Instituto de Medicina Tropical - IMT

O Instituto de Medicina Tropical de São Paulo (IMTSP) foi criado em 1959 para desenvolver pesquisas e fornecer subsídio científico e tecnológico para o diagnóstico, tratamento, controle e prevenção das doenças tropicais e grandes endemias do nosso país. Durante 40 anos o IMTSP esteve ligado à Faculdade de Medicina da Universidade de São Paulo, mas, a partir de dezembro de 2000, tornou-se uma unidade autônoma, um Instituto Especializado da USP.

As pesquisas no IMTSP abrangem diversos aspectos da ciência médica nessa área, como o diagnóstico, a patogenia e o tratamento, voltando-se também para as questões epidemiológicas e de prevenção. O IMTSP, além de instituição de pesquisa, também é um centro de formação, de aperfeiçoamento e de prestação de serviços especializados na área: possui um curso regular de extensão sobre saúde dos viajantes, para a comunidade externa e no 2º semestre de 2007 teve o curso de Pós-Graduação em Medicina Tropical e Saúde Internacional aprovado pela Capes.

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Recent Submissions

  1. Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama


    ABSTRACT Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes gran...

  2. The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

    NATURE COMMUNICATIONS, v.14, n.1, 2023

    During an infection the immune system produces pathogen-specific antibodies. These antibody repertoires become specific to the history of infections and represent a rich source of diagnostic markers. However, the specificities of these antibodies are mostly unknown. Here, using high-density pepti...

  3. SARS-CoV-2 Detection and Culture in Different Biological Specimens from Immunocompetent and Immunosuppressed COVID-19 Patients Infected with Two Different Viral Strains

    VIRUSES-BASEL, v.15, n.6, article ID 1270, 12p, 2023

    Introduction-The dynamics of SARS-CoV-2 shedding and replication in humans remain incompletely understood. Methods-We analyzed SARS-CoV-2 shedding from multiple sites in individuals with an acute COVID-19 infection by weekly sampling for five weeks in 98 immunocompetent and 25 immunosuppressed in...

  4. Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in Sao Paulo, 2011-2020

    MYCOSES, v.66, n.8, p.643-650, 2023

    Background: Sporotrichosis is an endemic subcutaneous mycosis classically caused by the Sporothrix schenckii species complex. Recently, sporotrichosis has emerged in Brazil as a cat-transmitted epidemic caused by a new species, Sporothrix brasiliensis. Objectives: To survey the clinical-epidemiol...

  5. Dynamics and Heterogeneity of the Lung Immunopathology in Severe COVID-19

    EUROPEAN RESPIRATORY JOURNAL, v.60, suppl.66, 2022

  6. Prevalence of Trypanosoma cruzi infection in a cohort of people living with HIV/AIDS from an urban area

    EPIDEMIOLOGY AND INFECTION, v.151, article ID e72, 6p, 2023

    The prevalence rate of coinfection Chagas disease (CD) and HIV in Brazil is between 1.3 and 5%. Serological tests for detecting CD use total antigen, which present cross reactivity with other endemic diseases, such as leishmaniasis. It is urge the use of a specific test to determinate the real pr...

  7. Recombinant protein KR95 as an alternative for serological diagnosis of human visceral leishmaniasis in the Americas

    PLOS ONE, v.18, n.3, 2023

    In the Americas, visceral leishmaniasis (VL) is caused by the protozoan Leishmania infantum, leading to death if not promptly diagnosed and treated. In Brazil, the disease reaches all regions, and in 2020, 1,933 VL cases were reported with 9.5% lethality. Thus, an accurate diagnosis is essential ...

  8. In vitro miltefosine and amphotericin B susceptibility of strains and clinical isolates of Leishmania species endemic in Brazil that cause tegumentary leishmaniasis

    EXPERIMENTAL PARASITOLOGY, v.246, article ID 108462, 7p, 2023

    Tegumentary leishmaniasis encompasses a spectrum of clinical manifestations caused by the parasitic protozoa of the genus Leishmania. In Brazil, there are at least seven Leishmania species that are endemic and responsible for this set of clinical manifestations of the disease. Current treatment i...

  9. Comparative transcriptomic analysis of long noncoding RNAs in Leishmania-infected human macrophages

    FRONTIERS IN GENETICS, v.13, article ID 1051568, 17p, 2023

    It is well established that infection with Leishmania alters the host cell's transcriptome. Since mammalian cells have multiple mechanisms to control gene expression, different molecules, such as noncoding RNAs, can be involved in this process. MicroRNAs have been extensively studied upon Leishma...

  10. Respiratory viruses and postoperative hemodynamics in patients with unrestrictive congenital cardiac communications: a prospective cohort study

    EUROPEAN JOURNAL OF MEDICAL RESEARCH, v.28, n.1, article ID 38, 16p, 2023

    BackgroundPulmonary vascular abnormalities pose a risk for severe life-threatening hemodynamic disturbances following surgical repair of congenital cardiac communications (CCCs). In the distal lung, small airways and vessels share a common microenvironment, where biological crosstalks take place....