LIM/53 - Laboratório de Micologia

O Laboratório de Micologia é ligado ao Departamento de Dermatologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: imunopatogenia da paracoccidioidomicose humana; aplicação de modelos experimentais no estudo da imunidade celular e humoral em micoses sistêmicas; análise de polimorfismos e alterações gênicas de isolados fúngicos da coleção de culturas do LIM-53 e IMTSP/USP; padronização de técnicas moleculares no diagnóstico de infecções fúngicas sistêmicas e oportunistas.

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Recent Submissions

  1. Evaluation of IFN-gamma secretion after stimulation with C. neoformans and C. gattii antigens in individuals with frequent exposure to the fungus

    JOURNAL DE MYCOLOGIE MEDICALE, v.32, n.2, article ID 101230, 5p, 2022

    In this study we produced antigenic extracts from prototypical strains of C. neoformans (VNI-VNIV) and C. gattii (VGI-VGIV) and tested IFN-gamma secretion by Elispot. Antigens from the eight Cryptococcus molecular types (VNI -VNIV and VGI - VGIV) were obtained after capsule reduction. IFN-gamma s...

  2. Use of hydrochlorothiazide and risk of nonmelanoma skin cancer: a pilot study in the Brazilian population

    INTERNATIONAL JOURNAL OF DERMATOLOGY, v.61, n.6, p.E213-E214, 2022

  3. A neglected disease. Human sporotrichosis in a densely populated urban area in Sao Paulo, Brazil: clinical-epidemiological and therapeutic aspects

    BRAZILIAN JOURNAL OF MICROBIOLOGY, v.53, n.2, p.739-748, 2022

    Human sporotrichosis is caused by different Sporothrix species; however, Sporothrix brasiliensis is the main species, usually related to cat transmission in urban areas. A retrospective descriptive study was conducted at the Institute of Infectology Emilio Ribas from 2010 to 2018. Demography, cli...

  4. Considerations on Immunization and Immunosuppression of Patients With Autoimmune Blistering Diseases During COVID-19 Pandemic in Brazil: Case Report

    FRONTIERS IN MEDICINE, v.8, article ID 811562, 6p, 2022

    Autoimmune blistering diseases comprise a rare group of potentially life-threatening dermatoses. Management of autoimmune disorders poses a challenge in terms of achieving disease control and preventing adverse events. Treatment often requires an individualized approach considering disease severi...

  5. The influence of sample processing time on the performance of Microsporum canis cultures in cats

    VETERINARY DERMATOLOGY, v.33, n.2, p.113-+, 2022

    Background Fungal culture is widely used as a diagnostic tool for detecting dermatophytosis. However, the presence of fungal contaminants can influence the culture's performance and compromise the diagnosis. Objective To verify whether the sample processing time can affect the performance of fung...

  6. Immune-Mediated Necrotizing Myositis Presenting with Cutaneous Lesions


  7. A Brazilian Inter-Hospital Candidemia Outbreak Caused by Fluconazole-Resistant Candida parapsilosis in the COVID-19 Era

    JOURNAL OF FUNGI, v.8, n.2, article ID 100, 8p, 2022

    Horizontal transmission of fluconazole-resistant Candida parapsilosis (FRCP) through healthcare workers' hands has contributed to the occurrence of candidemia outbreaks worldwide. Since the first COVID-19 case in Brazil was detected in early 2020, hospitals have reinforced hand hygiene and disinf...

  8. Immunology of leprosy

    INTERNATIONAL REVIEWS OF IMMUNOLOGY, v.41, n.2, p.72-83, 2022

    Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical manifestations, which are strongly correlated with the host's immune response. Skin lesions may be accompanied by peripheral neural damage, leading to sensory and motor losses, as well as deformities of the hands and f...

  9. Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults

    IMMUNITY & AGEING, v.19, n.1, article ID 9, 16p, 2022

    Background COPD is associated with an abnormal lung immune response that leads to tissue damage and remodeling of the lung, but also to systemic effects that compromise immune responses. Cigarette smoking also impacts on innate and adaptative immune responses, exerting dual, pro- and anti-inflamm...

  10. A 12-month follow-up split-scalp study comparing calcipotriol-assisted MAL-PDT with conventional MAL-PDT for the treatment of actinic keratosis: a randomized controlled trial

    EUROPEAN JOURNAL OF DERMATOLOGY, v.31, n.5, p.638-644, 2021

    Background To enhance the efficacy of photodynamic therapy (PDT) for actinic keratosis (AKs), physical and chemical pre-treatments, such as calcipotriol (CAL) have been suggested. Objectives To compare the long-term 12-month efficacy and safety between methylaminolevulinate (MAL)-PDT and prior ap...