• Leukotriene Pathway Activation Associates with Poor Glycemic Control and with Cardiovascular Autonomic Neuropathy in Type 1 Diabetes 

  SANTOS-BEZERRA, Daniele P.; FILGUEIRAS, Luciano R.; MONTEIRO, Maria Beatriz; ADMONI, Sharon N.; V, Ricardo Perez; CAVALEIRO, Ana M.; MACHADO, Cleide G.; MACHADO, Ubiratan F.; PASSARELLI, Marisa; JANCAR, Sonia; CORREA-GIANNELLA, Maria Lucia (HINDAWI LTD, LONDON, ENGLAND, 2020)

  Background and Aims. Since hyperglycemia promotes inflammation by different pathways and inflammation participates in the development of chronic diabetes complications, we investigated the association between the leukotriene ...
• Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission 

  ASSAL, Karina Al; PRIFTI, Edi; BELDA, Eugeni; SALA, Priscila; CLEMENT, Karine; DAO, Maria-Carlota; DORE, Joel; LEVENEZ, Florence; TADDEI, Carla R.; FONSECA, Danielle Cristina; ROCHA, Ilanna Marques; BALMANT, Bianca Depieri; THOMAS, Andrew Maltez; SANTO, Marco A.; DIAS-NETO, Emmanuel; SETUBAL, Joao Carlos; ZUCKER, Jean-Daniel; BELARMINO, Giliane; TORRINHAS, Raquel Susana; WAITZBERG, Dan L. (MDPI, BASEL, SWITZERLAND, 2020)

  Gut microbiota composition is influenced by environmental factors and has been shown to impact body metabolism. Objective: To assess the gut microbiota profile before and after Roux-en-Y gastric bypass (RYGB) and the ...
• Dual SGLT1/SGLT2 Inhibitor Phlorizin Ameliorates Non-Alcoholic Fatty Liver Disease and Hepatic Glucose Production in Type 2 Diabetic Mice 

  DAVID-SILVA, Aline; ESTEVES, Joao Victor; MORAIS, Mychel Raony P. T.; FREITAS, Helayne Soares; ZORN, Telma Maria; CORREA-GIANNELLA, Maria Lucia; MACHADO, Ubiratan Fabres (DOVE MEDICAL PRESS LTD, ALBANY, NEW ZEALAND, 2020)

  Purpose: NAFLD is a hepatic component of type 2 diabetes mellitus (T2D), in which impaired hepatic glucose production plays an important role. Inhibitors of sodium glucose transporter 2 (SGLT2) reduce glycemia and exert ...
• Reproducibility of a nylon fishing line as a screening test for diabetic foot ulceration risk 

  MATOS, Mozania Reis de; SANTOS-BEZERRA, Daniele Pereira; CORREA-GIANNELLA, Maria Lucia (HOSPITAL CLINICAS, UNIV SAO PAULO, SAO PAULO, BRAZIL, 2020)
• Key factors for overcoming psychological insulin resistance: an examination of patient perspectives through content analysis 

  STUCKEY, Heather; FISHER, Lawrence; POLONSKY, William H.; HESSLER, Danielle; SNOEK, Frank J.; TANG, Tricia S.; HERMANNS, Norbert; MUNDET--TUDURI, Xavier; SILVA, Maria Elizabeth Rossi da; STURT, Jackie; OKAZAKI, Kentaro; CAO, Dachuang; HADJIYIANNI, Irene; IVANOVA, Jasmina I.; DESAI, Urvi; PEREZ-NIEVES, Magaly (BMJ PUBLISHING GROUP, LONDON, ENGLAND, 2019)

  Objective To understand participant perceptions about insulin and identify key behaviors of healthcare professionals (HCPs) that motivated initially reluctant adults from seven countries (n=40) who had type 2 diabetes (T2D) ...
• Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages 

  OKUDA, Ligia Shimabukuro; IBORRA, Rodrigo Tallada; RAMOS, Paula; MACHADO, Ubiratan Fabres; CORREA-GIANNELLA, Maria Lucia; PICKFORD, Russell; WOODS, Tom; BRIMBLE, Margaret Anne; RYE, Kerry-Anne; PASSARELLI, Marisa (HINDAWI LTD, LONDON, ENGLAND, 2020)

  We addressed how advanced glycation (AGE) affects the ability of apoA-IV to impair inflammation and restore the expression of genes involved in cholesterol efflux in lipopolysaccharide- (LPS-) treated macrophages. Recombinant ...
• Identification and performance of multiple clinical and laboratorial risk factors for diagnosis of cardiac autonomic neuropathy in type 1 diabetes patients 

