OLINDA DO CARMO LUIZ
Projetos de Pesquisa
Unidades Organizacionais
LIM/38 - Laboratório de Epidemiologia e Imunobiologia, Hospital das Clínicas, Faculdade de Medicina
24 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 24
- Sedentary behavior and health outcomes among older adults: a systematic review(2014) REZENDE, Leandro Fornias Machado de; REY-LOPEZ, Juan Pablo; MATSUDO, Victor Keihan Rodrigues; LUIZ, Olinda do CarmoBackground: In the last decade, sedentary behavior has emerged as a new risk factor for health. The elderly spend most of their awake time in sedentary activities. Despite this high exposure, the impact of this sedentary behavior on the health of this population has not yet been reviewed. We systematically reviewed evidence for associations between sedentary behavior and multiple health outcomes in adults over 60 years of age. Methods: We searched the Medline, Embase, Web of Science, SPORTDiscus, PsycINFO, CINAHL, LILLACS, and Sedentary Research Database for observational studies published up to May 2013. Additionally, we contacted members of the Sedentary Behaviour Research Network to identify articles that were potentially eligible. After inclusion, the methodological quality of the evidence was assessed in each study. Results: We included 24 eligible articles in our systematic review, of which only 2 (8%) provided high-quality evidence. Greater sedentary time was related to an increased risk of all-cause mortality in the older adults. Some studies with a moderate quality of evidence indicated a relationship between sedentary behavior and metabolic syndrome, waist circumference, and overweightness/obesity. The findings for other outcomes such as mental health, renal cancer cells, and falls remain insufficient to draw conclusions. Conclusion: This systematic review supports the relationship between sedentary behavior and mortality in older adults. Additional studies with high methodological quality are still needed to develop informed guidelines for addressing sedentary behavior in older adults.
- Sociodemographic and behavioral factors associated with physical activity in Brazilian adolescents(2014) REZENDE, Leandro Fornias Machado de; AZEREDO, Catarina Machado; CANELLA, Daniela Silva; CLARO, Rafael Moreira; CASTRO, Ines Rugani Ribeiro de; LEVY, Renata Bertazzi; LUIZ, Olinda do CarmoBackground: Physical activity in adolescents is associated with short-and long-term health benefits. Physical activity can occur in various domains and is influenced by a complex network of factors. The aims of this study are 1) to describe the physical activity of Brazilian adolescents in physical education classes, during leisure time, and during active commuting and 2) to investigate the socio-demographic and behavioral factors associated with physical activity. Methods: The representative sample included 109,104 Brazilian students in the final year of elementary school from 2,842 schools. The weekly frequency and duration of physical activity were assessed. A variety of socio-demographic and behavioral factors were studied. A multiple Poisson regression analysis was used to test for associations between physical activity and the socio-demographic and behavioral variables. Results: Most of the students (97.0%) engaged in physical activity in at least one of the domains studied, especially physical education at school (81.7%) and leisure time physical activity (67.5%). However, only 29% of the adolescents reached the recommended level of physical activity. Among the adolescents who reached the minimum recommended time for physical activity, the various domains contributed the following proportions to total physical activity: leisure time physical activity (PR 12.5; 95% CI 11.17-13.97), active commuting (PR 1.63; 95% CI 1.59-1.67), and physical education at school (PR 1.36; 95% CI 1.29-1.44). The weekly frequency of all activities was greater among boys than among girls. Moreover, nearly two-thirds (61.8%) of students spent more than two hours per day engaging in sedentary behaviors; the prevalence of sedentary behaviors was similar between boys and girls (59.0 and 64.5%, respectively). Total level of physical activity, leisure time physical activity, and active commuting were associated with higher nutritional scores. Conclusions: Physical activity is important in any health promotion program. Therefore, it is necessary to invest in policies and interagency initiatives that promote all domains and to ensure that the general population helps determine the scope and design of such policies.
