Interleukin-15 and Interleukin-7 are the Major Cytokines to Maintain Endometriosis

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Citações na Scopus
18
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
KARGER
Autores
GUEUVOGHLANIAN-SILVA, Barbara Yasmin
Citação
GYNECOLOGIC AND OBSTETRIC INVESTIGATION, v.84, n.5, p.435-444, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: The objective of this study was to evaluate cytokines related to natural killer and T-regulatory cells in endometriotic lesions, peritoneal fluid (PF) and the peripheral blood (PB) of patients with deep infiltrative endometriosis. Study Design: A case-control study was conducted in a tertiary referral hospital. Sixty-four consecutive patients after laparoscopy were divided into 2 groups: with endometriosis (Group A - n = 32) and without endometriosis (Group B - n = 32). Main Outcome Measures: Interleukin (IL)-2, IL-4, IL-7, IL-10, IL-12, IL-15, transforming growth factor beta 1, and IFN gamma concentration was measured using a Luminex(TM) multiplex suspension bead array. Tissues from endometriotic lesions of patients with endometriosis and from eutopic endometrium were evaluated, as well as PF and PB of all patients. Results: Compared to the other analyzed groups, IL-15 concentration was significantly higher in the ectopic endometrium and IL-7 in the eutopic endometrium of the endometriosis group (p < 0.05). Compared to endometriosis group, IFN gamma, IL-7, and IL-15 were observed to be significantly higher in the PF of the control group, and IL-10 was lower in the control group (p < 0.05). In PB, compared to endometriosis group, IL-4, IL-10, IL-12, IL-15, and IFN gamma concentrations were significantly higher in the control group (p < 0.05). Conclusions: Our hypothesis is that deep endometriosis is a disease out of control. This disease's nature is of progression and invasion of adjacent structures, and proof of this disease state is the disorganized secretion of cytokine regulation and inflammation, which seem to be among the factors responsible for the maintenance of the disease.
Palavras-chave
Endometriosis, Natural killer cells, T-Regulatory cells, Cytokines, Endometrium
URI
https://observatorio.fm.usp.br/handle/OPI/33924
Referências
  1. Abbas A, 2011, IMUNOLOGIA CELULAR M, P55
  2. Acien Pedro, 2013, ISRN Obstet Gynecol, V2013, P242149, DOI 10.1155/2013/242149
  3. Bellelis P, 2013, FERTIL STERIL, V99, P1987, DOI 10.1016/j.fertnstert.2013.02.038
  4. Bellelis P, 2010, REV ASSOC MED BRAS, V56, P467, DOI 10.1590/S0104-42302010000400022
  5. Berbic M, 2013, WOMENS HEALTH, V9, P387, DOI [10.2217/WHE.13.32, 10.2217/whe.13.32]
  6. Berkkanoglu M, 2003, AM J REPROD IMMUNOL, V50, P48, DOI 10.1034/j.1600-0897.2003.00042.x
  7. Dias JA, 2012, J MINIM INVAS GYN, V19, P317, DOI 10.1016/j.jmig.2011.12.021
  8. Fairbanks F, 2009, FERTIL STERIL, V91, P320, DOI 10.1016/j.fertnstert.2007.11.060
  9. Fehniger TA, 2001, BLOOD, V97, P14, DOI 10.1182/blood.V97.1.14
  10. Gao X, 2006, CURR MED RES OPIN, V22, P1787, DOI 10.1185/030079906X121084
  11. Gueuvoghlanian-Silva BY, 2018, J REPROD IMMUNOL, V126, P32, DOI 10.1016/j.jri.2018.02.003
  12. Guo Saiqun, 2012, Nan Fang Yi Ke Da Xue Xue Bao, V32, P1322
  13. Harada T, 2001, FERTIL STERIL, V76, P1, DOI 10.1016/S0015-0282(01)01816-7
  14. King A, 1996, NAT IMMUN, V15, P41
  15. Li MQ, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2014.414
  16. Lin SJ, 2014, METHODS MOL BIOL, V1139, P223, DOI 10.1007/978-1-4939-0345-0_19
  17. Ma A, 2006, ANNU REV IMMUNOL, V24, P657, DOI 10.1146/annurev.immunol.24.021605.090727
  18. Meyer R, 1919, ZBL GYNAKOL, P745
  19. Mier-Cabrera J, 2011, BJOG-INT J OBSTET GY, V118, P6, DOI 10.1111/j.1471-0528.2010.02777.x
  20. Monsanto SP, 2016, FERTIL STERIL, V105, P968, DOI 10.1016/j.fertnstert.2015.11.047
  21. Othman EEDR, 2008, EUR J OBSTET GYN R B, V137, P240, DOI 10.1016/j.ejogrb.2007.05.001
  22. Pagliari D, 2013, CYTOKINE GROWTH F R, V24, P455, DOI 10.1016/j.cytogfr.2013.05.004
  23. Podgaec S, 2007, HUM REPROD, V22, P1373, DOI 10.1093/humrep/del516
  24. Podgaec S, 2014, J REPROD IMMUNOL, V104, P96, DOI 10.1016/j.jri.2014.05.002
  25. Podgaec S, 2012, AM J REPROD IMMUNOL, V68, P301, DOI 10.1111/j.1600-0897.2012.01173.x
  26. Read KA, 2016, EXP HEMATOL, V44, P799, DOI 10.1016/j.exphem.2016.06.003
  27. Sampson JA, 1927, AM J OBSTET GYNECOL, V14, P422, DOI 10.1016/S0002-9378(15)30003-X
  28. Tosti C, 2015, REPROD SCI, V22, P1053, DOI 10.1177/1933719115592713
  29. Yu JJ, 2016, REPRODUCTION, V152, P151, DOI 10.1530/REP-16-0089

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MOG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/19
Artigos e Materiais de Revistas Científicas - LIM/51
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