  RIGUETTO, Cinthia Minatel; TAKANO, Caroline Rigoleto; ADMONI, Sharon Nina; PARISI, Maria Candida Ribeiro; GIANNELLA, Maria Lucia Correa; PAVIN, Elizabeth Joao; MOURA NETO, Arnaldo (SPRINGER INTERNATIONAL PUBLISHING AG, CHAM, SWITZERLAND, 2019)

  Purpose The incidence of cardiac autonomic neuropathy (CAN) in patients with type 1 diabetes (T1D) is frequently underestimated. Individuals with T1D and CAN have an increased mortality risk, mainly from cardiovascular ...
• Insulin Glargine U100 Improved Glycemic Control and Reduced Nocturnal Hypoglycemia in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease Stages 3 and 4 

  BETONICO, Carolina C.; TITAN, Silvia Maria O.; LIRA, Aecio; PELAES, Tatiana S.; CORREA-GIANNELLA, Maria Lucia C.; NERY, Marcia; QUEIROZ, Marcia (ELSEVIER, BRIDGEWATER, USA, 2019)

  Purpose: Glycemic control in patients with chronic kidney disease (CKD) is particularly hard to achieve because of a slower insulin degradation by the kidney. It might modify the long-acting insulin analogue pharmacokinetics, ...
• MicroRNAs 1915-3p, 2861, and 4532 Are Associated with Long-Term Renal Function Decline in Type 1 Diabetes 

  MONTEIRO, Maria Beatriz; SANTOS-BEZERRA, Daniele P.; PELAES, Tatiana S.; VAIDYA, Vishal S.; CORREA-GIANNELLA, Maria Lucia (AMER ASSOC CLINICAL CHEMISTRY, WASHINGTON, USA, 2019)
• Fecal bile acid profile after Roux-en-Y gastric bypass and its association with the remission of type 2 diabetes in obese women: A preliminary study 

  CARDINELLI, Camila de Siqueira; TORRINHAS, Raquel Susana; SALA, Priscila; PUDENZI, Marcos Albieri; ANGOLINI, Celio Fernando F.; SILVA, Mariane Marques da; MACHADO, Natasha Mendonca; RAVACCI, Graziela; EBERLIN, Marcos N.; WAITZBERG, Dan L. (CHURCHILL LIVINGSTONE, EDINBURGH, SCOTLAND, 2019)

  Objective: To assess the influence of Roux-en-Y gastric by-pass (RYGB) on fecal bile acid (BA) profile and its relationship with postoperative remission of type 2 diabetes (T2D). Methods: Fecal samples were collected 3 and ...
• Highlight article: Dietary protein and exercise for preservation of lean mass and perspectives on type 2 diabetes prevention 

  SOUSA, Maysa Vieira de; SOARES, Diana Bento da Silva; CARACA, Elaine Reis; CARDOSO, Ronaldo (SAGE PUBLICATIONS LTD, LONDON, ENGLAND, 2019)

  Sedentary lifestyle and aging favor the increasing prevalence of obesity and type 2 diabetes and their comorbidities. The loss of lean body mass reduces muscle strength, resulting in impaired functional capacity and leading ...
• Biomarkers of insulin action during single soccer sessions before and after a 12-week training period in type 2 diabetes patients on a caloric-restricted diet 

  SOUSA, Maysa V. de; FUKUI, Rosa; DAGOGO-JACK, Samuel; KRUSTRUP, Peter; ZOUHAL, Hassane; SILVA, Maria Elizabeth R. da (PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, ENGLAND, 2019)

  Background: We investigated the biomarkers of insulin action as well as changes in free fatty acids and lactate concentration after an acute soccer session pre and post training with caloric-restricted diet versus diet ...
• Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes 

  ADMONI, Sharon Nina; SANTOS-BEZERRA, Daniele Pereira; PEREZ, Ricardo Vesoni; PATENTE, Thiago Andrade; MONTEIRO, Maria Beatriz; CAVALEIRO, Ana Mercedes; PARISI, Maria Candida; NETO, Arnaldo Moura; PAVIN, Elizabeth Joao; QUEIROZ, Marcia Silva; NERY, Marcia; CORREA-GIANNELLA, Maria Lucia (SAGE PUBLICATIONS LTD, LONDON, ENGLAND, 2019)

  Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione ...
• Early age at menarche: A risk factor for overweight or obesity in patients with type 1 diabetes living in urban areas? 