- Tendência temporal da participação em atividade física no lazer na cidade de Curitiba, Brasil (2006-2015)(2019) LIMA, Dartel Ferrari de; SILVA, Michael Pereira da; MAZZARDO, Oldemar; LIMA, Lohran Anguera; SAMPAIO, Adelar Aparecido; ANGUERA, Maria das Graças; LUIZ, Olinda do CarmoABSTRACT: Objective: The identification of the time trend of physical activity can help in the evaluation of the effectiveness of programs aimed at the promotion of physical activity at the population scope. To analyze the temporal trend of leisure time physical activity in adults living in the city of Curitiba (Brazil), from 2006-2015. Methods: This is a cross-sectional study with 19,183 adults, obtaining information on duration, intensity and weekly frequency of leisure-time physical activity from the Surveillance System of Risk and Protection Factors for Chronic Diseases by Telephone Inquiry. Adults who reported participating in leisure time physical activity at least once a week in the three months prior to the survey were considered active. Results: Men’s leisure-time physical activity was stable overtime (p = 0.28), while it increased significantly among women (1.86% per year, 95%CI 0.55; 3.37; p = 0.02). Men reported less activities with weekly frequency of one to two times (-3.75% per year, 95%CI -6.72; -0.67; p = 0.03) but more with weekly frequencies of five to six times (7.42% per year, 95%CI 4.54; 10.38; p = 0.001). No changes were observed in the frequency of physical activity among women. Conclusion: Monitoring indicators of physical activity in the city of Curitiba can assist legislators in building policies to promote physical activity
- Human papillomavirus infection in oral fluids of HIV-1-positive men: prevalence and risk factors(2014) GAESTER, Karen; FONSECA, Luiz A. M.; LUIZ, Olinda; ASSONE, Tatiane; FONTES, Adriele Souza; COSTA, Fernando; DUARTE, Alberto J. S.; CASSEB, JorgeHuman papillomavirus is one of the most common sexually transmitted diseases worldwide. The natural history of oral HPV infection is unclear, and its risk factors have not been explored. Immunocompromised individuals, as exemplified by HIV patients, are at high risk for HPV-related diseases. The mean of this study is to determine the prevalence ofHPV in the oral tract of HIV-1-positive male subjects and its association with risk factors. A total of 283 oral wash samples from HIV-1-positive men were tested. The oral fluid samples were used for DNA extraction and conventional PCR amplification; HPV genotyping was performed by hybridization. HPV genotyping revealed that nine samples (3.5%) were positive for HPV DNA; the major high-risk HPV types identified were 51 and 66. Worldwide studies have shown a variable prevalence of oral HPV. The diversity of genotypes and the high prevalence of multiple infections in HIV-infected subjects can be better explained by the effects of HIV-induced immunosuppression. The most important risk factors are unprotected sexual intercourse, but other factors for this infection have been described elsewhere including smoking, age and HIV-positive serostatus. In this study, smoking was the most important risk factor for acquiring oral HPV in HIV-1-infected subjects in Brazil.
