ROBERTO EDUARDO BITTAR
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina - Docente
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
LIM/57 - Laboratório de Fisiologia Obstétrica, Hospital das Clínicas, Faculdade de Medicina
65 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 65
- Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo-controlled randomized trial(2017) HERNANDEZ, Wagner R.; FRANCISCO, Rossana P. V.; BITTAR, Roberto E.; GOMEZ, Ursula T.; ZUGAIB, Marcelo; BRIZOT, Maria L.Aim: Our aim was to investigate the effect of the prophylactic use of vaginal progesterone on the latency period from the initiation of tocolytic therapy to delivery in twin pregnancies with preterm labor. Methods: This study was a secondary analysis of a randomized, double-blind, placebo-controlled trial of twin pregnancies in mothers who were exposed to a 200mg vaginal progesterone ovule or a placebo ovule daily from 18 to 34weeks gestation. Patients who were administered tocolysis with Atosiban because of preterm labor were included. The latency from tocolysis to delivery, mean gestational age at delivery and the rates of delivery within 48h and within seven days were compared between progesterone and placebo groups. Results: The analysis included 27 women in the progesterone group and 30 in the placebo group. The baseline characteristics were similar between the groups. Overall, there were no differences in the latency period to delivery (17.5413.54days and 21.58 +/- 13.52days; P=0.289), rates of delivery within 48h (14.8% and 6.7%; P=0.40) or within seven days (29.64% and 23.3%; P=0.76) or mean gestational age at delivery (32.53 +/- 3.33 and 34.13 +/- 2.87; P=0.08) between the progesterone and placebo groups, respectively. Conclusions: Prophylactic use of 200mg of vaginal progesterone does not influence the latency to delivery in women with twin pregnancies treated with tocolysis because of preterm labor.
bookPart Experiências com OSCE em Obstetrícia(2012) BITTAR, Roberto Eduardo; FRANCISCO, Rossana Pulcineli Vieira; GRAZIANO, Marcelo; KOGIMA JUNIOR, Toyoji; ZUGAIB, MarcelobookPart Doença hipertensiva específica da gestação(2020) YOSHIZAKI, Carlos Tadashi; TESTA, Carolina Burgarelli; PAGANOTI, Cristiane de Freitas; MIKAMI, Fernanda Cristina Ferreira; LIN, Lawrence Hsu; BRIZOT, Maria de Lourdes; BORTOLOTTO, Maria Rita de Figueiredo Lemos; CARVALHO, Mário Henrique Burlacchini de; PEREIRA, Pedro Paulo; BITTAR, Roberto Eduardo; MIYADAHIRA, Seizo; MARTINELLI, Silvio; BUNDUKI, VictorbookPart Restrição do crescimento fetal(2016) LIAO, Adolfo Wenjaw; FITTIPALDI, Felipe Silva; LIN, Lawrence Hsu; BERNARDES, Lisandra Stein; BORTOLOTTO, Maria Rita de Figueiredo Lemos; PEREIRA, Pedro Paulo; COSTA, Rafaela Alkmin da; BITTAR, Roberto Eduardo; CODARIN, Rodrigo Rocha- Antenatal Corticosteroid Administration for Reducing the Risk of Neonatal Morbidities from Prematurity(2016) BITTAR, Roberto Eduardo; FRANCISCO, Rossana Pulcineli Vieira; ZUGAIB, Marcelo
- Can cervical length and obstetric history identify asymptomatic women at low risk for preterm birth after a previous preterm birth: a re-analysis of individual patient data(2014) KLEINROUWELER, Emily; JANSEN, Claire Heukensfeldt; OWEN, John; BERGHELLA, Vincenzo; BITTAR, Roberto Eduardo; BAGGA, Rashmi; CRANE, Joan; BOLT, Lauren; ARABIN, Birgit; MOL, Ben Willem; PAJKRT, Eva
- Fetal thrombotic vasculopathy: A case report and literature review(2016) PELEJA, Ana Berquo; MARTINELLI, Silvio; RIBEIRO, Renata Lopes; BITTAR, Roberto Eduardo; SCHULTZ, Regina; FRANCISCO, Rossana Pulcineli VieiraIntroduction: Fetal thrombotic vasculopathy is a recently described placental alteration with varying degrees of involvement and often associated with adverse perinatal outcomes. The diagnosis is made histologically and therefore is postnatal, which makes it a challenge in clinical practice. Method: Case report and review of literature on the subject. Results: The present case refers to a pregnant woman presenting fetal growth restriction, with poor obstetrical past, and sent late to our service. Even with weekly assessments of fetal vitality (fetal biophysical profile and Doppler velocimetry) and prenatal care, the patient progressed with fetal death at 36 weeks and 1 day. There was no association with inherited and acquired thrombophilia. Pathological examination of the placenta revealed fetal thrombotic vasculopathy. Conclusion: The fetal thrombotic vasculopathy may be associated with adverse perinatal outcomes including fetal death, but much remains to be studied regarding its pathogenesis. Diagnosis during pregnancy is not possible and there is still no proven treatment for this condition. Future studies are needed so that strategies can be developed to minimize the impact of fetal thrombotic vasculopathy.
bookPart Prevenção da Prematuridade(2016) BITTAR, Roberto Eduardo; PAGANOTI, Cristiane de Freitas- Comparative analysis of Insulin-like growth factor binding protein-1, placental alpha-microglobulin-1, phenol and pH for the diagnosis of preterm premature rupture of membranes between 20 and 36 weeks(2019) GALLETTA, Marco A. K.; BITTAR, Roberto E.; RODRIGUES, Agatha S.; FRANCISCO, Rossana P. V.; ZUGAIB, MarceloAim Preterm premature rupture of membranes (PPROM) is responsible for approximately one-third of premature births worldwide, and although the diagnosis is often straightforward, this condition can still present difficulties. The purpose of this research was to compare the accuracy of several PPROM diagnostic tests. Methods A total of 94 pregnant women with clinical suspicion of PPROM who were between 20 and 36 weeks of pregnancy were examined by vaginal speculum, and tests were performed for phenol, pH, insulin-like growth factor binding protein-1 (IGFBP-1) and placental alpha-microglobulin-1 (PAMG-1). All patients were followed up until the diagnosis was fully defined, and a diagnosis of PROM was confirmed by a definitive evolution of the clinical symptoms (visualization of vaginal amniotic fluid or persistence of oligohydramnios). Results After excluding the cases that could not be definitively diagnosed, a good diagnostic performance of the immunochromatographic tests was observed that was superior to that of the clinical tests. Similar accuracies were observed for IGFBP-1 (98.7%) and PAMG-1 (93.9%). However, while the IGFBP-1 test differed from a vaginal pH >= 7 (88.9%) and the phenol test (85.7%), this did not occur for the PAMG-1 test. The performance of the tests was modified only by the presence of bleeding (with lower specificity rates for pH and phenol), without interference of gestational age or maternal morbidities. Conclusion Immunochromatographic tests are good tools but should be used sparingly in resource-poor settings because they are expensive, and there is no significant difference between PAMG-1 and traditional tests.
bookPart Hiperêmese(2016) LIAO, Adolfo Wenjaw; FITTIPALDI, Felipe Silva; LIN, Lawrence Hsu; BERNARDES, Lisandra Stein; BORTOLOTTO, Maria Rita de Figueiredo Lemos; PEREIRA, Pedro Paulo; COSTA, Rafaela Alkmin da; BITTAR, Roberto Eduardo; CODARIN, Rodrigo Rocha