LIDIA YURI MIMURA

Índice h a partir de 2011
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Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico

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  • article 7 Citação(ões) na Scopus
    Treatment of mild to moderate Graves' ophthalmopathy with sodium diclofenac: a pilot study
    (2011) BLOISE, Walter; MIMURA, Lidia Yuri; MOURA, Janete; NICOLAU, Wilian
    Objective: To report the use of sodium diclofenac, an antagonist of PPAR-gamma and cyclooxigenase-2 (COX-2) inhibitor in the treatment of mild to moderate Graves' ophthalmopathy. Subjects and methods: Thirteen patients with clinical activity score (CAS) 2 to 7 were treated during a period ranging from 3 to 12 months (mean 7.8 +/- 3.4) with oral sodium diclofenac, 50 mg every 12 hours. Results: Extra-ocular muscle restriction and CAS improved significantly, p = 0.003 and = 0.004, respectively. Ocular pain and diplopia disappeared, except for one patient who reported improvement of these symptoms. No recurrence was found after interruption of treatment. Conclusions: Treatment of moderate Graves' ophthalmopathy with oral sodium diclofenac is a good, safe and less expensive therapeutic option. Like others new treatment trials, findings must be confirmed in a greater number of patients in a controlled study. Arq Bras Endocrinol Metab. 2011;55(9):692-5