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Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SãO PAULO, v.60, p.e8, 2018
ABSTRACT Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes gran...
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The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas
NATURE COMMUNICATIONS, v.14, n.1, 2023
During an infection the immune system produces pathogen-specific antibodies. These antibody repertoires become specific to the history of infections and represent a rich source of diagnostic markers. However, the specificities of these antibodies are mostly unknown. Here, using high-density pepti...
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SARS-CoV-2 Detection and Culture in Different Biological Specimens from Immunocompetent and Immunosuppressed COVID-19 Patients Infected with Two Different Viral Strains
VIRUSES-BASEL, v.15, n.6, article ID 1270, 12p, 2023
Introduction-The dynamics of SARS-CoV-2 shedding and replication in humans remain incompletely understood. Methods-We analyzed SARS-CoV-2 shedding from multiple sites in individuals with an acute COVID-19 infection by weekly sampling for five weeks in 98 immunocompetent and 25 immunosuppressed in...
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Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in Sao Paulo, 2011-2020
MYCOSES, v.66, n.8, p.643-650, 2023
Background: Sporotrichosis is an endemic subcutaneous mycosis classically caused by the Sporothrix schenckii species complex. Recently, sporotrichosis has emerged in Brazil as a cat-transmitted epidemic caused by a new species, Sporothrix brasiliensis. Objectives: To survey the clinical-epidemiol...
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Dynamics and Heterogeneity of the Lung Immunopathology in Severe COVID-19
EUROPEAN RESPIRATORY JOURNAL, v.60, suppl.66, 2022
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Prevalence of Trypanosoma cruzi infection in a cohort of people living with HIV/AIDS from an urban area
EPIDEMIOLOGY AND INFECTION, v.151, article ID e72, 6p, 2023
The prevalence rate of coinfection Chagas disease (CD) and HIV in Brazil is between 1.3 and 5%. Serological tests for detecting CD use total antigen, which present cross reactivity with other endemic diseases, such as leishmaniasis. It is urge the use of a specific test to determinate the real pr...
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Recombinant protein KR95 as an alternative for serological diagnosis of human visceral leishmaniasis in the Americas
PLOS ONE, v.18, n.3, 2023
In the Americas, visceral leishmaniasis (VL) is caused by the protozoan Leishmania infantum, leading to death if not promptly diagnosed and treated. In Brazil, the disease reaches all regions, and in 2020, 1,933 VL cases were reported with 9.5% lethality. Thus, an accurate diagnosis is essential ...
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In vitro miltefosine and amphotericin B susceptibility of strains and clinical isolates of Leishmania species endemic in Brazil that cause tegumentary leishmaniasis
EXPERIMENTAL PARASITOLOGY, v.246, article ID 108462, 7p, 2023
Tegumentary leishmaniasis encompasses a spectrum of clinical manifestations caused by the parasitic protozoa of the genus Leishmania. In Brazil, there are at least seven Leishmania species that are endemic and responsible for this set of clinical manifestations of the disease. Current treatment i...
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Comparative transcriptomic analysis of long noncoding RNAs in Leishmania-infected human macrophages
FRONTIERS IN GENETICS, v.13, article ID 1051568, 17p, 2023
It is well established that infection with Leishmania alters the host cell's transcriptome. Since mammalian cells have multiple mechanisms to control gene expression, different molecules, such as noncoding RNAs, can be involved in this process. MicroRNAs have been extensively studied upon Leishma...
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Respiratory viruses and postoperative hemodynamics in patients with unrestrictive congenital cardiac communications: a prospective cohort study
EUROPEAN JOURNAL OF MEDICAL RESEARCH, v.28, n.1, article ID 38, 16p, 2023
BackgroundPulmonary vascular abnormalities pose a risk for severe life-threatening hemodynamic disturbances following surgical repair of congenital cardiac communications (CCCs). In the distal lung, small airways and vessels share a common microenvironment, where biological crosstalks take place....
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