LIM/31 - Laboratório de Genética e Hematologia Molecular

O Laboratório de Genética e Hematologia Molecular é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: Genética e hematologia molecular; terapia celular e gênica; onco-hematologia; hemostasia; metabolismo lipídico.

Site oficial:


Recent Submissions

  1. Suggested guidelines for convalescent plasma therapy for the treatment of COVID-19

    HEMATOLOGY TRANSFUSION AND CELL THERAPY, v.43, n.2, p.212-213, 2021

  2. Imunoterapia: conceito, principais abordagens clínicas, vantagens e desvantagens

    Assis, Nadine Gimenez de; Tessarollo, Nayara Gusmão; Barbuto, José Alexandre Marzagão. Imunoterapia: conceito, principais abordagens clínicas, vantagens e desvantagens. In: Chammas, Roger; Folgueira, Maria Aparecida Koike; Villa, Luisa Lina (eds). Oncologia - da molécula à clínica. SÃO PAULO: Editora dos Editores, 2022. p.447-487.

  3. Risk of liver and non-liver-related mortality among hepatitis C virus and human immunodeficiency virus co-infected persons in a cohort of Brazilian blood donors: a twenty-year study

    JOURNAL OF HEPATOLOGY, v.73, suppl.1, p.S315-S315, 2020

  4. The War Is on: The Immune System against Glioblastoma-How Can NK Cells Drive This Battle?

    BIOMEDICINES, v.10, n.2, article ID 400, 41p, 2022

    Natural killer (NK) cells are innate lymphocytes that play an important role in immuno-surveillance, acting alongside other immune cells in the response against various types of malignant tumors and the prevention of metastasis. Since their discovery in the 1970s, they have been thoroughly studie...

  5. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) and esophageal rupture by candida infection: A case report and review

    JOURNAL DE MYCOLOGIE MEDICALE, v.32, n.3, article ID 101293, 3p, 2022

    We probably describe the first report of esophageal rupture in a patient with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED, OMIM # 240300), who had candida esophagitis as the main feature for decades. Strong evidence shows that this rupture may have been caused directly ...

  6. Diagnosis, treatment and maxillofacial rehabilitation in rhinocerebral mucormycosis patient: A case report and review of the literature

    JOURNAL DE MYCOLOGIE MEDICALE, v.32, n.1, article ID 101211, 7p, 2022

    Mucormycosis is an aggressive, rare and opportunistic infectious disease, with a high mortality rate. Etiologic agents are filamentous fungi, and infection among humans normally occurs through spore inhalation. A 61-year-old male individual, presenting left eye amaurosis, dark epistaxis, hyperalg...

  7. Near-Complete Remission of Glioblastoma in a Patient Treated with an Allogenic Dendritic Cell-Based Vaccine: The Role of Tumor-Specific CD4+T-Cell Cytokine Secretion Pattern in Predicting Response and Recurrence

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, n.10, article ID 5396, 10p, 2022

    Immunotherapy has brought hope to the fight against glioblastoma, but its efficacy remains unclear. We present the case of CST, a 25-year-old female patient with a large right-hemisphere glioblastoma treated with a dendritic-tumor cell fusion vaccine. CST showed a near-complete tumor response, wi...

  8. Diagnostic and prognostic implications of tumor expression of the GATA-3 gene in nodal peripheral T-cell lymphoma (nPTCL): Retrospective data from a Latin American cohort

    LEUKEMIA RESEARCH, v.114, article ID 106794, 9p, 2022

    Background: Nodal peripheral T-cell lymphomas (nPTCL) encompass a heterogeneous group of mature and aggressive lymphoid malignancies, including peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), angioimmunoblastic T-cell lymphoma (AITL) and anaplastic large cell lymphoma (ALCL) ALK-...

  9. Unraveling the Genetic Architecture of Hepatoblastoma Risk: Birth Defects and Increased Burden of Germline Damaging Variants in Gastrointestinal/Renal Cancer Predisposition and DNA Repair Genes

    FRONTIERS IN GENETICS, v.13, article ID 858396, 17p, 2022

    The ultrarare hepatoblastoma (HB) is the most common pediatric liver cancer. HB risk is related to a few rare syndromes, and the molecular bases remain elusive for most cases. We investigated the burden of rare damaging germline variants in 30 Brazilian patients with HB and the presence of additi...

  10. The Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P): A research program striving to improve blood donor safety and optimize transfusion outcomes across the lifespan

    TRANSFUSION, v.62, n.5, p.982-999, 2022

    Background The Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) is a new iteration of prior National Heart, Lung, and Blood Institute (NHLBI) REDS programs that focus on improving transfusion recipient outcomes across the lifespan as well as the safety and availability o...