Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFORLENZA, Orestes Vicente
dc.contributor.authorDINIZ, Breno Satler
dc.contributor.authorTEIXEIRA, Antonio Lucio
dc.contributor.authorRADANOVIC, Marcia
dc.contributor.authorTALIB, Leda Leme
dc.contributor.authorROCHA, Natalia Pessoa
dc.contributor.authorGATTAZ, Wagner Farid
dc.date.accessioned2015-10-26T16:31:59Z
dc.date.available2015-10-26T16:31:59Z
dc.date.issued2015
dc.description.abstractThere is little information on the dynamics of BDNF in the CSF in the continuum between healthy aging, MCI and AD. We included 128 older adults (77 with amnestic MCI, 26 with AD and 25 healthy controls). CSF BDNF level was measured by ELISA assay, and AD biomarkers (A beta(42), T-Tau and P-Tau(181)) were measured using a Luminex xMAP assay. CSF BDNF levels were significantly reduced in AD subjects compared to MCI and healthy controls (p = 0.009). Logistic regression models showed that lower CSF BDNF levels (p = 0.008), lower CSF A beta(42) (p = 0.005) and lower MMSE scores (p = 0.007) are significantly associated with progression from MCI to AD. The present study adds strong evidence of the involvement of BDNF in the pathophysiology of neurodegenerative changes in AD. Interventions aiming to restore central neurotrophic support may represent future therapeutic targets to prevent or delay the progression from MCI to AD.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [472138/2013-8, 466623/2014-3]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [02/12633-7]
dc.description.sponsorshipAssociacao Beneficente Alzira Denise Hertzog da Silva (ABADHS)
dc.identifier.citationNEUROMOLECULAR MEDICINE, v.17, n.3, p.326-332, 2015
dc.identifier.doi10.1007/s12017-015-8361-y
dc.identifier.eissn1559-1174
dc.identifier.issn1535-1084
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/11789
dc.language.isoeng
dc.publisherHUMANA PRESS INC
dc.relation.ispartofNeuromolecular Medicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright HUMANA PRESS INC
dc.subjectAlzheimer's disease
dc.subjectMild cognitive impairment
dc.subjectBrain-derived neurotrophic factor
dc.subjectCerebrospinal fluid
dc.subjectBiomarkers
dc.subjectPathophysiology
dc.subject.otherlate-life depression
dc.subject.othermajor depression
dc.subject.otherserum bdnf
dc.subject.otherval66met polymorphism
dc.subject.othercontrolled-trial
dc.subject.othermarkers
dc.subject.othercsf
dc.subject.wosNeurosciences
dc.titleLower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer's Disease
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalDINIZ, Breno Satler:Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Neurosci LIM 27, BR-05403010 Sao Paulo, SP, Brazil; Univ Fed Minas Gerais, Fac Med, Dept Mental Hlth, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais, Fac Med, Natl Inst Sci & Technol Mol Med INCT MM, Belo Horizonte, MG, Brazil
hcfmusp.author.externalTEIXEIRA, Antonio Lucio:Univ Fed Minas Gerais, Fac Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil
hcfmusp.author.externalROCHA, Natalia Pessoa:Univ Fed Minas Gerais, Fac Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil
hcfmusp.citation.scopus55
hcfmusp.contributor.author-fmusphcORESTES VICENTE FORLENZA
hcfmusp.contributor.author-fmusphcMARCIA RADANOVIC
hcfmusp.contributor.author-fmusphcLEDA LEME TALIB
hcfmusp.contributor.author-fmusphcWAGNER FARID GATTAZ
hcfmusp.description.beginpage326
hcfmusp.description.endpage332
hcfmusp.description.issue3
hcfmusp.description.volume17
hcfmusp.origemWOS
hcfmusp.origem.pubmed26138246
hcfmusp.origem.scopus2-s2.0-84938971568
hcfmusp.origem.wosWOS:000359552200009
hcfmusp.publisher.cityTOTOWA
hcfmusp.publisher.countryUSA
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