Sex-Dependent Metabolic Alterations of Rat Liver After 12-Week Exposition to Haloperidol or Clozapine

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorWILMSDORFF, M. von
dc.contributor.authorBOUVIER, M. -L.
dc.contributor.authorHENNING, U.
dc.contributor.authorSCHMITT, A.
dc.contributor.authorSCHNEIDER-AXMANN, T.
dc.contributor.authorGAEBEL, W.
dc.date.accessioned2015-02-06T19:59:37Z
dc.date.available2015-02-06T19:59:37Z
dc.date.issued2014
dc.description.abstractAntipsychotic drugs are known to have sex-dependent effects on metabolic homeostasis. Liver plays a crucial role in drug degradation as well as in glucose and lipid metabolism. The present study examines the influence of clozapine and haloperidol on metabolic liver parameters. Over 12 weeks, male and female Sprague-Dawley rats were fed ground pellets containing clozapine or haloperidol. Liver mass was weighed and liver index calculated. Liver transaminases (ALAT, ALP), malondialdehyde, glucose, triglycerides, total cholesterol, HDL-cholesterol, and glycogen were determined. Finally, SREBP-1 and SREBP-2 as well as neutral fat deposits were examined. In male rats fed with clozapine, we found increased liver mass correlated with an increased liver index, high triglyceride levels, a high ratio of SREBP-1, and an elevated neutral fat distribution. Male and female haloperidol treated rats showed decreased liver mass and increased neutral fat deposition. Malondialdehyde was increased in all rats receiving antipsychotic medication indicating elevated oxidative stress. In both male and female clozapine treated rats, we found glycogen depletion related to decreased glucose levels in females. While liver transaminases were unchanged in the clozapine group, ALAT was elevated after haloperidol treatment in both sexes. Chronic clozapine intake exerts sex-dependent effects on hepatic metabolism. Although haloperidol has been shown to change fewer metabolic parameters, it causes oxidative stress and neutral fat deposits in liver tissue in both sexes.
dc.description.indexMEDLINE
dc.identifier.citationHORMONE AND METABOLIC RESEARCH, v.46, n.11, p.782-788, 2014
dc.identifier.doi10.1055/s-0034-1384605
dc.identifier.eissn1439-4286
dc.identifier.issn0018-5043
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8794
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KG
dc.relation.ispartofHormone and Metabolic Research
dc.rightsrestrictedAccess
dc.rights.holderCopyright GEORG THIEME VERLAG KG
dc.subjectglucose
dc.subjectglycogen
dc.subjectlipid metabolism
dc.subjectoxidative stress
dc.subject.otherantipsychotic-drugs
dc.subject.otherlipid-accumulation
dc.subject.otherpossible mechanism
dc.subject.otherenergy-metabolism
dc.subject.otheroxidative stress
dc.subject.otherexpression
dc.subject.otherweight
dc.subject.othercells
dc.subject.othersrebp
dc.subject.otherschizophrenia
dc.subject.wosEndocrinology & Metabolism
dc.titleSex-Dependent Metabolic Alterations of Rat Liver After 12-Week Exposition to Haloperidol or Clozapine
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalWILMSDORFF, M. von:Univ Dusseldorf, Fac Med, Dept Psychiat & Psychotherapy, Dusseldorf, Germany
hcfmusp.author.externalBOUVIER, M. -L.:Univ Dusseldorf, Fac Med, Dept Psychiat & Psychotherapy, Dusseldorf, Germany
hcfmusp.author.externalHENNING, U.:Univ Dusseldorf, Fac Med, Dept Psychiat & Psychotherapy, Dusseldorf, Germany
hcfmusp.author.externalSCHNEIDER-AXMANN, T.:Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany
hcfmusp.author.externalGAEBEL, W.:Univ Dusseldorf, Fac Med, Dept Psychiat & Psychotherapy, Dusseldorf, Germany
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcANDREA SCHMITT
hcfmusp.description.beginpage782
hcfmusp.description.endpage788
hcfmusp.description.issue11
hcfmusp.description.volume46
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84931039745
hcfmusp.origem.wosWOS:000343583200006
hcfmusp.publisher.citySTUTTGART
hcfmusp.publisher.countryGERMANY
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