Laboratórios de Investigação Médica - LIMs

Os Laboratórios de Investigação Médica (LIMs) foram criados em decorrência da Reforma Universitária de 1969 (Lei de Diretrizes e Bases da Educação Nacional), implantada em 1970, através da qual os laboratórios de pesquisa passaram a ocupar área física da Faculdade e a receber materiais e recursos humanos do Hospital das Clínicas. Pelo Decreto 9720 de 20 de abril de 1977, o Hospital das Clínicas FMUSP incorporou os Laboratórios de Investigação Médica.

Os LIMs abrigam mais de 200 grupos de pesquisa, que são acadêmica e cientificamente vinculados aos Departamentos da FMUSP e administrativamente vinculados ao HC-FMUSP; possuindo as seguintes finalidades: desenvolver pesquisa científica; padronizar novas técnicas e métodos de diagnóstico possibilitando sua implantação para atendimento de pacientes em outras unidades do HC; promover a formação de pesquisadores em pesquisa básica e aplicada; servir de campo de ensino e treinamento de estudantes de escolas de nível superior cujos currículos sejam relacionados com as ciências da saúde; servir de campo de desenvolvimento e treinamento para profissionais da saúde e realizar cursos no campo da medicina e da saúde.

Site oficial:


Sub-communities within this community

Collections in this community


Recent Submissions

  1. Skin innate immune response against fungal infections and the potential role of trained immunity

    MYCOSES, v.67, n.1, article ID e13682, 11p, 2024

    Fungal skin infections are distributed worldwide and can be associated with economic and social traits. The immune response related to skin cells is complex and its understanding is essential to the comprehension of each cell's role and the discovery of treatment alternatives. The first studies o...

  2. Cone-beam computed tomography texture analysis can help differentiate odontogenic and non-odontogenic maxillary sinusitis

    IMAGING SCIENCE IN DENTISTRY, v.53, n.1, p.43-51, 2023

    Purpose: This study aimed to assess texture analysis (TA) of cone-beam computed tomography (CBCT) images as a quantitative tool for the differential diagnosis of odontogenic and non-odontogenic maxillary sinusitis (OS and NOS, respectively).Materials and Methods: CBCT images of 40 patients diagno...

  3. Noninvasive Techniques for Management of Erythema Multiforme

    CASE REPORTS IN DENTISTRY, v.2023, article ID 9938939, 4p, 2023

    An 18-year-old man was referred for a diagnosis of extensive oral lesions. During the interview, he reported a medical history of ganglionic tuberculosis, type 2 herpes infection, and significant weight loss due to dysphagia. Intraoral exam revealed multiple painful and ulcerated lesions covered ...

  4. Liver steatosis as a predictor of incident diabetes in adults: a prospective evaluation in the Brazilian Longitudinal Study of Adult<i> Health</i> (ELSA-Brasil)

    CADERNOS DE SAUDE PUBLICA, v.39, n.3, article ID e00090522, 11p, 2023

    Increasing epidemiological evidence suggests a bidirectional relationship be-tween non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and that NAFLD may precede and/or promote the development of diabetes. This study aimed to investigate whether liver steatosis is associated with the i...

  5. Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study

    SCHIZOPHRENIA BULLETIN, v.50, n.1, p.145-156, 2024

    Background and Hypothesis: Aerobic exercise interventions in people with schizophrenia have been demonstrated to improve clinical outcomes, but findings regarding the underlying neural mechanisms are limited and mainly focus on the hippocampal formation. Therefore, we conducted a global explorato...

  6. Publishing Negative Results of Neurobiological Studies in Mental Disorders Will Advance Knowledge in Pathophysiology

    SCHIZOPHRENIA BULLETIN, v.49, n.3, p.539-541, 2023

  7. Exercise as an add-on treatment in individuals with schizophrenia: Results from a large multicenter randomized controlled trial

    PSYCHIATRY RESEARCH, v.328, article ID 115480, 11p, 2023

    Current treatment methods do not achieve recovery for most individuals with schizophrenia, and symptoms such as negative symptoms and cognitive deficits often persist. Aerobic endurance training has been suggested as a potential add-on treatment targeting both physical and mental health. We perfo...

  8. Treatment of negative symptoms in schizophrenia: a challenge for clinical research


  9. Systemic corticosteroids in fibrotic lung disease: a systematic review and meta-analysis

    BMJ OPEN RESPIRATORY RESEARCH, v.10, n.1, article ID e002008, 9p, 2023

    ObjectivesWe aimed to assess the available evidence for corticosteroids in fibrotic interstitial lung disease (fILD) to inform the randomised embedded multifactorial adaptive platform ILD.DesignSystematic review and meta-analysis.Data sourcesWe searched Embase, Medline, Cochrane CENTRAL and Web o...

  10. Beyond Sex-Based Differences: Exploring the Complexities of Aortic Stenosis in Women