LIM/53 - Laboratório de Micologia

O Laboratório de Micologia é ligado ao Departamento de Dermatologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: imunopatogenia da paracoccidioidomicose humana; aplicação de modelos experimentais no estudo da imunidade celular e humoral em micoses sistêmicas; análise de polimorfismos e alterações gênicas de isolados fúngicos da coleção de culturas do LIM-53 e IMTSP/USP; padronização de técnicas moleculares no diagnóstico de infecções fúngicas sistêmicas e oportunistas.

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Recent Submissions

  1. Antibody- Based Immunotherapy Combined With Antimycotic Drug TMP- SMX to Treat Infection With Paracoccidioides brasiliensis

    FRONTIERS IN IMMUNOLOGY, v.12, article ID 725882, 12p, 2021

    Monoclonal antibodies (mAbs) are promising alternatives to treat infectious diseases, especially given their potential for applications in combination therapies with antimicrobial drugs to enhance the antifungal efficacy. Protection mediated by mAbs used to treat experimental paracoccidioidomycos...

  2. Taxane-induced scleroderma. Report of two cases

    REVISTA MéDICA DE CHILE, v.149, n.5, p.807-809, 2021

    ABSTRACT Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have bee...

  3. Autoimmune bullous diseases in pregnancy: clinical and epidemiological characteristics and therapeutic approach

    ANAIS BRASILEIROS DE DERMATOLOGIA, v.96, n.5, p.581-590, 2021

    Autoimmune bullous dermatoses are a heterogeneous group of diseases with autoantibodies against structural skin proteins. Although the occurrence of autoimmune bullous dermatoses during pregnancy is low, this topic deserves attention, since the immunological and hormonal alterations that occur du...

  4. A Case-Control Study of Paracoccidioidomycosis in Women: The Hormonal Protection Revisited

    JOURNAL OF FUNGI, v.7, n.8, article ID 655, 15p, 2021

    Clinical observations have long suggested that women are protected against paracoccidioidomycosis. 17 beta-estradiol, the main female estrogen, inhibits conidia-to-yeast transformation (C-to-Y), which is required for the infection establishment. However, experiments in murine models have yielded ...

  5. How Coronavirus Disease 2019 Changed Dermatology Practice in 1 Year Around the World from 11 Countries

    DERMATOLOGIC CLINICS, v.39, n.4, p.639-651, 2021

  6. Neutrophil Cells Are Essential for The Efficacy of a Therapeutic Vaccine against Paracoccidioidomycosis

    JOURNAL OF FUNGI, v.7, n.6, article ID 416, 10p, 2021

    Paracoccidioidomycosis (PCM), caused by the Paracoccidioides species, is a systemic disease endemic in several Latin American countries, mainly in Brazil, Colombia, Argentina, and Venezuela. Current treatment approaches are challenging as they require prolonged durations of antifungal drugs that ...

  7. Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned from Candida albicans-In Silico, In Vitro and In Vivo Approaches

    JOURNAL OF FUNGI, v.7, n.6, article ID 424, 33p, 2021

    The repurposing strategy was applied herein to evaluate the effects of lopinavir, an aspartic protease inhibitor currently used in the treatment of HIV-infected individuals, on the globally widespread opportunistic human fungal pathogen Candida albicans by using in silico, in vitro and in vivo ap...

  8. Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of Sao Paulo State, Brazil

    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, v.54, n.9, article ID e10928, 5p, 2021

    This study aimed to evaluate the frequency of cryptic Candida species from candidemia cases in 22 public hospitals in Sao Paulo State, Brazil, and their antifungal susceptibility profiles. During 2017 and 2018, 144 isolates were molecularly identified as 14 species; C. parapsilosis (32.6%), C. al...

  9. Clear Cell Porocarcinoma Arising in an Epidermodysplasia Verruciformis Patient


  10. Inter- and intra-patient heterogeneity of PD-L1 expression in metastatic melanomas: A retrospective study

    AUSTRALASIAN JOURNAL OF DERMATOLOGY, v.62, n.2, p.227-229, 2021