Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
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Citações na Scopus
169
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
DUITS, Flora H.
MARTINEZ-LAGE, Pablo
PAQUET, Claire
ENGELBORGHS, Sebastiaan
LLEO, Alberto
HAUSNER, Lucrezia
MOLINUEVO, Jose L.
STOMRUD, Erik
FAROTTI, Lucia
RAMAKERS, Inez H. G. B.
Citação
ALZHEIMERS & DEMENTIA, v.12, n.2, p.154-163, 2016
Resumo
Introduction: Lumbar puncture (LP) is increasingly performed in memory clinics. We investigated patient-acceptance of LP, incidence of and risk factors for post-LP complications in memory clinic populations. Methods: We prospectively enrolled 3868 patients (50% women, age 66 +/- 11 years, mini mental state examination 25 +/- 5) at 23 memory clinics. We used logistic regression analysis using generalized estimated equations to investigate risk factors for post-LP complications, such as typical postlumbar puncture headache (PLPH) and back pain. Results: A total of 1065 patients (31%) reported post-LP complaints; 589 patients (17%) reported back pain, 649 (19%) headache, of which 296 (9%) reported typical PLPH. Only few patients needed medical intervention: 11 (0.3%) received a blood patch, 23 (0.7%) were hospitalized. The most important risk factor for PLPH was medical history of headache. An atraumatic needle and age >65 years were preventive. Gender, rest after LP, or volume of cerebrospinal fluid had no effect. Discussions: The overall risk of complications is relatively low. If risk factors shown in this study are taken into account, LPs can be safely performed in memory clinics.
Palavras-chave
Lumbar puncture, Cognitive disorders, Alzheimer's disease, Memory clinic, Post-LP complications, Post-LP headache, Multicenter study on LP feasibility
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