LIM/18 - Laboratório de Carboidratos e Radioimunoensaios

O Laboratório de Carboidratos e Radioimunoensaios é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: tratamento do diabetes; autoimunidade e genética em diabetes tipo 1; síndrome metabólica; sinalização insulínica; genética do diabetes tipo 2; obesidade e cirurgia metabólica.

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Recent Submissions

  1. Effects of Small-Sided Soccer Games on Physical Fitness, Physiological Responses, and Health Indices in Untrained Individuals and Clinical Populations: A Systematic Review

    SPORTS MEDICINE, v.50, n.5, p.987-1007, 2020

    Background Small-sided soccer games (SSSG) are a specific exercise regime with two small teams playing against each other on a relatively small pitch. There is evidence from original research that SSSG exposure provides performance and health benefits for untrained adults. Objectives The aim of t...

  2. Serum albumin modified by carbamoylation impairs macrophage cholesterol efflux in diabetic kidney disease

    JOURNAL OF DIABETES AND ITS COMPLICATIONS, v.35, n.9, article ID 107969, 8p, 2021

    Background and aims: Abnormalities in lipid metabolism, accumulation of uremic toxins and advanced glycation end products may contribute to worsening atherosclerosis. This study characterized the glycation and carbamoylation profile of serum albumin isolated from individuals with diabetic kidney ...

  3. Semiologia do paciente obeso

    Mancini, Marcio C.. Semiologia do paciente obeso. In: Martins, Milton de Arruda; Quintino, Carla Romagnolli; Tibério, Iolanda de Fátima L. Calvo; Atta, José Antonio; Ivanovic, Lígia Fidelis (eds). Semiologia Clínica. SANTANA DE PARNAIBA: Manole, 2021. p.520-523.

  4. Postprandial glucose-lowering effect of cagaita (Eugenia dysenterica DC) fruit juice in dysglycemic subjects with metabolic syndrome: An exploratory study

    FOOD RESEARCH INTERNATIONAL, v.142, article ID 110209, 7p, 2021

    Cagaita (Eugenia dysenterica DC) is an ellagitannin-containing Myrtaceae fruit from Cerrado biome. This fruit seems to be a promising candidate for an adjuvant in glucose regulation in healthy subjects. However, it is not known whether cagaita juice would have the same effect on dysglycemic subje...

  5. Type 2 diabetes and metabolic surgery guidelines and recommendations should urgently be unified

    ACTA DIABETOLOGICA, v.58, n.4, p.531-536, 2021

    Metabolic surgery has been studied in the last decades as an effective and safe treatment for type 2 diabetes (T2D), and randomized controlled trials generally found surgery superior when compared with medical treatment. In 2016, the DSS-II Joint Statement recognized the importance of metabolic s...

  6. Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease

    SCIENTIFIC REPORTS, v.11, n.1, article ID 4722, 20p, 2021

    CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad spectrum of renal disorders. Pharmacogenetic studies have reported inconsistent linkages between CYP3A5 expression and hypertension, however, most investigators have co...

  7. Pharmacokinetics of oral levonorgestrel and ethinylestradiol in women after Roux-en-Y gastric bypass surgery

    SURGERY FOR OBESITY AND RELATED DISEASES, v.17, n.4, p.673-681, 2021

    Background: Most patients undergoing Roux-en-Y gastric bypass (RYGB) are women in reproductive age. It is not known if bariatric surgery affects the pharmacokinetics of oral contraceptives. Objectives: The primary objective was to evaluate ethinylestradiol (EE) and levonorgestrel (LNG) absorption...

  8. Ocular Manifestations and Neuropathy in Type 2 Diabetes Patients With Charcot Arthropathy

    FRONTIERS IN ENDOCRINOLOGY, v.12, article ID 585823, 8p, 2021

    Objective Diabetes can affect the eye in many ways beyond retinopathy. This study sought to evaluate ocular disease and determine any associations with peripheral neuropathy (PN) or cardiac autonomic neuropathy (CAN) in type 2 diabetes (T2D) and Charcot arthropathy (CA) patients. Design A total o...

  9. A Hybrid Model to Predict Glucose Oscillation for Patients with Type 1 Diabetes and Suggest Customized Recommendations

    INTELLIGENT SYSTEMS AND APPLICATIONS, VOL 2, v.1038, p.790-801, 2020

    The number of adults with Diabetes Mellitus has quadrupled in the last few years around the world, and its prevalence is steadily increasing. Several mathematical and agent-based models have been proposed to shape the human glucose-insulin regulatory system and its ultradian oscillations. However...

  10. Controlled obesity status: a rarely used concept, but with particular importance in the COVID-19 pandemic and beyond


    Obesity is a chronic disease that causes and aggravates several other diseases, and early reports suggest it is an important risk factor for COVID-19 severity. Although a deeper understanding of this relationship is vital, it is also important to inform the general public about the risks and, ide...