PAULO FERREIRA LEITE

Índice h a partir de 2011
2
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Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico

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Agora exibindo 1 - 3 de 3
  • bookPart 14 Citação(ões) na Scopus
    Endothelium-Dependent Vasodilation: Nitric Oxide and Other Mediators
    (2018) LAURINDO, F. R. M.; LIBERMAN, M.; FERNANDES, D. C.; LEITE, P. F.
    Vasodilation is the archetypal function of the endothelial cell and the discovery of paracrine-dependent vasorelaxation by endothelium-derived production of the gaseous mediator nitric oxide (NO) was revolutionary. NO mediates its regulatory vasorelaxing effects through guanilyl cyclase activation. Also, thiol S-nitrosation by NO is increasingly evident as an effector mechanism. Another important NO-related chemistry is its reaction with superoxide radicals, yielding peroxynitrite and related oxidant and nitrating species associated with toxic effects. Nitrogen oxides are storage forms of NO which can exert vasodilation in the presence of hemeproteins. NO generation is mediated by NO synthase enzymes (endothelial, neuronal, and inducible isoforms), which depict complex regulation dependent on cofactors. The absence of such cofactors can uncouple NO generation from electron transfer, generating superoxide. The endothelium additional promotes vasodilation, mainly of small resistance arteries, through endothelium-derived hyperpolarizing factor(s) such as hydrogen peroxide, epoximetabolites of arachidonic acid, and gap junctions. Hydrogen sulfide is a novel gaseous endothelium-derived vasodilator. Together, these mechanisms compose an integrative platform providing an endothelium-associated dilator tone. © 2018 Elsevier Inc. All rights reserved.
  • article 5 Citação(ões) na Scopus
    Poststernotomy aspergillosis: successful treatment with voriconazole, surgical debridement and vacuum-assisted closure therapy
    (2012) SICILIANO, Rinaldo Focaccia; WAISBERG, Daniel Reis; SAMANO, Marcos Naoyuki; LEITE, Paulo Ferreira; TUMA JUNIOR, Paulo; BARREIRO, Guilherme Cardinali; STRABELLI, Tania Mara Varejao
  • bookPart
    Vasodilatação dependente do endotélio: óxido nítrico e outros mediadores
    (2016) LAURINDO, Francisco Rafael Martins; FERNANDES, Denise C.; LIBERMAN, Marcel; LEITE, Paulo Ferreira