Risk Factors for the Impairment of Ambulation in Older People Hospitalized with COVID-19: A Retrospective Cohort Study

Nenhuma Miniatura disponível
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
MULTIDISCIPLINARY DIGITAL PUBLISHING INSTITUTE (MDPI)
Citação
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.20, n.22, article ID 7057, p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
(1) Background: Some older people hospitalized with COVID-19 have experienced reduced ambulation capacity. However, the prevalence of the impairment of ambulation capacity still needs to be established. Objective: To estimate the prevalence of, and identify the risk factors associated with, the impairment of ambulation capacity at the point of hospital discharge for older people with COVID-19. (2) Methods: A retrospective cohort study. Included are those with an age > 60 years, of either sex, hospitalized due to COVID-19. Clinical data was collected from patients’ medical records. Ambulation capacity prior to COVID-19 infection was assessed through the patients’ reports from their relatives. Multiple logistic regressions were performed to identify the risk factors associated with the impairment of ambulation at hospital discharge. (3) Results: Data for 429 older people hospitalized with COVID-19 were randomly collected from the medical records. Among the 56.4% who were discharged, 57.9% had reduced ambulation capacity. Factors associated with reduced ambulation capacity at discharge were a hospital stay longer than 20 days (Odds Ratio (OR): 3.5) and dependent ambulation capacity prior to COVID-19 (Odds Ratio (OR): 11.3). (4) Conclusion: More than half of the older people who survived following hospitalization due to COVID-19 had reduced ambulation capacity at hospital discharge. Impaired ambulation prior to the infection and a longer hospital stay were risks factors for reduced ambulation capacity.
Palavras-chave
COVID-19, functional status, hospitalization, older people
Referências
  1. Zisberg A., Shadmi E., Sinoff G., Gur-Yaish N., Srulovici E., Admi H., Low mobility during hospitalization and functional decline in older adults, J. Am. Geriatr. Soc, 59, pp. 266-273, (2011)
  2. Mahoney J.E., Sager M.A., Jalaluddin M., New walking dependence associated with hospitalization for acute medical illness: Incidence and significance, J. Gerontol. A Biol. Sci. Med. Sci, 53, pp. M307-M312, (1998)
  3. Medina-Mirapeix F., Bernabeu-Mora R., Garcia-Guillamon G., Valera Novella E., Gacto-Sanchez M., Garcia-Vidal J.A., Patterns, Trajectories, and Predictors of Functional Decline after Hospitalization for Acute Exacerbations in Men with Moderate to Severe Chronic Obstructive Pulmonary Disease: A Longitudinal Study, PLoS ONE, 11, (2016)
  4. Coppo A., Bellani G., Winterton D., Di Pierro M., Soria A., Faverio P., Cairo M., Mori S., Messinesi G., Contro E., Et al., Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): A prospective cohort study, Lancet Respir. Med, 8, pp. 765-774, (2020)
  5. Morley J.E., Vellas B., Editorial: COVID-19 and Older Adults, J. Nutr. Health Aging, 24, pp. 364-365, (2020)
  6. Williamson E.J., Walker A.J., Bhaskaran K., Bacon S., Bates C., Morton C.E., Curtis H.J., Mehrkar A., Evans D., Inglesby P., Et al., Factors associated with COVID-19-related death using Open SAFELY, Nature, 84, pp. 430-436, (2020)
  7. Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), (2020)
  8. Grant M.C., Geoghegan L., Arbyn M., Mohammed Z., McGuinness L., Clarke E.L., Wade R.G., The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2
  9. COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries, PLoS ONE, 15, (2020)
  10. Meo S.A., Al-Khlaiwi T., Usmani A.M., Meo A.S., Klonoff D.C., Hoang T.D., Biological and epidemiological trends in the prevalence and mortality due to outbreaks of novel coronavirus COVID-19, J. King. Saud. Univ. Sci, 32, pp. 2495-2499, (2020)
