CARLOS JOSE DORNAS GONCALVES BARBOSA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
17 resultados
Resultados de Busca
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conferenceObject Is there a Correlation Between Bleeding Risk Score and Platelet Aggregability?(2014) ARANTES, Flavia B.; FURTADO, Remo H.; BARBOSA, Carlos J.; FRANCI, Andre; MENEZES, Fernando R.; FALCAO, Talia D.; NAKASHIMA, Carlos A.; BARACIOLI, Luciano M.; RAMIRES, Jose A.; NICOLAU, Jose C.- Do Diabetic Patients with Acute Coronary Syndromes Have a Higher Threshold for Ischemic Pain?(2014) NICOLAU, Jose Carlos; BARBOSA, Carlos Jose Dornas Goncalves; FRANCI, Andre; BARACIOLI, Luciano Moreira; FRANKEN, Marcelo; LIMA, Felipe Gallego; GIRALDEZ, Roberto Rocha; KALIL FILHO, Roberto; RAMIRES, Jose Antonio Franchini; GIUGLIANO, Robert P.Background: Data from over 4 decades have reported a higher incidence of silent infarction among patients with diabetes mellitus (DM), but recent publications have shown conflicting results regarding the correlation between DM and presence of pain in patients with acute coronary syndromes (ACS). Objective: Our primary objective was to analyze the association between DM and precordial pain at hospital arrival. Secondary analyses evaluated the association between hyperglycemia and precordial pain at presentation, and the subgroup of patients presenting within 6 hours of symptom onset. Methods: We analyzed a prospectively designed registry of 3,544 patients with ACS admitted to a Coronary Care Unit of a tertiary hospital. We developed multivariable models to adjust for potential confounders. Results: Patients with precordial pain were less likely to have DM (30.3%) than those without pain (34.0%; unadjusted p = 0.029), but this difference was not significant after multivariable adjustment, for the global population (p = 0.84), and for subset of patients that presented within 6 hours from symptom onset (p = 0.51). In contrast, precordial pain was more likely among patients with hyperglycemia (41.2% vs 37.0% without hyperglycemia, p = 0.035) in the overall population and also among those who presented within 6 hours (41.6% vs. 32.3%, p = 0.001). Adjusted models showed an independent association between hyperglycemia and pain at presentation, especially among patients who presented within 6 hours (OR = 1.41, p = 0.008). Conclusion: In this non-selected ACS population, there was no correlation between DM and hospital presentation without precordial pain. Moreover, hyperglycemia correlated significantly with pain at presentation, especially in the population that arrived within 6 hours from symptom onset.
conferenceObject ACUTE CORONARY SYNDROMES IN THE VERY OLD: THERAPIES AND OUTCOME IN THE LONG-TERM FOLLOW-UP(2014) NICOLAU, Jose C.; FRANCI, Andre; BARBOSA, Carlos; BARACIOLI, Luciano; FURTADO, Remo; GIANNETTI, Natali; GIRALDEZ, Roberto; LIMA, Felipe; FRANKEN, Marcelo; RAMIRES, Jose; KALIL-FILHO, Roberto; FERRAZ, ThiagoconferenceObject INCREASED BODYWEIGHT AND INADEQUATE RESPONSE TO ASPIRIN IN INDIVIDUALS WITH CORONARY ARTERY DISEASE(2019) FURTADO, Remo Holanda de Mendonca; ARANTES, Flavia; BARBOSA, Carlos; FRANCI, Andre; MENEZES, Fernando; SALSOSO, Rocio; DALCOQUIO, Talia; NAKASHIMA, Carlos; SCANAVINI FILHO, Marco; FERRARI, Aline; GENESTRETI, Paulo; BARACIOLI, Luciano; NICOLAU, Jose C.- Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST (II Edição, 2007) - Atualização 2013/2014(2014) NICOLAU, JC; TIMERMAN, A; MARIN-NETO, JA; PIEGAS, LS; BARBOSA, CJDG; FRANCI, A; AVEZUM JR., A; CARVALHO, ACC; MARKMAN FILHO, B; POLANCZYK, CA; ROCHITTE, CE; SERRANO JÚNIOR, CV; PRECOMA, DB; SILVA JUNIOR, DG; ALBUQUERQUE, DC; STEFANINI, E; KNOBEL, E; JATENE, FB; FERES, F; MORCERF, FAP; GANEM, F; LIMA FILHO, FA; FEITOSA FILHO, GS; FERREIRA, JFM; MENEGHETTI, JC; SARAIVA, JFK; SILVA, LS; MAIA, LN; BARACIOLI, LM; LISBOA, LAF; DALLAN, LAO; BODANESE, LC; ANDRADE, MD; OLIVEIRA JÚNIOR, M; DUTRA, OP; COELHO, OR; LEÃES, PE; ALBUQUERQUE, PF; LEMOS, P; KALIL, R; COSTA, RVC; ESPORCATE, R; MARINO, RL; BOTELLHO, RV; MENEGHELO, RS; SPROVIERI, SR; TIMERMAN, S; MATHIAS JÚNIOR, W
conferenceObject Mortality impact of previous coronary angioplasty in the long-term follow-up of patients with acute coronary syndromes submitted to coronary artery bypass surgery during the same hospitalization(2014) NICOLAU, J. C.; FRANKEN, M.; FERRAZ, T.; FRANCI, A.; BARBOSA, C. J. D. G.; KALIL FILHO, R.; RAMIRES, J. A. F.; LISBOA, L. A. F.; DALLAN, L. A. O.; JATENE, F. B.- Lipid transfer to high-density lipoproteins in coronary artery disease patients with and without previous cerebrovascular ischemic events(2019) BARBOSA, Carlos J. D. G.; MARANHAO, Raul C.; BARREIROS, Renata S.; FREITAS, Fatima R.; FRANCI, Andre; STRUNZ, Celia M. C.; ARANTES, Flavia B. B.; TAVONI, Thauany M.; RAMIRES, Jose A. F.; KALIL FILHO, Roberto; NICOLAU, Jose C.Background Patients with coronary artery disease (CAD) and previous ischemic cerebrovascular events (ICVE, ischemic stroke, or transitory ischemic attack) constitute a high-risk subgroup for cardiovascular outcomes. High-density lipoprotein cholesterol (HDL-C) levels are correlated with cardiovascular events. Lipid transfer to HDL affects structure size and HDL subclass profile. Impairment of this transfer could influence ischemic risk seen in patients with CAD + ICVE. The objective was to evaluate the HDL ability to receive the lipids in patients with CAD with or without ICVE. Methods Patients with CAD + ICVE (n = 60) and patients with CAD only (n = 60) were matched by age, sex, acute coronary syndromes (ACS) event type, and time elapsed between the ACS event and inclusion in the study. Lipid transfer to HDL was evaluated by incubating donor lipid nanoparticles labeled with radioactive unesterified cholesterol (UC) and esterified cholesterol (EC), phospholipid (PL), and triglyceride (TG) with whole plasma. After the chemical precipitation of non-HDL fractions and nanoparticles, the supernatant was counted for HDL radioactivity. Results CAD + ICVE group presented with impaired lipid transfer to HDL for PL (CAD + ICVE: 21.14 +/- 2.7% vs CAD: 21.67 +/- 3.1%, P = .03), TG (CAD + ICVE: 4.88 +/- 0.97% vs CAD: 5.63 +/- 0.92%, P = .002), and UC (CAD + ICVE: 5.55 +/- 1.19% vs CAD: 6.16 +/- 1.14%, P = .009). Lipid transfer to HDL was similar in both groups for EC. Adjusted models showed similar results. Conclusion Patients with CAD and ICVE have reduced lipid transfer to HDL compared to those with CAD only. Dysfunctional HDL may account for the higher incidence of ischemic outcomes observed in this population.
