ISADORA ZAGO MIOTTO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
13 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 13
bookPart Fotoproteção(2022) MIOTTO, Isadora Zago; SAMORANO, Luciana de Paula; OLIVEIRA, Zilda Najjar Prado de- Evidence for lymphocytic inflammation in non-lesional scalp of folliculitis decalvans: an observational study of 25 patients(2022) DOCHE, I.; HORDINSKY, M. K.; VALENTE, N. S.; SOTTO, M. N.; MIOTTO, I.; REBEIS, M.; RIVITTI-MACHADO, M. C.
- Cutaneous infections from viral sources in solid organ transplant recipients(2023) MIOTTO, Isadora Zago; NETO, Cyro Festa; OLIVEIRA, Walmar Roncalli Pereira deIntroduction: Solid organ transplant recipients (SOTRs) are susceptible to various dermatological complications caused by long-term immunosuppressive therapy. Of these complications, viral infections are noteworthy because of their high prevalence and the potential morbidity associated with viral carcinogenesis.Objectives: To evaluate the occurrence of cutaneous viral infections in SOTRs and their correlation with clinical features, transplant type, and the length and intensity of immunosuppressive therapy. Methods: This retrospective cohort study included SOTRs followed up at the Department of Dermatology in a tertiary hospital. The outcomes analyzed were the occurrence of cutaneous viral infections, including human papillomavirus (HPV) infection, herpes simplex, herpes zoster, molluscum contagiosum, Merkel cell carcinoma, Kaposi's sarcoma, and cytomegalovirus, and the occurrence of HPV-related neoplasms. Clinical variables, such as length and intensity of immunosuppression, type of transplanted organ, and comorbidities, were analyzed as possible risk factors for cutaneous viral infections in SOTRs.Results: A total of 528 SOTRs were included in this study, among which 53.8% had one or more viral infections. Of these, 10% developed a virus-associated malignancy (HPV-associated carcinoma, Merkel cell carcinoma, or Kaposi's sarcoma). The higher risk of viral infections among SOTRs was associated with cyclosporine intake (1.40-fold higher risk) and younger age at transplantation. The use of an immunosuppressive regimen, including additional drugs, was associated with a higher risk of genital HPV infection (1.50-fold higher risk for each in-cremental drug).Conclusions: The occurrence of cutaneous viral infections in SOTRs is directly associated with the duration and intensity of immunosuppressive therapy. Patients at higher risk were those taking drugs with a stronger impact on cellular immunity and/or those on an immunosuppressive regimen comprising various drugs.
article 1 Citação(ões) na Scopus Epidermodysplasia verruciformis: Report of two patients with autosomal dominant inheritance(2021) MIOTTO, I. Z.; OLIVEIRA, W. R. P. deEpidermodysplasia verruciformis is a rare genodermatosis associated with mutations in the EVER1/TMC6 and EVER2/TMC8 genes. The inheritance is considered to be autosomal recessive, but reports suggesting an autosomal dominant inheritance indicate disease genetic heterogeneity. Its onset occurs in early childhood and presents as a combination of pityriasis versicolor-like, flat wart-like and seborrheic keratosis-like lesions, with a potential for malignant transformation, mainly squamous cell carcinoma. © 2021 Dermatology Online Journal. All rights reserved.- Cutaneous Side Effects of Immunosuppressive Drugs Other Than Neoplasms(2022) MIOTTO, I. Z.; OLIVEIRA, W. R. P. deSolid organ transplant recipients are susceptible to various dermatological side effects as a consequence of long-term immunosuppressive therapy. Malignancies and infections are well-studied complications, but there is less information regarding other nonmalignant skin changes, such as inflammatory manifestations. The aim of this chapter is to describe the cutaneous side effects related to the following drugs: Systemic steroids, azathioprine, mycophenolate mofetil, cyclosporine, tacrolimus, mTOR inhibitors (sirolimus and everolimus), and newer agents, such as monoclonal antibodies and biologic drugs. Transplant care providers must be able to recognize and properly manage these cutaneous findings in order to limit associated morbidity and mortality. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
- Trichoscopic and imaging study of lipedematous alopecia: report of five cases(2020) DOCHE, I.; MIOTTO, I.; RIVITTI-MACHADO, M. C.; MELO, D. F.; LARRONDO, J.; CABRERA, R.; RAJABI-ESTARABADI, A.; TOSTI, A.
- Granulomatous slack skin: A series of cases(2018) MIOTTO, Isadora; MIYASHIRO, Denis; MARTINS, Jade; SANCHES, Jose Antonio
- Sexually Transmitted Infections(2022) MIOTTO, I. Z.; OLIVEIRA, W. R. P. deSexually transmitted infections (STIs) represent a significant global public health burden, with approximately 1 million new cases daily. Systematic serology screening for STIs is generally performed in transplant donors and recipients, which include testing for human immunodeficiency virus (HIV), viral hepatitis B and C, herpes simplex virus, and syphilis. Infection by human papillomavirus (HPV) should be properly recognized by clinical and histopathological examination, once lesions can undergo malignant transformation. STIs in solid organ transplant recipients (SOTRs) may have an atypical presentation and tricky diagnosis. Transplant caregivers must be aware of these peculiarities, and patients must be followed-up closely, in order to reduce associated morbidity. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
bookPart Esclerose(2019) ROSAN, Isadora; MIOTTO, Isadora; ROMITI, Ricardo- Immunosuppressant-induced cutaneous drug reactions in solid organ transplant recipients(2021) MIOTTO, Isadora Zago; SOUZA, Bruno de Castro e; TYRING, Stephen K.; OLIVEIRA, Walmar Roncalli Pereira deSolid organ transplant recipients (SOTRs) are susceptible to various cutaneous side effects as a consequence of long-term immunosuppressive therapy. Skin cancers and infections are well-studied complications that can cause death and/or allograft rejection. Other cutaneous drug reactions, such as inflammatory manifestations, have a high prevalence but are rarely studied. We analyzed these manifestations' prevalence and their association with immunosuppressants in transplant recipients from a Brazilian tertiary center. Among 532 SOTRs followed at our dermatology clinic, 60 (11.3%) developed some cutaneous adverse reactions to the immunosuppressants, with a median age at transplantation of 50.5 years and a median life span posttransplantation of seven years. Acneiform eruption was the most common drug reaction found (21 patients, 30.4%), followed by diffuse non-scarring alopecia (16 patients, 23.1%), lymphedema (10 patients, 14.5%), gingival hyperplasia (7 patients, 10.1%), hypertrichosis (6 patients, 8.7%) and sebaceous hyperplasia (9 patients, 13.1%). Adequate immunosuppression is an essential prerequisite for successful organ transplantation. In the immediate post-transplant period, significant immunosuppression is needed, but after that, the complications of excessive immunosuppression outweigh the risk of organ rejection. SORTs may present with a broad spectrum of inflammatory and cosmetic findings due to immunosuppressants that can impair life quality.