Physical Exercise Improves Peripheral BDNF Levels and Cognitive Functions in Mild Cognitive Impairment Elderly with Different BDNF Val66Met Genotypes
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Citações na Scopus
114
Tipo de produção
article
Data de publicação
2015
Título da Revista
ISSN da Revista
Título do Volume
Editora
IOS PRESS
Autores
NASCIMENTO, Carla Manuela Crispim
PEREIRA, Jessica Rodrigues
ANDRADE, Larissa Pires de
GARUFFI, Marcelo
AYAN, Carlos
COMINETTI, Marcia Regina
Citação
JOURNAL OF ALZHEIMERS DISEASE, v.43, n.1, p.81-91, 2015
Resumo
The benefits of physical exercise on improvements in brain-derived neurotrophic factor (BDNF) levels and cognitive functioning have been reported in the literature. However, the variability of individual responses may be linked to genetic differences. BDNF is considered one of the most plausible factors involved in the cognitive benefits associated with physical activity practice. A single nucleotide polymorphism localized in the gene that codes BDNF results in a missense mutation that promotes an amino acid substitution (Val66Met) in the protein. This process has been associated with decreased levels of BDNF secretion, with corresponding impairments in specific cognitive functions. Therefore, the objective of this study was to analyze the effects of a multimodal physical exercise program on peripheral BDNF levels and cognitive functions in elderly individuals with mild cognitive impairment (MCI). The participants were genotyped for the BDNF Val66Met polymorphism. Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Forty-five participants were assigned to the control and trained groups. The trained group participated in a multimodal physical training for a 16-week period. The results showed a significant between-subjects interaction (p < 0.05), which indicates the beneficial contribution of training on cognitive functions independent of the BDNF genotype. However, only participants with BDNF-Met genotypes exhibited significant improvements in peripheral BDNF levels. The BDNF genotype appears to modulate the effects of physical exercise on BDNF secretion, but it does not influence cognition. This is the first study that evaluated the influence of a BDNF polymorphism on physical activity and cognition performance in elderly MCI individuals.
Palavras-chave
Brain-derived neurotrophic factor, cognition, genetic polymorphism, mild cognitive impairment, physical exercises
Referências
- ACSM ACoSM, 2006, AM COLL SPORTS MED G
- Almeida OP, 1999, ARQ NEURO-PSIQUIAT, V57, P421, DOI 10.1590/S0004-282X1999000300013
- Almeida OP, 1999, INT J GERIATR PSYCH, V14, P858, DOI 10.1002/(SICI)1099-1166(199910)14:10<858::AID-GPS35>3.0.CO;2-8
- Alsina B, 2001, NAT NEUROSCI, V4, P1093, DOI 10.1038/nn735
- Amieva H, 2004, DEMENT GERIATR COGN, V18, P87, DOI 10.1159/000077815
- Angevaren M, 2008, COCHRANE DATABASE SY
- Barde Y A, 1994, Prog Clin Biol Res, V390, P45
- Berchtold NC, 2010, NEUROSCIENCE, V167, P588, DOI 10.1016/j.neuroscience.2010.02.050
- Buchman AS, 2012, ARCH INTERN MED, V172, P444, DOI 10.1001/archinternmed.2011.1477
- Clark BA, 1989, AM J HLTH ED, V60, P66
- Colcombe S, 2003, PSYCHOL SCI, V14, P125, DOI 10.1111/1467-9280.t01-1-01430
- Colcombe SJ, 2003, J GERONTOL A-BIOL, V58, P176
