LUCIANA DE PAULA SAMORANO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
41 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 41
bookPart Mastocitose(2022) SAMORANO, Luciana de Paula; VIEIRA, Marina Lino- Sweet Syndrome: Clinical Features, Histopathology, and Associations of 83 Cases(2017) COSTA, Jose Ricardo Casarin; VIRGENS, Anangelica Rodrigues; MESTRE, Luisa de Oliveira; DIAS, Natasha Favoretto; SAMORANO, Luciana Paula; VALENTE, Neusa Yuriko Sakai; FESTA NETO, CyroBackground: Sweet syndrome (SS) is an infrequent skin disease characterised by sudden onset of fever, leukocytosis, neutrophilia, and tender erythematous plaques infiltrated by neutrophils. Multiple conditions have been associated with this syndrome. Objectives: The aim of this study was to evaluate the clinical, epidemiological, laboratory, and histopathological findings and associations of patients with SS. Methods: We conducted a retrospective study of 83 patients with SS followed between January 1, 2006, and January 31, 2015. Results: Of the patients, 82% were female; the mean age at onset was 48 years. Clinical presentation was mainly characterised by erythematous and edematous plaques, mostly on upper extremities and trunk. Fever was observed in 32%; 60% presented leukocytosis and 39% neutrophilia. On histopathological examination, neutrophilic and lymphohistiocytic infiltrate and edema were the most frequent findings. Fourteen percent of patients had malignancy or hematologic disorders, 26% were classified as having drug-induced SS, and 24% noted recent infection. Only 2 cases occurred during pregnancy. Systemic corticosteroid was the most common choice of treatment, with excellent response. In malignancy-associated SS, the mean hemoglobin level was lower (P = .01) and the erythrocyte sedimentation rate (ESR) was higher (P = .04) in comparison to classic and drug-induced SS. Leukocytoclasia was associated with higher risk of recurrence (P = .01). Conclusion: All patients with SS deserve careful investigation of possible underlying conditions. Higher ESR and lower hemoglobin levels might reinforce the need of malignancy screening. Also, leukocytoclasia appears to be a potential marker of higher recurrence rate, demanding closer and longer follow-up.
bookPart Fotoproteção(2022) MIOTTO, Isadora Zago; SAMORANO, Luciana de Paula; OLIVEIRA, Zilda Najjar Prado de- Tuberous sclerosis complex: review based on new diagnostic criteria(2018) PORTOCARRERO, Larissa Karine Leite; QUENTAL, Klicia Novais; SAMORANO, Luciana Paula; OLIVEIRA, Zilda Najjar Prado de; RIVITTI-MACHADO, Maria Cecilia da MattaTuberous sclerosis complex is a multisystemic, autosomal dominant genetic disorder with complete penetrance, that can evolve with hamartomas in multiple organs, such as skin, central nervous system, kidney and lung. Due to the wide phenotypic variability, the disease is often not recognized. Tuberous sclerosis complex affects one in 10,000 newborns and most patients are diagnosed during the first 15 months of life. The diagnostic criteria for tuberous sclerosis were reviewed in 2012, at the second International Tuberous Sclerosis Complex Consensus Conference. The diagnosis is based on genetic criteria, by the identification of inactivating pathogenic mutation of tumor suppressor genes TSC1 and TSC2, and clinical criteria, including cutaneous, renal, pulmonary, cardiac and neurological manifestations. The treatment of tuberous sclerosis complex consists, mainly, in management of the symptoms caused by hamartomas and in prevention of organ failure. Multidisciplinary approach is recommended, in order to obtain better clinical outcomes.
- Profile of patients admitted to a triage dermatology clinic at a tertiary hospital in Sao Paulo, Brazil(2016) BERTANHA, Fernanda; NELUMBA, Erica Judite Pimentel; FREIBERG, Alyne Korukian; SAMORANO, Luciana Paula; NETO, Cyro FestaBackground: Knowledge of epidemiological data on skin diseases is important in planning preventive strategies in healthcare services. OBJECTIVE: To assess data from patients admitted to a triage dermatology clinic. METHODS: A retrospective study was performed of patients admitted over a one-year period to the Triage Dermatology Clinic at the Hospital das Clinicas of the University of Sao Paulo Medical School. Data were obtained from record books. The variables analyzed were: patient age, gender, dermatologic disease (initial diagnosis), origin (from where the patient was referred) and destination (where the patient was referred to). RESULTS: A total of 16,399 patients and 17,454 diseases were identified for analysis. The most frequent skin disorders were eczema (18%), cutaneous infections (13.1%), erythematous squamous diseases (6.8%) and malignant cutaneous neoplasms (6.1%). Atopic dermatitis was the most common disease in children. Acne was more common among children and adults, as were viral warts. Basal cell carcinoma and squamous cell carcinoma were more common in the elderly. Contact dermatitis and acne predominated in women. The most frequent origins were: the primary/secondary health system (26.6%), other outpatient specialties (25.5%), emergency care (14.9%); while the destinations were: discharged (27.5%), follow-up in our Dermatology Division (24.1%), return (14.1%) and the primary/secondary health system (20.7%). CONCLUSION: Understanding the incidence of skin diseases is fundamental in making decisions regarding resource allocation for clinical care and research. Thus, we believe our findings can contribute to improving public health policies.
- Skin barrier in atopic dermatitis: beyond filaggrin(2016) ZANIBONI, Mariana Colombini; SAMORANO, Luciana Paula; ORFALI, Raquel Leao; AOKI, ValeriaAtopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors. The skin forms a mechanic and immune barrier, regulating water loss from the internal to the external environment, and protecting the individual from external aggressions, such as microorganisms, ultraviolet radiation and physical trauma. Main components of the skin barrier are located in the outer layers of the epidermis (such as filaggrin), the proteins that form the tight junction (TJ) and components of the innate immune system. Recent data involving skin barrier reveal new information regarding its structure and its role in the mechanic-immunological defense; atopic dermatitis (AD) is an example of a disease related to dysfunctions associated with this complex.
conferenceObject Darier disease: Long-term treatment with systemic retinoids at a tertiary hospital(2020) VIEIRA, Marina Lino; OLIVEIRA, Zilda Najjar Prado de; SAMORANO, Luciana Paula; PESS, Daiana; RIVITTI-MACHADO, Maria Cecilia- Methotrexate for atopic dermatitis in adults: a prospective study from a reference center in Brazil(2021) SAMORANO, Luciana Paula; TAKAOKA, Roberto; ZANIBONI, Mariana Colombini; AOKI, Valeria
- Underrecognition of epidermolysis bullosa pruriginosa(2015) CHA, Caroline Coronado; SAMORANO, Luciana Paula; DACACHE, Fernanda Motta; RIVITTI-MACHADO, Maria Cecilia da Matta; OLIVEIRA, Zilda Najjar Prado de
- Corticosteroid use in urticaria multiforme cases Response(2017) SAMORANO, Luciana P.; FERNANDEZ, Vanessa V.; VALENTE, Neusa Y. S.; ARNONE, Marcelo; NICO, Marcello M. S.; RIVITTI-MACHADO, Maria C. M.; OLIVEIRA, Zilda N. P.; CRIADO, Paulo R.