Prophylactic Supplementation of Bifidobacterium longum 5(1A) Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness

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Arquivos
art_MENDES_Prophylactic_Supplementation_of_Bifidobacterium_longum_51A_Protects_Mice_2017.PDF (2.22 MB)
Citações na Scopus
32
Tipo de produção
article
Data de publicação
2017
Editora
FRONTIERS MEDIA SA
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
MENDES, Eduardo
ACETTURI, Beatriz G.
THOMAS, Andrew M.
MARTINS, Flaviano dos S.
CRISMA, Amanda R.
MURATA, Gilson
BRAGA, TarcioT
CAMARA, Niels O. S.
FRANCO, Adriana L. dos S.
SETUBAL, Joao C.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
FRONTIERS IN MICROBIOLOGY, v.8, article ID 1732, 14p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Asthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms and severity in women change during menstruation and menopause. Recently, evidence has demonstrated that interactions among the microbiota, female sex hormones, and immunity are associated with the development of autoimmune diseases. However, no studies have investigated if therapeutic gut microbiota modulation strategies could affect asthma exacerbation during menstruation and menopause. Here we aimed to examine the preventive effects of a probiotic, Bifidobacterium longum 5(1A), on airway inflammation exacerbation in allergic ovariectomized mice. We first evaluated the gut microbiota composition and diversity in mice 10 days after ovariectomy. Next, we examined whether re-exposure of ovariectomized allergic mice to antigen (ovalbumin) would lead to exacerbation of lung inflammation. Finally, we evaluated the preventive and treatment effect of B. longum 5(1A) on lung inflammation and airway hyperresponsiveness. Our results showed that whereas ovariectomy caused no alterations in the gut microbiota composition and diversity in this animal model, 10 days after ovariectomy, preventive use administration of B. longum 5(1A), rather than its use after surgery was capable of attenuate the exacerbated lung inflammation and hyperresponsiveness in ovariectomized allergic mice. This prophylactic effect of B. longum 5(1A) involves acetate production, which led to increased fecal acetate levels and, consequently, increased Treg cells in ovariectomized allergic mice.
Palavras-chave
probiotic, Bifidobacterium longum, airway inflammation, ovariectomy, microbiota
URI
https://observatorio.fm.usp.br/handle/OPI/22190
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/27
Artigos e Materiais de Revistas Científicas - ODS/03