Clinical implication of 14-3-3 epsilon expression in gastric cancer

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art_CHAMMAS_Clinical_implication_of_14_3_3_epsilon_expression_2012.PDF (863.46 KB)
Citações na Scopus
36
Tipo de produção
article
Data de publicação
2012
Editora
BAISHIDENG PUBL GRP CO LTD
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
LEAL, Mariana Ferreira
CALCAGNO, Danielle Queiroz
DEMACHKI, Samia
ASSUMPCAO, Paulo Pimentel
BURBANO, Rommel Rodriguez
SMITH, Marilia de Arruda Cardoso
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
WORLD JOURNAL OF GASTROENTEROLOGY, v.18, n.13, p.1531-1537, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
AIM: To evaluate for the first time the protein and mRNA expression of 14-3-3 epsilon in gastric carcinogenesis. METHODS: 14-3-3 epsilon protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples. RESULTS: Authors observed a significant reduction of 14-3-3 epsilon protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue, Reduced levels of 14-3-3 epsilon were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3 epsilon may have a role in gastric carcinogenesis process. CONCLUSION: Our results reveal that the reduced 14-3-3 epsilon expression in GC and investigation of 14-3-3 epsilon interaction partners may help to elucidate the carcinogenesis process.
Palavras-chave
Gastric cancer, 14-3-3 epsilon, YWHAE, Gene expression
URI
https://observatorio.fm.usp.br/handle/OPI/1125
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - LIM/24