LIM/07 - Laboratório de Gastroenterologia Clínica e Experimental

O Laboratório de Gastroenterologia e Clínica Experimental é ligado ao Departamento de Gastroenterologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: doenças inflamatórias, autoimunes e funcionais do intestino: genética, etiopatogenia, imunologia e epidemiologia, doença celíaca: imunologia e epidemiologia; quantificação do glúten em alimentos; nano partículas e micropartículas em processo inflamatório intestinal; modelos experimentais de colite; hepatites virais, cirroses e suas complicações e hepatopatias; doença hepática gordurosa; obesidade; estresse oxidativo e síndrome metabólica.

Site oficial: http://limhc.fm.usp.br/portal/lim07-laboratorio-de-gastroenterologia-clinica-e-experimental/

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Recent Submissions

  1. Evaluation of oxidative stress in an experimental model of Crohn's disease treated with hyperbaric oxygen therapy

    CLINICS, v.78, article ID 100305, 9p, 2023

    Introduction: Treatments of Inflammatory Bowel Disease (IBD) are able to control symptoms in most cases, how-ever, a fraction of patients do not improve or have a loss of response to treatments, making it important to explore new therapeutic strategies. Hyperbaric oxygen therapy (HBO) may represe...

  2. Neoadjuvant and adjuvant systemic treatment for hepatocellular carcinoma

    HEPATOMA RESEARCH, v.7, article ID 67, 12p, 2021

    Hepatocellular carcinoma (HCC) is a highly lethal malignancy, and few patients are candidates for curative-intended therapies. The mainstay of curative treatment in HCC is surgical resection, ablation, and transplantation. However, rates of recurrence are high, and there is no established approac...

  3. COVID-19 induces more pronounced extracellular matrix deposition than other causes of ARDS

    RESPIRATORY RESEARCH, v.24, n.1, article ID 281, 11p, 2023

    BackgroundLung fibrosis is a major concern in severe COVID-19 patients undergoing mechanical ventilation (MV). Lung fibrosis frequency in post-COVID syndrome is highly variable and even if the risk is proportionally small, many patients could be affected. However, there is still no data on lung e...

  4. Association of <i>UCP3</i> Polymorphisms with Nonalcoholic Steatohepatitis and Metabolic Syndrome in Nonalcoholic Fatty Liver Disease Brazilian Patients

    METABOLIC SYNDROME AND RELATED DISORDERS, v.20, n.2, p.114-123, 2022

    Background: We investigated the possible association of uncoupling protein 3 gene (UCP3) single nucleotide polymorphisms (SNPs) with nonalcoholic steatohepatitis (NASH) and metabolic syndrome (MetS) in nonalcoholic fatty liver disease (NAFLD) Brazilian patients.Methods: UCP3 SNPs rs1726745, rs378...

  5. AFP score and metroticket 2.0 perform similarly and could be used in a ""within-ALL"" clinical decision tool

    JHEP REPORTS, v.5, n.2, article ID 100644, 10p, 2023

    Background & Aims: Two recently developed composite models, the alpha-fetoprotein (AFP) score and Metroticket 2.0, could be used to select patients with hepatocellular carcinoma (HCC) who are candidates for liver transplantation (LT). The aim of this study was to compare the predictive performanc...

  6. Treatment Outcomes in Patients with Advanced Fibrolamellar Hepatocellular Carcinoma Under Systemic Treatment: Analysis of Clinical Characteristics, Management, and Radiomics

    JOURNAL OF HEPATOCELLULAR CARCINOMA, v.10, p.1923-1933, 2023

    Purpose: Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare primary liver malignancy often diagnosed at advanced stages. While there are limited data on the efficacy of specific agents, we aim to report outcomes of patients treated with systemic therapies and explore prognostic factors.Pati...

  7. P53 and VEGF are promising biomarkers for sorafenib efficacy in an experimental model of NASH-related HCC

    JOURNAL OF MOLECULAR HISTOLOGY, v.54, n.5, p.473-488, 2023

    The efficacy of systemic therapy for hepatocellular carcinoma (HCC) related to non-alcoholic steatohepatitis (NASH) is poorly understood. In this study we evaluated the effects of sorafenib based on the expression of molecular markers related to major hepatocarcinogenesis pathways and angiogenesi...

  8. Impact of radiotherapy on adverse events of self-expanding metallic stents in patients with esophageal cancer

    DISEASES OF THE ESOPHAGUS, v.36, n.10, 2023

    Self-expanding metallic stents (SEMS) are considered the treatment of choice for the palliation of dysphagia and fistulas in inoperable esophageal neoplasms. However, the safety of SEMSs in patients who received or who will be submitted to radiotherapy (RT) is uncertain. The study aimed to evalua...

  9. Low-volume direct strip multiplex PCR of intraocular fluid in uveitis

    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, v.64, n.8, article ID 613, 3p, 2023

  10. Strategies to eliminate hepatitis C virus infection in the Americas

    JOURNAL OF HEPATOLOGY, v.78, suppl.1, p.S900-S901, 2023