LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

O Laboratório de Gastroenterologia e Clínica Experimental é ligado ao Departamento de Gastroenterologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: doenças inflamatórias, autoimunes e funcionais do intestino: genética, etiopatogenia, imunologia e epidemiologia, doença celíaca: imunologia e epidemiologia; quantificação do glúten em alimentos; nano partículas e micropartículas em processo inflamatório intestinal; modelos experimentais de colite; hepatites virais, cirroses e suas complicações e hepatopatias; doença hepática gordurosa; obesidade; estresse oxidativo e síndrome metabólica.

Site oficial: http://limhc.fm.usp.br/portal/lim07-laboratorio-de-gastroenterologia-clinica-e-experimental/

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Recent Submissions

  1. Detection of coronavirus-2 by real-time reverse transcription polymerase chain reaction in conjunctival swabs from patients with severe form of Coronavirus disease 2019 in Sao Paulo, Brazil

    CLINICS, v.76, article ID e2913, 6p, 2021

    OBJECTIVES: To test conjunctival swabs from patients with laboratory-confirmed severe forms of coronavirus disease 2019 (COVID-19) for the presence of SARS-CoV-2 on real-time reverse-transcription polymerase chain reaction (rRT-PCR). METHODS: Fifty conjunctival swabs were collected from 50 in-pat...

  2. The impact of hepatitis E infection on hepatic fibrosis in liver transplanted patients for hepatitis C infection

    BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.25, n.3, article ID 101587, 6p, 2021

    Hepatitis E Virus (HEV) is an infection known worldwide for its asymptomatic and self-limited course in most cases. Some cases progressing to chronicity have been described in immunosuppressed patients, especially in recipients of solid organ transplants. We evaluated laboratory parameters of HEV...

  3. Effects of intragastric balloon placement in metabolic dysfunction-associated fatty liver disease: A systematic review and meta-analysis

    WORLD JOURNAL OF HEPATOLOGY, v.13, n.7, p.815-829, 2021

    BACKGROUND Metabolic dysfunction-associated fatty liver disease corresponds to a clinical entity that affects liver function triggered by the accumulation of fat in the liver and is linked with metabolic dysregulation. AIM To evaluate the effects of the intragastric balloon (IGB) in patients with...

  4. Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data

    JOURNAL OF GASTROINTESTINAL CANCER, v.52, n.3, p.952-958, 2021

    Purpose Describe sociodemographic and clinical characteristics of patients with hepatocellular carcinoma (HCC) and establish their history in the Brazilian public health system. Methods Retrospective observational study was conducted using the database from the Department of Informatics of the Un...

  5. Moving Fast Toward Hepatitis B Virus Elimination

    ANTIVIRAL DRUG DISCOVERY AND DEVELOPMENT, v.1322, p.115-138, 2021

    Currently, there are two safe and effective therapeutic strategies for chronic hepatitis B treatment, namely, nucleoside analogs and interferon alpha (pegylated or non-pegylated). These treatments can control viral replication and improve survival; however, they do not eliminate the virus and the...

  6. Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data (vol, pg, )

    JOURNAL OF GASTROINTESTINAL CANCER, v.52, n.3, p.959-959, 2021

  7. NAFLD: Challenges and opportunities to address the public health problem in Latin America

    ANNALS OF HEPATOLOGY, v.24, article ID 100359, 5p, 2021

    Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions worldwide. Collectively, Latin American countries have some of the highest obesity rates in the world and the fastest-growing prevalence of type 2 diabetes mellitus (T2DM). Since obesity and T2DM are intrinsically linked w...

  8. Unexpected findings of hepatitis B and delta infection in northeastern Brazil: A public health alert

    ANNALS OF HEPATOLOGY, v.22, article ID 100272, 6p, 2021

    Introduction and objectives: Research has shown that hepatitis B (HBV) and Delta virus (HDV) are a worldwide public health problem. This study aims to estimate the prevalence rates of HBV and HDV infection in five municipalities of Maranhao, Northeastern Brazil. Materials and methods: A total sam...

  9. HIGHER VALUES IN LIVER ELASTOGRAPHY AND MELD SCORE ARE MORTALITY PREDICTORS ON LIVER TRANSPLANT WAITING LIST

    ABCD-ARQUIVOS BRASILEIROS DE CIRURGIA DIGESTIVA-BRAZILIAN ARCHIVES OF DIGESTIVE SURGERY, v.31, n.1, article ID e1360, 5p, 2018

    Background: Liver elastography have been reported in hepatocellular carcinoma (HCC) with higher values; however, it is unclear to identify morbimortality risk on liver transplantation waiting list. Aim: To assess liver stiffness, ultrasound and clinical findings in cirrhotic patients with and wit...

  10. An autopsy study of the spectrum of severe COVID-19 in children: From SARS to different phenotypes of MIS-C

    ECLINICALMEDICINE, v.35, article ID 100850, 13p, 2021

    Background: COVID-19 in children is usually mild or asymptomatic, but severe and fatal paediatric cases have been described. The pathology of COVID-19 in children is not known; the proposed pathogenesis for severe cases includes immune-mediated mechanisms or the direct effect of SARS-CoV-2 on tis...