- Cotman CW, 2002, TRENDS NEUROSCI, V25, P295, DOI 10.1016/S0166-2236(02)02143-4
- Cotman CW, 2002, EXERC SPORT SCI REV, V30, P75, DOI 10.1097/00003677-200204000-00006
- Deslandes A, 2009, NEUROPSYCHOBIOLOGY, V59, P191, DOI 10.1159/000223730
- Dias IHK, 2014, J ALZHEIMERS DIS, V40, P399, DOI 10.3233/JAD-131964
- Dik MG, 2003, J CLIN EXP NEUROPSYC, V25, P643, DOI 10.1076/jcen.25.5.643.14583
- Egan MF, 2003, CELL, V112, P257, DOI 10.1016/S0092-8674(03)00035-7
- Erickson KI, 2008, FRONT HUM NEUROSCI, V2, P11
- Erickson KI, 2009, BRIT J SPORT MED, V43, P22, DOI 10.1136/bjsm.2008.052498
- Erickson KI, 2012, NEUROSCIENTIST, V18, P82, DOI 10.1177/1073858410397054
- Erickson KI, 2013, PSYCHOL SCI, V24, P1770, DOI 10.1177/0956797613480367
- Faul F, 2007, BEHAV RES METHODS, V39, P175, DOI 10.3758/BRM.41.4.1149
- Forlenza OV, 2010, WORLD J BIOL PSYCHIA, V11, P774, DOI 10.3109/15622971003797241
- Frisardi V, 2010, AGEING RES REV, V9, P399, DOI 10.1016/j.arr.2010.04.007
- Hopkins ME, 2012, NEUROSCIENCE, V215, P59
- HUGHES CP, 1982, BRIT J PSYCHIAT, V140, P566, DOI 10.1192/bjp.140.6.566
- Kim JM, 2011, NEUROBIOL AGING, V32, P551
- Knaepen K, 2010, SPORTS MED, V40, P765, DOI 10.2165/11534530-000000000-00000
- Kojda G, 2005, CARDIOVASC RES, V67, P187, DOI 10.1016/j.cardiores.2005.04.032
- Kramer AF, 2007, TRENDS COGN SCI, V11, P342, DOI 10.1016/j.tics.2007.06.009
- Kramer AF, 2003, J MOL NEUROSCI, V20, P213, DOI 10.1385/JMN:20:3:213
- Lang UE, 2009, MOL PSYCHIATR, V14, P120, DOI 10.1038/mp.2008.80
- Larson EB, 2006, ANN INTERN MED, V144, P73
- Li R, 2014, FRONT AGING NEUROSCI, V6, DOI 10.3389/fnagi.2014.00039
- Lim YY, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0086498
- Lu B, 2003, LEARN MEMORY, V10, P86, DOI 10.1101/lm.54603
- Memoria CM, 2013, INT J GERIATR PSYCH, V28, P34, DOI 10.1002/gps.3787
- Nasreddine ZS, 2005, J AM GERIATR SOC, V53, P695, DOI 10.1111/j.1532-5415.2005.53221.x
- Petersen RC, 2004, J INTERN MED, V256, P183, DOI 10.1111/j.1365-2796.2004.01388.x
- Petersen RC, 2008, CNS SPECTRUMS, V13, P45
- Pfeffer RI, 1982, GERONTOLOGY, V37, P323
- Pruunsild P, 2007, GENOMICS, V90, P397, DOI 10.1016/j.ygeno.2007.05.004
- Suzuki T, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061483
- Tanaka H, 2001, J AM COLL CARDIOL, V37, P153, DOI 10.1016/S0735-1097(00)01054-8
- Taniguchi Y, 2014, J GERONTOL A-BIOL, V69, P1276, DOI 10.1093/gerona/glt286
- Taylor WD, 2007, AM J GERIAT PSYCHIAT, V15, P850, DOI 10.1097/JGP.0b013e318050c9d5
- Teixeira CVL, 2012, ARCH GERONTOL GERIAT, V54, P175, DOI 10.1016/j.archger.2011.02.014
- Teri L, 2003, JAMA-J AM MED ASSOC, V290, P2015, DOI 10.1001/jama.290.15.2015
- van Uffelen JGZ, 2008, CLIN J SPORT MED, V18, P486, DOI 10.1097/JSM.0b013e3181845f0b
- van Uffelen JGZ, 2009, J AGING PHYS ACTIV, V17, P398
- Vaughan S, 2012, BMC GERIATR, V12, DOI 10.1186/1471-2318-12-60
- Verghese J, 2003, NEW ENGL J MED, V348, P2508, DOI 10.1056/NEJMoa022252
- VOORRIPS LE, 1991, MED SCI SPORT EXER, V23, P974, DOI 10.1249/00005768-199108000-00015
- Wang HX, 2013, J GERONTOL A-BIOL, V68, P205, DOI 10.1093/gerona/gls153
- Warburton DER, 2006, CAN MED ASSOC J, V174, P801, DOI 10.1503/cmaj.051351
- Winblad B, 2004, J INTERN MED, V256, P240, DOI 10.1111/j.1365-2796.2004.01380.x
- Zago AS, 2003, REV BRASILEIRA CIENC, V11, P77
- Zoladz JA, 2010, J PHYSIOL PHARMACOL, V61, P533