Glycogen Synthase Kinase-3 beta: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMUNKHOLM, Klaus
dc.contributor.authorLENSKJOLD, Toke
dc.contributor.authorJACOBY, Anne Sophie
dc.contributor.authorMISKOWIAK, Kamilla Woznica
dc.contributor.authorVINBERG, Maj
dc.contributor.authorJOAQUIM, Helena Giroud Passarelli
dc.contributor.authorTALIB, Leda Leme
dc.contributor.authorGATTAZ, Wagner Farid
dc.contributor.authorKESSING, Lars Vedel
dc.date.accessioned2016-07-18T12:22:38Z
dc.date.available2016-07-18T12:22:38Z
dc.date.issued2016
dc.description.abstractEvidence indicates a role for glycogen synthase kinase-3 beta (GSK-3 beta) in the pathophysiology of mood disorders and in cognitive disturbances; however, the natural variation in GSK-3 beta activity over time is unknown. We aimed to investigate GSK-3 beta activity over time and its possible correlation with emotional lability, subjective mood fluctuations and cognitive function in healthy individuals. Thirty-seven healthy subjects were evaluated with neuropsychological tests and blood samples at baseline and 12-week follow-up. Total GSK-3 beta and serine-9-phosphorylated GSK-3 beta in peripheral blood mononuclear cells were quantitated using enzyme immunometric assays. The activity of GSK-3 beta (serine-9-phosphorylated GSK-3 beta/total GSK-3 beta) was lower at baseline compared with follow-up. No significant mean change over time was observed in levels of total GSK-3 beta and serine-9-phosphorylated GSK-3 beta. Exploratory analysis revealed lower activity of GSK-3 beta in spring and summer compared with the fall season. No correlation was observed between GSK-3 beta activity and emotional lability, subjective mood fluctuations or cognitive function. The results suggest that intra- and interindividual variation in GSK-3 beta activity over time could contribute to the heterogeneity of findings in clinical studies. The stability of GSK-3 beta activity and the role of potential moderators of GSK-3 beta activity warrant further investigation. Clinical studies of GSK-3 beta should consider including repeated measures of both cases and healthy individuals. (C) 2016 S. Karger AG, Basel
dc.description.indexMEDLINE
dc.description.sponsorshipLundbeck Foundation
dc.identifier.citationNEUROPSYCHOBIOLOGY, v.73, n.2, p.108-115, 2016
dc.identifier.doi10.1159/000444489
dc.identifier.eissn1423-0224
dc.identifier.issn0302-282X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14365
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofNeuropsychobiology
dc.rightsrestrictedAccess
dc.rights.holderCopyright KARGER
dc.subjectBipolar disorder
dc.subjectPeripheral blood
dc.subjectBiomarker
dc.subject.otherbipolar disorder patients
dc.subject.otheralzheimers-disease
dc.subject.otherelevated levels
dc.subject.otherprefrontal cortex
dc.subject.otherlithium treatment
dc.subject.otherarachidonic-acid
dc.subject.othergene-expression
dc.subject.otherprotein-levels
dc.subject.otherrating-scale
dc.subject.otherkinase-b
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.subject.wosPsychology
dc.titleGlycogen Synthase Kinase-3 beta: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryDinamarca
hcfmusp.affiliation.countryisodk
hcfmusp.author.externalMUNKHOLM, Klaus:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark
hcfmusp.author.externalLENSKJOLD, Toke:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark
hcfmusp.author.externalJACOBY, Anne Sophie:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark
hcfmusp.author.externalMISKOWIAK, Kamilla Woznica:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark
hcfmusp.author.externalVINBERG, Maj:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark
hcfmusp.author.externalJOAQUIM, Helena Giroud Passarelli:Univ Sao Paulo, Fac Med, Neurosci Lab, Dept & Inst Psychiat, Sao Paulo, Brazil
hcfmusp.author.externalKESSING, Lars Vedel:Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Dept O, DK-2100 Copenhagen, Denmark; Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcLEDA LEME TALIB
hcfmusp.contributor.author-fmusphcWAGNER FARID GATTAZ
hcfmusp.description.beginpage108
hcfmusp.description.endpage115
hcfmusp.description.issue2
hcfmusp.description.volume73
hcfmusp.origemWOS
hcfmusp.origem.pubmed27003416
hcfmusp.origem.scopus2-s2.0-84961393803
hcfmusp.origem.wosWOS:000375025200005
hcfmusp.publisher.cityBASEL
hcfmusp.publisher.countrySWITZERLAND
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