- Polymorphism in the Promoter Region of theIL18Gene and the Association With Severity on Paracoccidioidomycosis(2020) SATO, Paula Keiko; BUSSER, Felipe Delatorre; CARVALHO, Flavia Mendes da Cunha; SANTOS, Alexandra Gomes dos; SADAHIRO, Aya; DIOGO, Constancia Lima; KONO, Adriana Satie Goncalves; MORETTI, Maria Luiza; LUIZ, Olinda do Carmo; SHIKANAI-YASUDA, Maria AparecidaParacoccidioidomycosis (PCM) is an important endemic, systemic disease in Latin America caused byParacoccidioidesspp. This mycosis has been associated with high morbidity and sequels, and its clinical manifestations depend on the virulence of the infecting strain, the degree and type of immune response, infected tissues, and intrinsic characteristics of the host. The T helper(Th)1 and Th17/Th22 cells are related to resistance and control of infection, and a Th2/Th9 response is associated with disease susceptibility. In this study, we focused on interleukin(IL)-12p35 (IL12A), IL-18 (IL18), and IFN-gamma receptor 1 (IFNGR1) genetic polymorphisms because their respective roles have been described in human PCM. Real-time PCR was employed to analyzeIL12A-504 G/T (rs2243115),IL18-607 C/A (rs1946518), andIFNGR1-611 A/G (rs1327474) single nucleotide polymorphisms (SNP). One hundred forty-nine patients with the acute form (AF), multifocal chronic (MC), or unifocal chronic (UC) forms of PCM and 110 non-PCM individuals as a control group were included. In the unconditional logistic regression analysis adjusted by ethnicity and sex, we observed a high risk of theIL18-607A-allele for both AF [p= 0.015; OR = 3.10 (95% CI: 1.24-7.77)] and MC groups [p= 0.023; OR = 2.61 (95% CI: 1.14-5.96)] when compared with UC. TheIL18-607A-allele associated risk for the AF and MC groups as well as the protective role of theC-allele in UC are possibly linked to higher levels of IL-18 at different periods of the course of the disease. Therefore, a novel role ofIL18-607 C/A SNP is shown in the present study, highlighting its importance in the outcome of PCM.
- The contribution of intersectionality on understanding young men's health-disease and care in contexts of urban poverty(2020) OLIVEIRA, Elda de; COUTO, Marcia Thereza; SEPARAVICH, Marco Antonio Alves; LUIZ, Olinda do CarmoThis article analyzes the experiences of young men living in the city outskirts regarding social inequalities and their impacts on the health-disease-care production process. The empirical material that supports the intersectional analysis was produced with a qualitative methodology of research-action based on workshops, a group technique with participatory investigations. A total of 21 men and five women aged between 15 and 17 years who studied at a neighborhood public school of the Brazilian city of Sao Paulo, state of Sao Paulo, participated in the study. The results highlight that young men share intertwined race-color, class, gender, and generation disadvantages that act in a complex way in the production of social and health inequalities. Therefore, analyses that restrict inequalities to a single classificatory system-class, gender, or race/color-are inadequate to understand the various dimensions that comprise them.
- Race and obesity in the black female population: a scoping review(2020) ORAKA, Claudia Simoes; FAUSTINO, Deivison Mendes; OLIVEIRA, Elda; TEIXEIRA, Joao Alexandre Mendes; SOUZA, Allex Sander Porfirio de; LUIZ, Olinda do CarmoAbout 40% of the world's population is overweight. Obesity is most prevalent among social strata with lower income and education. Although the association between sociodemographic factors and weight gain is well documented, few researchers associated obesity with race/color. This article aims to map the extent, scope, and nature of the association between obesity and race in the scientific literature by conducting a scoping review. Data sources were the Literature Analysis and Retrieval System Online (Medline), Excerpta Medica Database (Embase), Web of Science, Health InterNetwork Access to Research Initiative (Hinari), and Scopus databases, as well as the gray literature. In total, 2,526 articles were found. After duplicates were excluded and inclusion and exclusion criteria applied, 10 articles remained. Race, obesity, socioeconomic status, and gender are tied into a complex relationship whose specificity lies on the socio-historical context. Racial disparities in obesity may be explained by physiological, psychological, and cultural effects of stress due to racial discrimination. Although racial inequality happens everywhere, it assumes different forms. Considering that, further studies should approach regional differences.
