19 395 for patients with brain cancer. The main costing item was hospital admission (47.6% of the total cost), followed by hospice care (29.5%) and medical and other supplies (11.1%). Conclusions The study clarified the direct medical costs and the profile and use of resources of patients with cancer who need PC, and can help in the planning and allocation of resources in cancer care.
- Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction(2023) POLACHINI, Giovana Mussi; CASTRO, Tialfi Bergamin de; SMARRA, Luis Fabiano Soares; HENRIQUE, Tiago; PAULA, Carlos Henrique Diniz de; SEVERINO, Patricia; LOPEZ, Rossana Veronica Mendoza; CARVALHO, Andre Lopes; ZERI, Ana Carolina de Mattos; SILVA, Ismael Dale Cotrim Guerreiro; TAJARA, Eloiza H.Metabolomics has proven to be an important omics approach to understand the molecular pathways underlying the tumour phenotype and to identify new clinically useful markers. The literature on cancer has illustrated the potential of this approach as a diagnostic and prognostic tool. The present study aimed to analyse the plasma metabolic profile of patients with oral squamous cell carcinoma (OSCC) and controls and to compare patients with metastatic and primary tumours at different stages and subsites using nuclear magnetic resonance and mass spectrometry. To our knowledge, this is the only report that compared patients at different stages and subsites and replicates collected in diverse institutions at different times using these methodologies. Our results showed a plasma metabolic OSCC profile suggestive of abnormal ketogenesis, lipogenesis and energy metabolism, which is already present in early phases but is more evident in advanced stages of the disease. Reduced levels of several metabolites were also associated with an unfavorable prognosis. The observed metabolomic alterations may contribute to inflammation, immune response inhibition and tumour growth, and may be explained by four nonexclusive views-differential synthesis, uptake, release, and degradation of metabolites. The interpretation that assimilates these views is the cross talk between neoplastic and normal cells in the tumour microenvironment or in more distant anatomical sites, connected by biofluids, signalling molecules and vesicles. Additional population samples to evaluate the details of these molecular processes may lead to the discovery of new biomarkers and novel strategies for OSCC prevention and treatment.
- Lipid profile as a new diagnostic marker in head and neck cancer(2022) CASTRO, T. B. D.; POLACHINI, G. M.; SMARRA, L. F. S.; HENRIQUE, T.; LOPEZ, R. V. M.; ZERI, A. C. D. M.; SILVA, I. D. C. G. D.; VANDENBOSCH, M.; HEEREN, R. M.; SILVA, E. H. Tajara da
- GTSP1 expression in non-smoker and nondrinker patients with squamous cell carcinoma of the head and neck(2017) SOARES, Pamela de Oliveira; CURY, Patricia Maluf; LOPEZ, Rossana Veronica Mendoza; CERNEA, Claudio Roberto; FUKUYAMA, Erika Erina; FIGUEIREDO, David Livingstone Alves; NOBREGA, Francisco Gorgonio da; CURIONI, Otavio Alberto; NUNES, Fabio Daumas; MOYSES, Raquel Ajub; GARCIA, Maria Lucia BuenoIntroduction The main risk factors for head and neck squamous cell carcinoma (HNSCC) are tobacco and alcohol consumption and human papillomavirus (HPV) infection. However, in a subset of patients, no risk factors can be identified. Glutathione S-transferase p (GTSP1) is a carcinogen-detoxifying enzyme that is activated by exposure to carcinogens, and it is associated with a reduction in response to toxic therapies. We studied the expression of GTSP1 in tumor and non-tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens. Materials and methods Non-smoker/non-drinker (NSND) and smoker/drinker (SD) patients were matched according to age, gender, tumor site, TNM stage, grade and histological variants to establish 47 pairs of patients who have been previously tested for HPV. GTSP1 immunostaining was analyzed using a semi-quantitative method with scores ranging from 0 to 3 according to the area of immunostaining. Results GTSP1 expression was detected in the tumors of both groups. GTSP1 expression was higher in the non-tumor margins of SD patients (p = 0.004). There was no association between GTSP1 expression and positivity for HPV. No differences in survival were observed according to GTSP1 staining in tumors and non-tumor margins. Conclusion This study showed that GTSP1 was expressed in tumors of HNSCC patients regardless of smoking, drinking or HPV infection status. The difference in GTSP1 expression in non-tumor margins between the two groups may have been due to two possible reasons. First, elevated GTSP1 expression in SD patients might be the result of activation of GTSP1 in response to exposure to carcinogens. Second, alternatively, impairment in the detoxifying system of GTSP1, as observed by the reduced expression of GTSP1, might make patients susceptible to carcinogens other than tobacco and alcohol, which may be the underlying mechanism of carcinogenesis in the absence of risk factors.
- Abundance of impacted forest patches less than 5 km(2) is a key driver of the incidence of malaria in Amazonian Brazil(2018) CHAVES, Leonardo Suveges Moreira; CONN, Jan E.; LOPEZ, Rossana Veronica Mendoza; SALLUM, Maria Anice MurebThe precise role that deforestation for agricultural settlements and commercial forest products plays in promoting or inhibiting malaria incidence in Amazonian Brazil is controversial. Using publically available databases, we analyzed temporal malaria incidence (2009-2015) in municipalities of nine Amazonian states in relation to ecologically defined variables: (i) deforestation (rate of forest clearing over time); (ii) degraded forest (degree of human disturbance and openness of forest canopy for logging) and (iii) impacted forest (sum of deforested and degraded forest patches). We found that areas affected by one kilometer square of deforestation produced 27 new malaria cases (r(2) = 0.78; F1,10 = 35.81; P < 0.001). Unexpectedly, we found both a highly significant positive correlation between number of impacted forest patches less than 5 km(2) and malaria cases, and that these patch sizes accounted for greater than similar to 95% of all patches in the study area. There was a significantly negative correlation between extraction forestry economic indices and malaria cases. Our results emphasize not only that deforestation promotes malaria incidence, but also that it directly or indirectly results in a low Human Development Index, and favors environmental conditions that promote malaria vector proliferation.