LIM/15 - Laboratório de Investigação em Neurologia

LIM/15 - Laboratório de Investigação em Neurologia

 

O Laboratório de Investigação em Neurologia é ligado ao Departamento de Neurocirurgia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: líquido cefalorraquiano; neuroinfecção; demências; biologia molecular e celular dos tumores do sistema nervoso central; miopatias; anticonvulsivantes; estresse oxidativo em distúrbios cognitivos e do comportamento; estimulação magnética transcraniana.

Site oficial: http://www.limhc.fm.usp.br/portal/lim15-laboratorio-de-investigacao-em-neurologia/

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Recent Submissions

  • CORDEIRO, Isis S. F.; CORDEIRO, Lilian; WAGNER, Carolina S.; ARAUJO, Luiza Karla R. P.; PEREIRA, Benedito J.; ABENSUR, Hugo; ELIAS, Rosilene M.; SILVA, Bruno C. (KARGER, BASEL, SWITZERLAND, 2020)
    Background: Patients undergoing maintenance hemodialysis (HD) exhibit increased levels of uremic toxins, which are associated with poor outcomes. Recently, new dialysis membranes have allowed clearance of solutes with ...
  • STERMAN-NETO, H.; HEISE, C. O.; SIQUEIRA, M. G.; MARTINS, R. S.; TAVARES, P. L.; FORONI, L. H. (ELSEVIER, AMSTERDAM, NETHERLANDS, 2020)
    Objectives: Making the diagnosis of root avulsion in traumatic brachial plexus injuries is important but sometimes difficult. The histamine test for differentiating between pre- and post-ganglionic lesions is a simple, ...
  • JACOMASSO, Thiago; RIBAS, Hennrique Taborda; TROMBETTA-LIMA, Marina; KONIG, Michelle Silberspitz; TRINDADE, Edvaldo Silva; MARTINEZ, Glaucia Regina; SOGAYAR, Mari Cleide; WINNISCHOFER, Sheila Maria Brochado (LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA, USA, 2020)
    The reversion-inducing cysteine-rich protein with kazal motifs (RECK) gene was described as a tumor suppressor gene two decades ago. Recently, novel alternatively spliced products of this gene have been identified. Of ...
  • PEREIRA, Benedito Jamilson Araujo; SANTANA JUNIOR, Pedro Augustto de; ALMEIDA, Antonio Nogueira de; CAVALCANTE, Stella Goncalves; MELO, Keyde Cristina Martins de; AGUIAR, Paulo Henrique Pires de; PAIVA, Wellingson da Silva; OBA-SHINJO, Sueli Mieko; MARIE, Suely Kazue Nagahashi (ELSEVIER, AMSTERDAM, NETHERLANDS, 2020)
    Objective: The aim of the present study was to analyze if the pathway Skp2-p27-cyclin El could also be a tumor progression marker for meningiomas. Patients and methods: We used quantitative real-time PCR to assess the ...
  • PEREIRA, Benedito Jamilson Araujo; ALMEIDA, Antonio Nogueira de; PAIVA, Wellingson Silva; AGUIAR, Paulo Henrique Pires de; TEIXEIRA, Manoel Jacobsen; MARIE, Suely Kazue Nagahashi (SPRINGER, NEW YORK, UNITED STATES, 2020)
    Review the data published on the subject to create a more comprehensive natural history of intraventricular meningiomas (IVMs). A Medline search up to March 2018 using ""intraventricular meningioma"" returned 98 papers. ...