  11. Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y., Et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study, Lancet, 395, pp. 507-513, (2020)
  12. Chan J.F., Yuan S., Kok K.H., To K.K., Chu H., Yang J., Xing F., Liu J., Yip C.C., Poon R.W., Et al., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster, Lancet, 395, pp. 514-523, (2020)
  13. Xu X., Chen P., Wang J., Feng J., Zhou H., Li X., Zhong W., Hao P., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission, Sci. China Life Sci, 63, pp. 457-460, (2020)
  14. Tamara A., Tahapary D.L., Obesity as a predictor for a poor prognosis of COVID-19: A systematic review, Diabetes Metab. Syndr, 14, pp. 655-659, (2020)
  15. Welch C., Greig C., Masud T., Wilson D., Jackson T.A., COVID-19 and Acute Sarcopenia, Aging Dis, 11, pp. 1345-1351, (2020)
  16. Chen Y., Klein S.L., Garibaldi B.T., Li H., Wu C., Osevala N.M., Li T., Margolick J.B., Pawelec G., Leng S.X., Aging in COVID-19: Vulnerability, immunity and intervention, Ageing Res. Rev, 65, (2021)
  17. Kortebein P., Ferrando A., Lombeida J., Wolfe R., Evans W.J., Effect of 10 days of bed rest on skeletal muscle in healthy older adults, JAMA, 297, pp. 1772-1774, (2007)
  18. Marino D.M., Marrara K.T., Arcuri J.F., Candolo C., Jamami M., Pires Di Lorenzo V.A., Determination of exacerbation predictors in patients with COPD in physical therapy—A longitudinal study, Braz. J. Phys. Ther, 18, pp. 127-136, (2014)
  19. Rawal G., Yadav S., Kumar R., Post-intensive Care Syndrome: An Overview, J. Transl. Int. Med, 5, pp. 90-92, (2017)
  20. Niu S., Tian S., Lou J., Kang X., Zhang L., Lian H., Zhang J., Clinical characteristics of older patients infected with COVID-19: A descriptive study, Arch. Gerontol. Geriatr, 89, (2020)
  21. Ferrando C., Suarez-Sipmann F., Mellado-Artigas R., Hernandez M., Gea A., Arruti E., Aldecoa C., Martinez-Palli G., Martinez-Gonzalez M.A., Slutsky A.S., Et al., Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS, Intensive Care Med, 46, pp. 2200-2211, (2020)
  22. Gardashkhani S., Ajri-Khameslou M., Heidarzadeh M., Rajaei Sedigh S., Post-Intensive Care Syndrome in COVID-19 Patients Discharged from the Intensive Care Unit, J. Hosp. Palliat. Nurs, 23, pp. 530-538, (2021)
  23. Peghin M., Palese A., Venturini M., De Martino M., Gerussi V., Graziano E., Bontempo G., Marrella F., Tommasini A., Fabris M., Et al., Post-COVID-19 symptoms 6 months after acute infection among hospitalized and non-hospitalized patients, Clin. Microbiol. Infect, 27, pp. 1507-1513, (2021)
  24. Simpson R., Robinson L., Rehabilitation following critical illness in people with COVID-19 infection, Am. J. Phys. Med. Rehabil, 99, pp. 470-474, (2020)
  25. Silva E.C.G., Godoy C.G., Gambeta A.C., Schmitt A.C.B., Fu C., Tanaka C., Carvalho C.R.F., Toufen Junior C., Carvalho C., Pompeu J.E., Ambulation Capacity, Age, Immunosuppression, And Mechanical Ventilation Are Risk Factors Of In-Hospital Death In Severe COVID-19: A Cohort Study, Clinics, 77, (2022)
  26. Kamdar B.B., Huang M., Dinglas V.D., Colantuoni E., von Wachter T.M., Hopkins R.O., Needham D.M., Joblessness and lost earnings after acute respiratory distress syndrome in a 1-year national multicenter study, Am. J. Respir. Crit. Care Med, 196, pp. 1012-1020, (2017)
  27. Rydingsward J.E., Horkan C.M., Mogensen K.M., Quraishi S.A., Amrein K., Christopher K.B., Functional status in ICU survivors and out of hospital outcomes: A cohort study, Crit. Care Med, 44, pp. 869-879, (2016)
  28. Vrettou C.S., Mantziou V., Vassiliou A.G., Orfanos S.E., Kotanidou A., Dimopoulou I., Post-Intensive Care Syndrome in Survivors from Critical Illness including COVID-19 Patients: A Narrative Review, Life, 12, (2022)
  29. Berlinska A., Swiatkowska-Stodulska R., Sworczak K., Old Problem, New Concerns: Hypercortisolemia in the Time of COVID-19, Front. Endocrinol, 5, (2021)
  30. Estatuto do Idoso/Ministério da Saúde, (2009)
