Temporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil

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art_PIMENTEL_Temporal_Trends_and_Molecular_Epidemiology_of_HIV_Type_2013.PDF (391.06 KB)
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10
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article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
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Autores
PIMENTEL, Victor F.
MORGADO, Mariza G.
BELLO, Gonzalo
GUIMARAES, Mark D. C.
VELOSO, Valdilea G.
GUIMARAES, Monick L.
Citação
AIDS RESEARCH AND HUMAN RETROVIRUSES, v.29, n.12, p.1553-1561, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
HIV-1 molecular epidemiology studies carried out in Rio de Janeiro, Brazil have identified the prevalence of subtypes B, F1 and BF1 recombinants. A high percentage of HIV-1 subtype B isolates in Rio de Janeiro harbor the GWG motif at the V3 tip (B variant) instead of the canonical GPG motif (B variant). To trace the dynamics of the HIV-1 variants over time in different exposure categories in Rio de Janeiro, the HIV-1 proviral DNA from heterosexual men (HET) and men who have sex with men (MSM) from two distinct time periods (1990-1992 and 2008-2010) were extracted, and the env-gp120 region was amplified. Neighbor-joining phylogenetic analysis was performed to determine the viral subtype, and Bayesian analysis was used to trace the HIV-1 transmission networks. A predominance of subtype B was observed in both study periods, independent of the exposure risk category. An increase of non-B subtypes was observed in the HET group, but these subtypes were maintained among the MSM group. The distribution of HIV-1 subtype B signatures in the first and second periods studied were, respectively, HET (GPG) [44.8-51.5%], (GWG) [13.8-33.3%], and (GXG) [41.4-15.2%] and MSM (GPG) [34-50%], (GWG) [55.3-30.6%], and (GXG) [10.7-19.4%]. In the first period, an association between GWG and MSM was verified while a significant reduction of this association was observed during the second period. The phylogenetic tree and the BaTS program detected the clustering of isolates only according to the B signatures but not by exposure risk category. Our findings indicate a stable prevalence of HIV-1 subtypes B and F over time in Rio de Janeiro and further suggest that the B subclade of subtype B was possibly introduced into the MSM group in this area of Brazil.
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https://observatorio.fm.usp.br/handle/OPI/15995
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Artigos e Materiais de Revistas Científicas - FM/MPR
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