LIM/15 - Laboratório de Investigação em Neurologia

O Laboratório de Investigação em Neurologia é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: líquido cefalorraquiano; neuroinfecção; demências; biologia molecular e celular dos tumores do sistema nervoso central; miopatias; anticonvulsivantes; estresse oxidativo em distúrbios cognitivos e do comportamento; estimulação magnética transcraniana.

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Recent Submissions

  1. Direct oral anticoagulants for the treatment of cerebral venous thrombosis - a protocol of an international phase IV study

    FRONTIERS IN NEUROLOGY, v.14, article ID 1251581, 9p, 2023

    Introduction: Current guidelines recommend that patients with cerebral venous thrombosis (CVT) should be treated with vitamin K antagonists (VKAs) for 3-12 months. Direct oral anticoagulants (DOACs), however, are increasingly used in clinical practice. An exploratory randomized controlled trial i...

  2. White Matter Integrity and Chronic Poststroke Upper Limb Function: An ENIGMA Stroke Recovery Analysis

    STROKE, v.54, n.9, p.2438-2441, 2023

    BACKGROUND:Integrity of the corticospinal tract (CST) is an important biomarker for upper limb motor function following stroke. However, when structurally compromised, other tracts may become relevant for compensation or recovery of function.METHODS:We used the ENIGMA Stroke Recovery data set, a ...

  3. The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States


    Introduction: The Brazilian population in the United States (U.S.), a Latinx subgroup, is rapidly growing and aging but remains underrepresented in U.S. health research. In addition to group-specific genetic and environmental risks, Brazilian immigrants and their offspring in the U.S. likely have...

  4. The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States ( vol 9, e12425, 2023)


  5. Stroke in vascular Ehlers-Danlos syndrome

    PRACTICAL NEUROLOGY, v.23, n.5, p.436-438, 2023

  6. Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors

    CURRENT ALZHEIMER RESEARCH, v.20, n.5, p.341-349, 2023

    Background: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are important causes of dementia with challenging differential diagnoses in many cases. Addenbrooke's Cognitive Examination-Revised (ACE-R) is a cognitive battery that may be useful to differentiate the tw...

  7. Musashi-1 regulates cell cycle and confers resistance to cisplatin treatment in Group 3/4 medulloblastomas cells

    HUMAN CELL, v.36, n.6, p.2129-2139, 2023

    Groups (Grp) 3 and 4 are aggressive molecular subgroups of medulloblastoma (MB), with high rates of leptomeningeal dissemination. To date, there is still a paucity of biomarkers for these subtypes of MBs. In this study, we investigated the clinical significance and biological functions of Musashi...

  8. A case of mitochondrial DNA depletion syndrome type 11-expanding the genotype and phenotype

    NEUROMUSCULAR DISORDERS, v.33, n.8, p.692-696, 2023

    Mitochondrial DNA depletion syndrome type 11 (MTDPS11) is caused by pathogenic variants in MGME1 gene. We report a woman, 40-year-old, who presented slow progressive drop eyelid at 11-year old with, learning difficulty and frequent falls. Phisical examination revealed: mild scoliosis, elbow hyper...

  9. New observations on minifascicular neuropathy with sex-dependent gonadal dysgenesis: a case series with nerve ultrasound assessment

    NEUROLOGICAL SCIENCES, v.44, n.10, p.3691-3696, 2023

    BackgroundGonadal dysgenesis with minifascicular neuropathy (GDMN) is a rare autosomal recessive condition associated with biallelic DHH pathogenic variants. In 46, XY individuals, this disorder is characterized by an association of minifascicular neuropathy (MFN) and gonadal dysgenesis, while in...

  10. Orbicularis Oculi Muscle Immunohistochemical, Metabolic, and Morphometric Differences in Affected and Nonaffected Sides in Hemifacial Spasm vs Healthy Subjects

    JOURNAL OF NEURO-OPHTHALMOLOGY, v.43, n.3, p.410-416, 2023

    Background:Subtle morphological alterations have been reported even in the nonaffected side of the orbicularis oculi muscle in patients with hemifacial spasm. However, no previous study assessed immunohistochemical, metabolic, and morphometric alterations in orbicularis oculi muscle fibers in aff...