  31. Mehrholz J., Wagner K., Rutte K., Meissner D., Pohl M., Predictive validity and responsiveness of the functional ambulation category in hemiparetic patients after stroke, Arch. Phys. Med. Rehabil, 88, pp. 1314-1319, (2007)
  32. Lamontagne F., Agarwal A., Rochwerg B., Siemieniuk R.A., Agoritsas T., Askie L., Lytvyn L., Agarwal A., Leo Y.-S., Macdonald H., Et al., A living WHO guideline on drugs for COVID-19, BMJ, 370, (2020)
  33. Pal C., Fu C., Carvalho C.R.R., Auler Junior J.O.C., Yamauchi L.Y., Association of the mobility level of critically ill adult patients with the success of extubation: Protocol for a cohort study, BMJ Open, 11, (2021)
  34. Kemp H.I., Corner E., Colvin L.A., Chronic Pain after COVID-19: Implications for Rehabilitation, Br. J. Anaesth, 125, pp. 436-440, (2020)
  35. Ranzani O.T., Bastos L.S.L., Gelli J.G.M., Marchesi J.F., Baiao F., Hamacher S., Bozza F.A., Characterisation of the first 250,000 hospital admissions for COVID-19 in Brazil: A retrospective analysis of nationwide data, Lancet Respir. Med, 9, pp. 407-418, (2021)
  36. Tavares G.S., Oliveira C.C., Mendes L.P.S., Velloso M., Muscle strength and mobility of individuals with COVID-19 compared with non-COVID-19 in intensive care, Heart Lung, 62, pp. 233-239, (2023)
  37. Meftahi G.H., Jangravi Z., Sahraei H., Bahari Z., The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: The contribution of “inflame-aging, Inflamm. Res, 69, pp. 825-839, (2020)
  38. Martin J., Padierna A., Anton-Ladislao A., Moro I., Quintana J.M., Predictors of mortality during hospitalization and 3 months after discharge in elderly people with and without dementia, Aging Ment. Health, 23, pp. 1057-1065, (2019)
  39. Schujmann D.S., Lunardi A.C., Peso C.N., Pompeu J.E., Annoni R., Miura M.C., de Censo C.M., Taniguchi L.N.T., de Moraes Regenga M., de Campos E.C., Et al., Functional Recovery Groups in Critically Ill COVID-19 Patients and Their Associated Factors: From ICU to Hospital Discharge*, Crit. Care Med, 50, pp. 1799-1808, (2022)
  40. Moura E.C., Silva EN da Sanchez M.N., Cavalcante F.V., Oliveira LG de Oliveira A., Frio G.S., Santos L.M.P., Timely Availability of Public Data for Health Management: COVID-19 Wave’s Analysis
  41. Perrotta F., Corbi G., Mazzeo G., Boccia M., Aronne L., D'agnano V., Komici K., Mazzarella G., Parrella R., Bianco A., COVID-19 and the elderly: Insights into pathogenesis and clinical decision-making, Aging Clin. Exp. Res, 32, pp. 1599-1608, (2020)
  42. Stam H.J., Stucki G., Bickenbach J., COVID-19 and Post Intensive Care Syndrome: A Call for Action, J. Rehabil. Med, 52, (2020)
  43. Silva Andrade B., Siqueira S., de Assis Soares W.R., de Souza Rangel F., Santos N.O., Dos Santos Freitas A., Ribeiro da Silveira P., Tiwari S., Alzahrani K.J., Goes-Neto A., Et al., Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms, Viruses, 13, (2021)
  44. Jaffri A., Jaffri U.A., Post-Intensive care syndrome and COVID-19: Crisis after a crisis?, Heart Lung, 49, pp. 883-884, (2020)
  45. Freitas A.R., Napimoga M., Donalisio M.R., Avaliando a gravidade do COVID-19, Epidemiol. Saúde, 29, (2020)
  46. Ochiai G.S., Godoy C.G., Silva E.C.G., Oliveira D.B., Silva E.M., Viana B.O.C., Silva S.M.D., Souza R.O.B., Campos C.M., Schmitt A.C.B., Et al., Functional impact on adults and older people after hospitalization by COVID-19, Physiother. Res. Int, 28, (2023)
  47. Godoy C.G., Silva E.C.G., Oliveira D.B., Silva E.M., Campos C.M., Gambeta A.C., Carvalho C.R.F., Fu C., Schmitt A.C.B., Tanaka C., Et al., Protocol for Functional Assessment of Adults and Older Adults After Hospitalization by COVID-19, Clinics, 76, (2021)
  48. Alonso A.C., Silva-Santos P.R., Quintana M.S.L., Silva V.C.D., Brech G.C., Barbosa L.G., Pompeu J.E., Silva E., Silva E.M.D., Godoy C.G.D., Et al., Physical and Pulmonary Capacities of Individuals with Severe Coronavirus Disease After Hospital Discharge: A Preliminary Cross-Sectional Study Based On Cluster Analysis, Clinics, 76, (2021)