  • MA, Jianhui; BENITEZ, Jorge A.; LI, Jie; MIKI, Shunichiro; ALBUQUERQUE, Claudio Ponte de; GALATRO, Thais; ORELLANA, Laura; ZANCA, Ciro; REED, Rachel; BOYER, Antonia; KOGA, Tomoyuki; VARKI, Nissi M.; FENTON, Tim R.; MARIE, Suely Kazue Nagahashi; LINDAHL, Erik; GAHMAN, Timothy C.; SHIAU, Andrew K.; ZHOU, Huilin; DEGROOT, John; SULMAN, Erik P.; CAVENEE, Webster K.; KOLODNER, Richard D.; CHEN, Clark C.; FURNARI, Frank B. (CELL PRESS, CAMBRIDGE, USA, 2019)
  • ZANOTELI, Edmar; SOARES, Priscilla Souza; SILVA, Andre Macedo Serafim da; CAMELO, Clara Gontijo; FONSECA, Alulin Tacio Quadros Santos Monteiro; ALBUQUERQUE, Marco Antinio Veloso; MORENO, Cristiane Araujo Martins; ABATH NETO, Osorio Lopes; NOVO FILHO, Gil Monteiro; KULIKOWSKI, Leslie Domenici; REED, Umbertina Conti (ELSEVIER, AMSTERDAM, NETHERLANDS, 2020)
    Objectives: Collagen VI-related dystrophies (COL6-RDs) have a broad clinical spectrum and are caused by mutations in the COL6A1, COL6A2 and COL6A3 genes. Despite the clinical variability, two phenotypes are classically ...
  • MORENO, Cristiane Araujo Martins; ESTEPHAN, Eduardo de Paula; FAPPI, Alan; MONGES, Soledad; LUBIENIECKI, Fabiana; ABATH NETO, Osorio Lopes; REED, Umbertina Conti; DONKERVOORT, Sandra; HARMS, Matthew B.; BONNEMANN, Carsten; ZANOTELI, Edmar (PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, ENGLAND, 2020)
    Congenital fiber type disproportion (CFTD) is a rare congenital myopathy subtype defined by slow type 1 hypotrophy in the absence of any other major structural findings such as rods, central nuclei or cores. Dominant ...
  • BARBOSA, Breno J. A. P.; SOUZA-TALARICO, Juliana N. de; NITRINI, Ricardo; BRUCKI, Sonia M. D. (LIPPINCOTT WILLIAMS & WILKINS, PHILADELPHIA, USA, 2019)
  • PEREIRA, B. Jamilson Araujo; ALMEIDA, A. Nogueira de; AGUIAR, P. Henrique Pires de; PAIVA, W. Silva; TEIXEIRA, M. Jacobsen; MARIE, S. Kazue Nagahashi (MASSON EDITEUR, MOULINEAUX CEDEX 9, FRANCE, 2020)
    Purpose. - To evaluate the relationship between meningioma histological subtype and tumor site in under-20 year-olds. Methods. - A review of the literature on meningioma during the first 2 decades of life was carried out ...
  • PEREIRA, B. Jamilson Araujo; ALMEIDA, A. Nogueira de; PAIVA, W. Silva; AGUIAR, P. Henrique Pires de; TEIXEIRA, M. Jacobsen; MARIE, S. Kazue Nagahashi (MASSON EDITEUR, MOULINEAUX CEDEX 9, FRANCE, 2020)
    Purpose. - Review the published data on spinal meningioma (SM) to create a more comprehensive picture of its natural history. Methods. - A review of the published SM literature was carried out through a Medline search up ...
  • FELTRAN, Luciana S.; WATANABE, Andreia; GUARAGNA, Mara S.; MACHADO, Ivan C.; CASIMIRO, Fernanda M. S.; NEVES, Precil D. M. M.; PALMA, Lilian M.; VARELA, Patricia; VAISBICH, Maria H.; MARIE, Suely K. N.; FACINCANI, Inalda; PESQUERO, Joao B.; BELANGERO, Vera M. S.; SAMPSON, Matthew G.; NOGUEIRA, Paulo C. Koch; ONUCHIC, Luiz F. (ELSEVIER SCIENCE INC, NEW YORK, USA, 2020)
  • INUZUKA, Luciana Midori; MACEDO-SOUZA, Lucia Ines; DELLA-RIPA, Bruno; CABRAL, Katiane S. S.; MONTEIRO, Fabiola; KITAJIMA, Joao Paulo; GODOY, Luis Filipe de Souza; DELGADO, Daniel de Souza; KOK, Fernando; GARZON, Eliana (ELSEVIER, AMSTERDAM, NETHERLANDS, 2020)
    SCN3A was recently recognized as a gene associated with neurodevelopmental disorder and epilepsy. We present two additional patients with a novel de novo SCN3A pathogenic variant, and a review of all published cases of de ...
