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https://observatorio.fm.usp.br/handle/OPI/2307
Title: | OSTEOMALACIA POR TUMOR SECRETOR DE FGF-23 |
Authors: | SANCHEZ, Ariel; CASTIGLIONI, Alejandro; COCCARO, Nicolas; SILVA, Roberto; BOBROVSKY, Eduardo; MOYSES, Rosa M. A.; GRACIOLLI, Fabiana |
Citation: | MEDICINA-BUENOS AIRES, v.73, n.1, p.43-46, 2013 |
Abstract: | Ostemalacia due to a tumor secreting FGF-23. A case of oncogenic osteomalacia in a 50-year-old male is here presented. He suffered severe bone pain and marked muscular weakness of 4 years' duration. There were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a Looser's zone in the right proximal tibia. An octreotide-Tc scan allowed to identify a small tumor in the posterior aspect of the right knee. It was surgically removed. Microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT). Expression of FGF-23 was documented by immune-peroxidase staining. There was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. The laboratory values returned to normal. A case of oncogenic osteomalacia in a 50-year-old male is here presented. He suffered severe bone pain and marked muscular weakness of 4 years’ duration. There were several vertebral deformities in the thoracic spine, bilateral fractures of the iliopubic branches, another fracture in the left ischiopubic branch, and a Looser’s zone in the right proximal tibia. An octreotide-Tc scan allowed to identify a small tumor in the posterior aspect of the right knee. It was surgically removed. Microscopically, it was a phosphaturic mesenchymal tumor-mixed connective tissue (PMT-MCT). Expression of FGF-23 was documented by immune-peroxidase staining. There was rapid improvement, with consolidation of the pelvic fractures and the tibial pseudo-fracture. The laboratory values returned to normal. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/16 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_MOYSES_Ostemalacia_due_to_a_tumor_secreting_FGF_23_2013.PDF | publishedVersion (Spanish) | 555.42 kB | Adobe PDF | View/Open |
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