Neurohumoral and Endothelial Responses to Heated Water-Based Exercise in Resistant Hypertensive Patients

Imagem de Miniatura
Arquivos
art_CRUZ_Neurohumoral_and_Endothelial_Responses_to_Heated_WaterBased_Exercise_2017.PDF (649.18 KB)
Citações na Scopus
26
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
JAPANESE CIRCULATION SOC
Autores
GRASSI, Guido
Citação
CIRCULATION JOURNAL, v.81, n.3, p.339-345, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The neurohumoral and endothelial responses to the blood pressure (BP) lowering effects of heated water- based exercise (HEx) in resistant hypertension (HT) patients remain undefined. Methods and Results: We investigated these in 44 true resistant HT patients (age 53.3 +/- 0.9 years, mean +/- SEM). They were randomized and allocated to 2 groups, 28 to a HEx training protocol, which consisted of callisthenic exercises and walking in a heated pool for 1 h, three times weekly for 12 weeks and 16 patients to a control group maintaining their habitual activities. Measurements made before and after 12 weeks of HEx included clinic and 24-h BP, plasma levels of nitric oxide, endothelin- 1, aldosterone, renin, norepinephrine and epinephrine, as well as peak V. O2, and endothelial function (reactive hyperemia). After 12 weeks of HEx patients showed a significant decrease in clinic and 24- h systolic and diastolic BPs. Concomitantly, nitric oxide increased significantly (from 25 +/- 8 to 75 +/- 24 mu mol/ L, P < 0.01), while endothelin-1 (from 41 +/- 5 to 26 +/- 3 pg/ mL), renin (from 35 +/- 4 to 3.4 +/- 1 ng/mL/h), and norepinephrine (from 720 +/- 54 to 306 +/- 35 pg/ mL) decreased significantly (P < 0.01). Plasma aldosterone also tended to decrease, although not significantly (from 101 +/- 9 to 76 +/- 4 pg/ mL, P=NS). Peak VO2 increased significantly after HEx (P < 0.01), while endothelial function was unchanged. No significant change was detected in the control group. Conclusions: The BP-lowering effects of HEx in resistant HT patients were accompanied by a significant reduction in the marked neurohumoral activation characterizing this clinical condition.
Palavras-chave
Endothelial dysfunction, Heated water-based exercise, Neurohumoral activation, Resistant hypertension
URI
https://observatorio.fm.usp.br/handle/OPI/19997
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11