conferenceObject DRUG INTERACTION BETWEEN CLOPIDOGREL AND RANITIDINE OR OMEPRAZOLE IN PATIENTS WITH CORONARY HEART DISEASE: A DOUBLE-BLIND, DOUBLE-DUMMY, RANDOMIZED COMPARATIVE STUDY(2014) FURTADO, Remo Holanda de Mendonca; FREIRE, Beatriz Tonon; STRUNZ, Celia; BARBOSA, Carlos J. D. G.; FRANCI, Andre; ARANTES, Flavia B. B.; FILHO, Cyrillo C.; MENEZES, Fernando R.; D'AMICO, Elbio A.; NICOLAU, Jose- Influence of proven oral therapies in the very old with acute coronary syndromes: A 15 year experience(2015) NICOLAU, Jose C.; FRANCI, Andre; BARBOSA, Carlos Jose D. G.; BARACIOLI, Luciano M.; FRANKEN, Marcelo; FURTADO, Remo H. M.; GIRALDEZ, Roberto R. C. V.; GANEM, Fernando; LIMA, Felipe G.; MENEZES, Fernando R.; ARANTES, Flavia B. B.; RAMIRES, Jose A. F.; KALIL FILHO, Roberto; GIUGLIANO, Robert P.
- Diretrizes Brasileiras de antiagregantes plaquetários e anticoagulantes em cardiologia(2013) LORGA FILHO, A. M.; AZMUS, A. D.; SOEIRO, A. M.; QUADROS, A. S.; AVEZUM JUNIOR, A.; MARQUES, A. C.; FRANCI, A.; MANICA, A. L. L.; VOLSCHAN, A.; V, A. A. De Paola; GRECO, A. I. L.; FERREIRA, A. C. N.; SOUSA, A. C. S.; PESARO, A. E. P.; SIMAO, A. F.; LOPES, A. S. S. A.; TIMERMAN, A.; RAMOS, A. I. O.; ALVES, B. R.; CARAMELLI, B.; MENDES, B. A.; POLANCZYK, C. A.; MONTENEGRO, C. E. L.; BARBOSA, C. J. D. G.; V, C. Serrano Junior; MELO, C. C. L.; PINHO, C.; MOREIRA, D. A. R.; CALDERARO, D.; GUALANDRO, D. M.; ARMAGANIJAN, D.; MACHADO NETO, E. A.; BOCCHI, E. A.; PAIVA, E. F.; STEFANINI, E.; D'AMICO, E.; EVARISTO, E. F.; SILVA, E. E. R.; FERNANDES, F.; BRITO JUNIOR, F. S.; BACAL, F.; GANEM, F.; GOMES, F. L. T.; MATTOS, F. R.; MORAES NETO, F. R.; TARASOUTCHI, F.; DARRIEUX, F. C. C.; FEITOSA, G. S.; FENELON, G.; MORAIS, G. R.; CORREA FILHO, H.; CASTRO, I; GONCALVES JUNIOR, I; ATIE, J.; SOUZA NETO, J. D.; FERREIRA, J. F. M.; NICOLAU, J. C.; FARIA NETO, J. R.; ANNICHINO-BIZZACCHI, J. M.; I, L. Zimerman; PIEGAS, L. S.; PIRES, L. J. T.; BARACIOLI, L. M.; SILVA, L. B.; MATTOS, L. A. P.; LISBOA, L. A. F.; MAGALHAES, L. P. M.; LOPES, M. A. C. Q.; MONTERA, M. W.; FIGUEIREDO, M. J. O.; MALACHIAS, M. V. B.; GAZ, M. V. B.; ANDRADE, M. D.; BACELLAR, M. S. C.; BARBOSA, M. R.; CLAUSELL, N. O.; DUTRA, O. P.; COELHO, O. R.; YU, P. C.; LAVITOLA, P. L.; LEMOS NETO, P. A.; ANDRADE, P. B.; FARSKY, P. S.; FRANCO, R. A.; KALIL, R. A. K.; LOPES, R. D.; ESPORCATTE, R.; HEINISCH, R. H.; KALIL FILHO, R.; V, R. R. C. Giraldez; ALVES, R. C.; LEITE, R. E. G. S.; GAGLIARDI, R. J.; RAMOS, R. F.; MONTENEGRO, S. T.; ACCORSI, T. A. D.; V, T. S. Jardim; SCUDELER, T. L.; MOISES, V. A.; PORTAL, V. L.