OSTEOMALACIA POR TUMOR SECRETOR DE FGF-23
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Citações na Scopus
6
Tipo de produção
article
Data de publicação
2013
Editora
MEDICINA (BUENOS AIRES)
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Título da Revista
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Título do Volume
Autores
SANCHEZ, Ariel
CASTIGLIONI, Alejandro
COCCARO, Nicolas
SILVA, Roberto
BOBROVSKY, Eduardo
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Citação
MEDICINA-BUENOS AIRES, v.73, n.1, p.43-46, 2013
Resumo
Ostemalacia due to a tumor secreting FGF-23. A case of oncogenic osteomalacia in a 50-year-old male is here presented. He suffered severe bone pain and marked muscular weakness of 4 years' duration. There were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a Looser's zone in the right proximal tibia. An octreotide-Tc scan allowed to identify a small tumor in the posterior aspect of the right knee. It was surgically removed. Microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT). Expression of FGF-23 was documented by immune-peroxidase staining. There was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. The laboratory values returned to normal.
A case of oncogenic osteomalacia in a 50-year-old male is here presented. He suffered severe bone pain and marked muscular weakness of 4 years’ duration. There were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a Looser’s zone in the right proximal tibia. An octreotide-Tc scan allowed to identify a small tumor in the posterior aspect of the right knee. It was surgically removed. Microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT). Expression of FGF-23 was documented by immune-peroxidase staining. There was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. The laboratory values returned to normal.
A case of oncogenic osteomalacia in a 50-year-old male is here presented. He suffered severe bone pain and marked muscular weakness of 4 years’ duration. There were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a Looser’s zone in the right proximal tibia. An octreotide-Tc scan allowed to identify a small tumor in the posterior aspect of the right knee. It was surgically removed. Microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT). Expression of FGF-23 was documented by immune-peroxidase staining. There was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. The laboratory values returned to normal.
Palavras-chave
Osteomalacia oncogénica, Osteomalacia inducida por tumor, Hipofosfatemia, Tumores mesenquimáticos fosfatúricos, FGF-23, Oncogenic osteomalacia, Tumor-induced osteomalacia, Hypophosphatemia, Phosphaturic mesenchymal tumors
Referências
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