Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

Imagem de Miniatura
Arquivos
art_MARTINS_Ki67_Expression_in_CRC_Lymph_Node_Metastasis_Does_2015.PDF (4.08 MB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HINDAWI PUBLISHING CORPORATION
Autores
MARTINS, Sandra F.
AMORIM, Ricardo
MOTA, Silvia Coelho
COSTA, Luis
PARDAL, Fernando
RODRIGUES, Mesquita
Citação
BIOMED RESEARCH INTERNATIONAL, article ID 131685, 13p, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Colorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/12573
Referências
  1. Le Voyer TE, 2003, J CLIN ONCOL, V21, P2912, DOI 10.1200/JCO.2003.05.062
  2. Saad RS, 2004, MODERN PATHOL, V17, P197, DOI 10.1038/modpathol.3800034
  3. Freitas D, 2002, HEPATO-GASTROENTEROL, V49, P1269
  4. Ferlay J, 2013, EUR J CANCER, V49, P1374, DOI 10.1016/j.ejca.2012.12.027
  5. Malvezzi M, 2013, ANN ONCOL, V24, P792, DOI 10.1093/annonc/mdt010
  6. Alexander Dominik D., 2007, Cancer Biomarkers, V3, P301
  7. Cabibi D, 2006, ANTICANCER RES, V26, P4357
  8. Scholzen T, 2000, J CELL PHYSIOL, V182, P311, DOI 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9
  9. de Menezes Hunaldo Lima, 2010, Arquivos de Gastroenterologia, V47, P141, DOI 10.1590/S0004-28032010000200005
  10. Tredan O, 2007, J NATL CANCER I, V99, P1441, DOI 10.1093/jnci/djm135
  11. Bilchik AJ, 2006, ARCH SURG-CHICAGO, V141, P527, DOI 10.1001/archsurg.141.6.527
  12. Pinto CG, 2010, EUR J HEALTH ECON, V10, P65, DOI 10.1007/s10198-009-0187-9
  13. Park D, 2007, VIRCHOWS ARCH, V451, P11, DOI 10.1007/s00428-007-0435-2
  14. GERDES J, 1983, INT J CANCER, V31, P13, DOI 10.1002/ijc.2910310104
  15. Brenner H, 2008, BRIT J CANCER, V99, P532, DOI 10.1038/sj.bjc.6604488
  16. Oshima CTF, 2005, NEOPLASMA, V52, P420
  17. Gurzu S, 2008, ROM J MORPHOL EMBRYO, V49, P149
  18. KUBOTA Y, 1992, CANCER, V70, P2602, DOI 10.1002/1097-0142(19921201)70:11<2602::AID-CNCR2820701106>3.0.CO;2-W
  19. Zavoral M, 2009, WORLD J GASTROENTERO, V15, P5907, DOI 10.3748/wjg.15.5907
  20. Cascinu S, 2003, ANN ONCOL, V14, P25, DOI 10.1093/annonc/mdg725
  21. Martins SF, 2013, CANCER GENOM PROTEOM, V10, P55
  22. Evans C, 2006, BRIT J CANCER, V94, P1412, DOI 10.1038/sj.bjc.6603104
  23. Valera V, 2005, BRIT J SURG, V92, P1002, DOI 10.1002/bjs.4858
  24. Bai XZ, 1999, INT J ONCOL, V14, P785
  25. Bosetti C, 2011, INT J CANCER, V129, P180, DOI 10.1002/ijc.25653
  26. Pinheiro C, 2008, VIRCHOWS ARCH, V452, P139, DOI 10.1007/s00428-007-0558-5
  27. Allegra CJ, 2003, J CLIN ONCOL, V21, P241, DOI 10.1200/JCO.2003.05.044
  28. Toru S, 2012, W INDIAN MED J, V61, P10
  29. Buxant F, 2002, BREAST CANCER RES TR, V75, P1, DOI 10.1023/A:1016504129183
  30. Ries LAG, 2000, CANCER, V88, P2398, DOI 10.1002/(SICI)1097-0142(20000515)88:10<2398::AID-CNCR26>3.0.CO;2-I
  31. Tawfik K, 2013, HUM PATHOL, V44, P39, DOI 10.1016/j.humpath.2012.05.007
  32. Yamauchi H, 2011, INT SURG, V96, P352
  33. Des Guetz G, 2006, BRIT J CANCER, V94, P1823, DOI 10.1038/sj.bjc.6603176
  34. Dziegiel P, 2003, HISTOL HISTOPATHOL, V18, P401
  35. Jansson A, 1997, APMIS, V105, P730
  36. Barozzi C, 2002, CANCER, V94, P647, DOI 10.1002/cncr.10278
  37. BROWN DC, 1990, HISTOPATHOLOGY, V17, P489, DOI 10.1111/j.1365-2559.1990.tb00788.x
  38. Calvo H. J., 2000, CIR ESPAN, V68, P577
  39. Gao W. X., 2007, XIAN DAI YU FANG YI, V2, P225
  40. Ghita C, 2012, ROM J MORPHOL EMBRYO, V53, P549
  41. Greene FL, 2002, AJCC CANC STAGING MA
  42. Guzinska-Ustymowicz K, 2008, ANTICANCER RES, V28, P451
  43. Harvey J, 2015, PATHOLOGY, V47, P13, DOI 10.1097/PAT.0000000000000192
  44. Hashimoto Y, 2006, BMC CANCER, V6, DOI 10.1186/1471-2407-6-241
  45. Hosaka M., 1998, PATHOLOGY INT, V48, P41
  46. Jo M. J., 2015, WORLD J GASTROENTERO, V21, P667
  47. Lin Miao-Xia, 2008, Ai Zheng, V27, P1321
  48. Longo D. L., 2012, HARRISONS PRINCIPLES
  49. Martins SF, 2011, WJC, V10, P272
  50. Micev M, 2004, Acta Chir Iugosl, V51, P99
  51. Nabi Uzma, 2008, J Ayub Med Coll Abbottabad, V20, P44
  52. Nussrat Faris Lutfi, 2011, Oman Med J, V26, P229, DOI 10.5001/omj.2011.57
  53. Saleh H A, 1999, Pathol Oncol Res, V5, P273, DOI 10.1053/paor.1999.0231
  54. Svagzdys S, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-95
  55. Zafar SY, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-345

Coleções
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - ODS/03