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NS1-based ELISA test efficiently detects dengue infections without cross-reactivity with Zika virus
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.112, p.202-204, 2021
Objectives: The aim of this study was to achieve greater specificity of dengue virus (DENV) serological tests based on a recombinant antigen derived from non-structural protein 1 (Delta NS1) with regard to cross-reactive Zika virus (ZIKV) anti-NS1 antibody responses. This is of relevance in endem...
One Health approach on human seroprevalence of anti-Toxocara antibodies, Toxocara spp. eggs in dogs and sand samples between seashore mainland and island areas of southern Brazil
ONE HEALTH, v.13, article ID 100353, 7p, 2021
Toxocariasis, caused by Toxocara spp. nematodes, is among the top 5 neglected parasitic diseases worldwide; however, no comprehensive study to date has serologically compared infections in people and their dogs and environmentally contaminated soil or sand of mainland and island locations. Accord...
Painful procedures and pain management in newborns admitted to an intensive care unit
REVISTA DA ESCOLA DE ENFERMAGEM DA USP, v.55, article ID e20210232, 9p, 2021
Objective: To characterize painful procedures, analgesic strategies, vital signs, and pain scores in hospitalized newborns. Method: This is a primary, observational, prospective clinical study, developed in a Brazilian public hospital. Demographic data, painful procedures, pain relief measures, v...
Rationale and pathways forward in the implementation of coronary artery calcium-based enrichment of randomized trials
AMERICAN HEART JOURNAL, v.243, p.54-65, 2022
The Food and Drug Administration recommends prognostic enrichment of randomized controlled trials (RCTs), aimed at restricting the study population to participants most likely to have events and therefore derive benefit from a given intervention. The coronary artery calcium (CAC) score is powerfu...
Long-Term Prognostic Implications and Role of Further Testing in Adults Aged <= 55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis)
AMERICAN JOURNAL OF CARDIOLOGY, v.161, p.26-35, 2021
The long-term prognostic significance of a coronary artery calcium (CAC) score of 0 is poorly defined in younger adults. We evaluated this among participants aged 45 to 55 years from the Multi-Ethnic Study of Atherosclerosis, and assessed whether additional biomarkers can identify subgroups at in...
Antibody- Based Immunotherapy Combined With Antimycotic Drug TMP- SMX to Treat Infection With Paracoccidioides brasiliensis
FRONTIERS IN IMMUNOLOGY, v.12, article ID 725882, 12p, 2021
Monoclonal antibodies (mAbs) are promising alternatives to treat infectious diseases, especially given their potential for applications in combination therapies with antimicrobial drugs to enhance the antifungal efficacy. Protection mediated by mAbs used to treat experimental paracoccidioidomycos...
Ongoing host-shift speciation in Plasmodium simium
TRENDS IN PARASITOLOGY, v.37, n.11, p.940-942, 2021
Plasmodium simium, a malaria parasite that infects platyrrhine monkeys and humans in the New World, is nearly identical to Plasmodium vivax. Recent genomic comparative analyses of these sister species have identified elevated divergence in a gene that may underlie P. simium adaptation to non-huma...
Food insecurity, food waste, food behaviours and cooking confidence of UK citizens at the start of the COVID-19 lockdown
BRITISH FOOD JOURNAL, v.123, n.9, Special Issue, p.2959-2978, 2021
Purpose The current pilot study explored food insecurity, food waste, food related behaviours and cooking confidence of UK consumers following the COVID-19 lockdown. Design/methodology/approach Data were collected from 473 UK-based consumers (63% female) in March 2020. A cross-sectional online su...
School meals consumption is associated with a better diet quality of Brazilian adolescents: results from the PeNSE 2015 survey
PUBLIC HEALTH NUTRITION, v.24, n.18, p.6512-6520, 2021
Objective: To assess the association between the consumption of school meals offered by the National School Feeding Program (PNAE, in the Portuguese acronym) and the diet quality of adolescents aged 11 to 19 years from Brazilian public schools. Design: Cross-sectional. Setting: Public schools in ...
Polygenic risk scores across the extended psychosis spectrum
TRANSLATIONAL PSYCHIATRY, v.11, n.1, article ID 600, 11p, 2021
As early detection of symptoms in the subclinical to clinical psychosis spectrum may improve health outcomes, knowing the probabilistic susceptibility of developing a disorder could guide mitigation measures and clinical intervention. In this context, polygenic risk scores (PRSs) quantifying the ...