- Sedentary Behavior and Health Outcomes: An Overview of Systematic Reviews(2014) REZENDE, Leandro Fornias Machado de; LOPES, Mauricio Rodrigues; REY-LOPEZ, Juan Pablo; MATSUDO, Victor Keihan Rodrigues; LUIZ, Olinda do CarmoObjective: 1) To synthesize the current observational evidence for the association between sedentary behavior and health outcomes using information from systematic reviews. 2) To assess the methodological quality of the systematic reviews found. Methodology/Principal Findings: Medline; Excerpta Medica (Embase); PsycINFO; and Web of Science were searched for reviews published up to September 2013. Additional publications were provided by Sedentary Behaviour Research Network members. The methodological quality of the systematic reviews was evaluated using recommended standard criteria from AMSTAR. For each review, improper use of causal language in the description of their main results/conclusion was evaluated. Altogether, 1,044 review titles were identified, 144 were read in their entirety, and 27 were included. Based on the systematic reviews with the best methodological quality, we found in children and adolescents, strong evidence of a relationship between time spent in sedentary behavior and obesity. Moreover, moderate evidence was observed for blood pressure and total cholesterol, self-esteem, social behavior problems, physical fitness and academic achievement. In adults, we found strong evidence of a relationship between sedentary behavior and all-cause mortality, fatal and non-fatal cardiovascular disease, type 2 diabetes and metabolic syndrome. In addition, there is moderate evidence for incidence rates of ovarian, colon and endometrial cancers. Conclusions: This overview based on the best available systematics reviews, shows that sedentary behavior may be an important determinant of health, independently of physical activity. However, the relationship is complex because it depends on the type of sedentary behavior and the age group studied. The relationship between sedentary behavior and many health outcomes remains uncertain; thus, further studies are warranted.
- Structural determinants of health, race, gender, and social class: a scope review(2021) GALVAO, Anna Larice Meneses; OLIVEIRA, Elda; GERMANI, Ana Claudia Camargo Goncalves; LUIZ, Olinda do CarmoThis article aims at exploring and systematizing the knowledge about structural health determinants. For such purpose, we developed a scope review in the databases Web of Science, Cinahl, Scopus, Lilacs and PubMed; and in the journals International Journal of Epidemiology,Journal of Epidemiology and Community Health,American Journal of Public Health and American Journal of Epidemiology from 2005 to 2018. We used the search terms ""Social Determinants of health"", ""Health services"", ""health policies"", and""inequity"". We identified 1,164 articles, of which 19 were selected. The structural determinants, also called social markers, were race, gender, gender identity, migration and social class. Theoretical perspectives of these articles, directly or indirectly,assumed health as a right. The proposed health policies focused on the positive effect of planning functions, training of service providers, and reduction of barriers to access and participation of excluded groups on equity. We concluded that the scientific literature reinforces that every individual must have the capacity to reach a personal ideal state of health without any distinction of race, skin color, religion,language, nationality, socioeconomic resources, genre, sexual orientation, gender identity,physical, mental or emotional disability, or any other characteristic linked to discrimination or exclusion from social and political opportunities.
- Ethnicity and Cutaneous Melanoma in the City of Sao Paulo, Brazil: A Case-Control Study(2012) LUIZ, Olinda C.; GIANINI, Reinaldo Jose; GONCALVES, Fernanda T.; FRANCISCO, Guilherme; FESTA-NETO, Cyro; SANCHES, Jose Antonio; GATTAS, Gilka J. F.; CHAMMAS, Roger; ELUF-NETO, JoseBackground: Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogenous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil. Methodology/Principal Findings: We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe-Spain (OR = 3.01, 95% CI: 1.03-8.77), Italy (OR = 3.47, 95% CI: 1.41-8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05-8.93), or >= 2 European countries (OR = 2.82, 95% CI: 1.06-7.47); eye color-light brown (OR = 1.99, 95% CI: 1.14-3.84) and green/blue (OR = 4.62; 95% CI 2.22-9.58); pigmented lesion removal (OR = 3.78; 95% CI: 2.21-6.49); no lifetime sunscreen use (OR = 3.08; 95% CI: 1.03-9.22); and lifetime severe sunburn (OR = 1.81; 95% CI: 1.03-3.19). Conclusions: Our results indicate that European ancestry is a risk factor for cutaneous melanoma. Such risk appears to be related not only to skin type, eye color, and tanning capacity but also to others specific characteristics of European populations introduced in the New World by European immigrants.
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