  GOMES, M. B.; NEGRATO, C. A.; CALLIARI, L. E. P. (ELSEVIER IRELAND LTD, CLARE, IRELAND, 2015)

  Aims: Determine the relationship between age at menarche, glycemic control and cardiovascular risk factors in patients with type 1 diabetes living in urban areas. Methods: This was a multicenter cross-sectional study ...
• Hypoglycemia incidence and awareness among insulin-treated patients with diabetes: the HAT study in Brazil 

  LAMOUNIER, Rodrigo Nunes; GELONEZE, Bruno; LEITE, Silmara Oliveira; MONTENEGRO JR., Renan; ZAJDENVERG, Lenita; FERNANDES, Milene; GRICIUNAS, Fabiano de Oliveira; ERMETICE, Mariana Narbot; CHACRA, Antonio Roberto (BMC, LONDON, ENGLAND, 2018)

  Background: Hypoglycemia affects patient safety and glycemic control during insulin treatment of both type 1 (T1DM) and type 2 diabetes mellitus (T2DM). The Hypoglycemia Assessment Tool study in Brazil aimed to determine ...
• Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents 

  MARRA, Nivea Fazanaro; FERNANDES, Maria Teresa Bechere; MELO, Maria Edna de; CRUZ, Rodrigo Marques da; TESS, Beatriz Helena (WILEY, HOBOKEN, USA, 2019)

  Aim We aimed to assess the influence of fasting insulin resistance on metabolically healthy obesity (MHO) prevalence in adolescents and to identify associated factors. Methods This retrospective, registry-based, cross-sectional ...
• Prognostic value of energy expenditure and respiratory quotient measuring in patients with liver cirrhosis 

  BELARMINO, G.; SINGER, P.; GONZALEZ, M. C.; MACHADO, N. M.; CARDINELLI, C. S.; BARCELOS, S.; ANDRAUS, W.; D'ALBUQUERQUE, L. A. C.; DAMIANI, L.; COSTA, A. C.; PEREIRA, R. M. R.; HEYMSFIELD, S. B.; SALA, P.; TORRINHAS, R. S. M.; WAITZBERG, D. L. (CHURCHILL LIVINGSTONE, EDINBURGH, SCOTLAND, 2019)

  Background & aims: Resting energy expenditure (REE) and respiratory quotient (RQ) as measured by indirect calorimetry (IC) may correlate with muscle mass and represent prognostic indicators in treating patients with liver ...
• Increased Expression of Circulating microRNA 101-3p in Type 1 Diabetes Patients: New Insights Into miRNA-Regulated Pathophysiological Pathways for Type 1 Diabetes 

  SANTOS, Aritania S.; NETO, Edecio Cunha; FUKUI, Rosa T.; FERREIRA, Ludmila R. P.; SILVA, Maria Elizabeth R. (FRONTIERS MEDIA SA, LAUSANNE, SWITZERLAND, 2019)

  MicroRNAs (miRs) are master regulators of post-transcriptional gene expression, and they are often dysregulated in individuals suffering from diabetes. We investigated the roles of miR-101-3p and miR-204-5p, both of which ...
• Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes 

  MARSO, Steven P.; DANIELS, Gilbert H.; BROWN-FRANDSEN, Kirstine; KRISTENSEN, Peter; MANN, Johannes F. E.; NAUCK, Michael A.; NISSEN, Steven E.; POCOCK, Stuart; POULTER, Neil R.; RAVN, Lasse S.; STEINBERG, William M.; STOCKNER, Mette; ZINMAN, Bernard; BERGENSTAL, Richard M.; BUSE, John B. (MASSACHUSETTS MEDICAL SOC, WALTHAM, USA, 2016)

  BACKGROUND The cardiovascular effect of liraglutide, a glucagon-like peptide 1 analogue, when added to standard care in patients with type 2 diabetes, remains unknown. METHODS In this double-blind trial, we randomly assigned ...
• Liraglutide and Renal Outcomes in Type 2 Diabetes 

  MANN, Johannes F. E.; ORSTED, David D.; BROWN-FRANDSEN, Kirstine; MARSO, Steven P.; POULTER, Neil R.; RASMUSSEN, Soren; TORNOE, Karen; ZINMAN, Bernard; BUSE, John B. (MASSACHUSETTS MEDICAL SOC, WALTHAM, USA, 2017)

  BACKGROUND In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found ...

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