Semen Analysis and Fertility Rates after Bariatric Surgery in Males
Carregando...
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2017
Título da Revista
ISSN da Revista
Título do Volume
Editora
MARY ANN LIEBERT, INC
Autores
FAINTUCH, Salomao
Citação
BARIATRIC SURGICAL PRACTICE AND PATIENT CARE, v.12, n.3, p.94-99, 2017
Resumo
Background: Obesity poses challenges to male reproduction, but the effect of bariatric surgery on semen parameters and fertility is debated. This study evaluates Roux-en-Y gastric bypass (RYGB) influence on these variables. Methods: Seventy-nine sexually active men attempting to conceive with a partner were stratified into four groups: Group 1 (n = 23)-bariatric follow-up >= 5 years; Group 2 (n = 23)-mean bariatric follow-up 2 years; Group 3-obese controls (n = 18); Group 4-lean controls (n = 15). Groups 2, 3, and 4 were matched for age; Groups 1, 2, and 3 were matched for body mass index (BMI). Sexual quality of life questionnaire for males (SQOL-M), fasting blood glucose, C-reactive protein, vitamin D, zinc, total testosterone (TT), and free testosterone (FT), estradiol (E2), sex hormone-binding globulin (SHBG), and semen parameters were investigated. Results: SQOL-M scores increased; vitamin D was low in most of Group 2 and Group 3 participants, negatively correlating with BMI (p < 0.01). TT, FT, and SHBG improved postoperatively; however, E2 remained elevated. Semen aberrations occurred in 57.1% of Group 2 patients and BMI correlated with oligoasthenoteratospermia. Scant bariatric men fathered a child (13.0% preoperatively, 4.3% postoperatively, not significant). Conclusion: Semen abnormalities and subfertility were observed after RYGB, despite improved androgenic profile and SQOL-M. Possible negative impacts of hyperestrogenism and hypovitaminosis D on semen parameters warrant further studies.
Palavras-chave
bariatric surgery, semen analysis, male fertility, sex hormones, androgens, vitamins, trace elements, male obesity
Referências
- Alexandrou A, 2014, SURG OBES RELAT DIS, V10, P262, DOI 10.1016/j.soard.2013.07.014
- Aquila S, 2009, REPROD BIOL ENDOCRIN, V7, DOI 10.1186/1477-7827-7-140
- Auger J, 2016, HUM REPROD, V31, P10, DOI 10.1093/humrep/dev251
- Bal BS, 2012, NAT REV ENDOCRINOL, V8, P544, DOI 10.1038/nrendo.2012.48
- Bandel I, 2015, HUM REPROD, V30, P1704, DOI 10.1093/humrep/dev111
- Borges JLC, 2017, J CLIN DENSITOM, DOI [10.1016/j.jocd.2017.03.001, DOI 10.1016/J.JOCD.2017.03.001]
- Campbell JM, 2015, REPROD BIOMED ONLINE, V31, P593, DOI 10.1016/j.rbmo.2015.07.012
- Cooper TG, 2010, HUM REPROD UPDATE, V16, P231, DOI 10.1093/humupd/dmp048
- di Frega AS, 2005, HUM REPROD, V20, P997, DOI 10.1093/humrep/deh707
- El Bardisi H, 2016, REPROD BIOMED ONLINE, V33, P606, DOI 10.1016/j.rbmo.2016.08.008
- Kinuta K, 2000, ENDOCRINOLOGY, V141, P1317, DOI 10.1210/en.141.4.1317
- Lazaros L, 2012, ANDROLOGIA, V44, P428, DOI 10.1111/j.1439-0272.2012.01300.x
- Lee DM, 2012, EUR J ENDOCRINOL, V166, P77, DOI 10.1530/EJE-11-0743
- Legro RS, 2015, REPROD BIOMED ONLINE, V30, P150, DOI 10.1016/j.rbmo.2014.10.014
- Nguyen RHN, 2007, HUM REPROD, V22, P2488, DOI 10.1093/humrep/dem139
- Ramlau-Hansen CH, 2007, HUM REPROD, V22, P1634, DOI 10.1093/humrep/dem035
- Reis LO, 2012, REPROD SCI, V19, P1057, DOI 10.1177/1933719112440747
- Rosenblatt A, 2013, SURG OBES RELAT DIS, V9, P636, DOI 10.1016/j.soard.2012.06.010
- Sermondade N, 2013, HUM REPROD UPDATE, V19, P221, DOI 10.1093/humupd/dms050
- Sermondade N, 2012, REPROD BIOMED ONLINE, V24, P206, DOI 10.1016/j.rbmo.2011.10.014
- Takayanagi R, 2002, MECH AGEING DEV, V123, P1107, DOI 10.1016/S0047-6374(01)00394-3
- Tanaka S, 1996, ENDOCRINOLOGY, V137, P1860, DOI 10.1210/en.137.5.1860
- WHO (World Health Organization), 2010, LAB MAN EX PROC HUM