Treatment-emergent mania/hypomania during antidepressant treatment with transcranial direct current stimulation (tDCS): A systematic review and meta-analysis

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art_BRUNONI_Treatmentemergent_maniahypomania_during_antidepressant_treatment_with_transcranial_direct_2017.PDF (281.4 KB)
Citações na Scopus
44
Tipo de produção
article
Data de publicação
2017
Editora
ELSEVIER SCIENCE INC
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
MOFFA, Adriano H.
GALVEZ, Veronica
LOO, Colleen K.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
BRAIN STIMULATION, v.10, n.2, p.260-262, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Treatment-emergent mania/hypomania (TEM) is a possible adverse effect of pharmacological and non-pharmacological antidepressant treatments. Objective: We performed a systematic review and meta-analysis to evaluate the risk of TEM in depressed patients during randomized, sham-controlled trials (RCTs). Data sources: Medline database, from the first date available to August 12, 2016. Results: From 283 references, 10 RCTs were identified. Only 3 of them described TEM. In active and sham groups, respectively, only 8 of 226 (3.5%) and 1 of 190 (0.5%) participants presented TEM. This difference was not statistically significant (OR = 1.79, 95% CI = 0.6 to 5.32). There were also five additional reports of TEM in participants not on RCTs. No risk factors for TEM were identified. Limitations: Low number of studies and TEM reports. Conclusion: Despite previous reports, active vs. sham tDCS was not associated with a significantly greater number of TEM episodes.
Palavras-chave
Major depressive disorder, Bipolar disorder, Treatment-emergent mania, Manic switch, Transcranial direct current stimulation
URI
https://observatorio.fm.usp.br/handle/OPI/20352
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Coleções
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/27