  • SOUZA-TALARICO, Juliana Nery de; ALVES, Andrea Regiani; BRUCKI, Sonia Maria Dozzi; NITRINI, Ricardo; LUPIEN, Sonia J.; SUCHECKI, Deborah (PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, ENGLAND, 2020)
    Alzheimer's disease (AD) patients show high cortisol levels suggesting that biological mediators of stress may play a role in the neurodegenerative process of cognitive disorders. However, there is no consensus as to whether ...
  • REZENDE, Angelo R. T.; PACHECO, Sandra P.; BRANCO, Sulamy C. C.; FERNANDES, Rosangela D. C.; BOLDRINI, Carla R.; DORIA FILHO, Ulysses; BAZAN, Paulo R.; AMARO JUNIOR, Edson; REED, Umbertina Conti; CASELLA, Erasmo Barbante (ASSOC ARQUIVOS NEURO- PSIQUIATRIA, SAO PAULO SP, BRAZIL, 2020)
    Objective: To compare the ways of evaluating arithmetic skills in Brazilian children with ADHD by combining three validated neuropsychological tests and determining whether they are sensitive to the methylphenidate treatment. ...
  • TOSCANO, Eliana Cristina de Brito; VIEIRA, Erica Leandro Marciano; PORTELA, Ana Carolina Diniz Carvalho; CALIARI, Marcelo Vidigal; BRANT, Joseane Aparecida Sousa; GIANNETTI, Alexandre Varella; SUEMOTO, Claudia Kimie; LEITE, Renata Elaine Paraizo; NITRINI, Ricardo; RACHID, Milene Alvarenga; TEIXEIRA, Antonio Lucio (ACADEMIC PRESS INC ELSEVIER SCIENCE, SAN DIEGO, USA, 2020)
    Hippocampal sclerosis (HS) is characterized by neuronal loss and gliosis. The intensity and distribution of these histopathological findings over the Cornu Ammonis (CA) subfields are important for the classification of HS ...
  • FORTINI, I.; AROUCA, E.M.G.; TENGAM, F.M.; NITRINI, R. (ELSEVIER B.V., 2019)
  • MONTEIRO, Fabiola P.; CURRY, Cynthia J.; HEVNER, Robert; ELLIOTT, Stephen; FISHER, Jamie H.; TUROCY, John; DOBYNS, William B.; COSTA, Larissa A.; FREITAS, Erika; KITAJIMA, Joao Paulo; KOK, Fernando (ELSEVIER, AMSTERDAM, NETHERLANDS, 2020)
    The Na+/K+ - ATPase acts as an ion pump maintaining the essential plasma membrane potential in all mammalian cell types, and is essential for many cellular functions. There are four a isoforms (alpha 1, alpha 2, alpha 3 ...
  • SALERNO, Gisela R. F.; BORTOLINI, Maria A. T.; GOMES, Regina C. T.; FEITOSA, Suellen M.; SIMOES, Manuel J.; ZANOTELI, Edmar; CASTANHO, Fernanda L.; CASTRO, Rodrigo A. (WILEY, HOBOKEN, USA, 2020)
    Aims To evaluate the expression of genes and proteins related to the urethral muscles of female rats after trauma by vaginal distention (VD) and after electrical stimulation therapy (EST). Methods We compared the urethras ...
  • POLIDO, Graziela Jorge; MIRANDA, Mariana Mangini Vaz de; CARVAS JUNIOR, Nelson; MENDONÇA, Rodrigo de Holanda; CAROMANO, Fátima Aparecida; REED, Umbertina Conti; ZANOTELI, Edmar; VOOS, Mariana Callil (Associação de Neurologia Cognitiva e do Comportamento, 2019)
    ABSTRACT Spinal muscular atrophy (SMA) is genetic and progressive, caused by large bi-allelic deletions in the SMN1 gene, or the association of a large deletion and a null variant. Objective: To evaluate the evidence about ...

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