LIM/14 - Laboratório de Investigação em Patologia Hepática

LIM/14 - Laboratório de Investigação em Patologia Hepática

 

O Laboratório de Investigação em Patologia Hepática é ligado ao Departamento de Patologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: patologia hepática, com ênfase na patogênese da evolução para formas mais graves de cirrose e para carcinoma hepatocelular; caracterização de anticorpos para estudos imuno-histoquímicos com ênfase em neoplasias digestivas, ginecológicas e condições obstétricas, neuropatologia.

Site oficial: http://limhc.fm.usp.br/portal/lim14-laboratorio-de-investigacao-em-patologia-hepatica/

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Recent Submissions

  • CASTRO, Joana Vieira de; GONCALVES, Celine S.; MARTINS, Eduarda P.; MIRANDA-LORENZO, Irene; CERQUEIRA, Mariana T.; LONGATTO-FILHO, Adhemar; PINTO, Afonso A.; REIS, Rui L.; SOUSA, Nuno; HEESCHEN, Christopher; COSTA, Bruno M. (MDPI, BASEL, SWITZERLAND, 2021)
    Simple Summary Since glioblastoma stem cells (GSCs) have paramount roles in tumor initiation, progression, recurrence, and therapy resistance, innovative approaches to specifically identify and isolate GSCs in a straightforward ...
  • RAMOS, Marcus Fernando Kodama P.; PEREIRA, Marina Alessandra; CASTRIA, Tiago Biachi; RIBEIRO, Renan Ribeiro e; MELLO, Evandro Sobroza; DIAS, Andre Roncon; ZILBERSTEIN, Bruno; RIBEIRO JR., Ulysses; CECCONELLO, Ivan (ELSEVIER SCIENCE INC, NEW YORK, USA, 2020)
  • PEREIRA, Marina A.; RAMOS, Marcus Fernando Kodama P.; RIBEIRO, Renan Ribeiro e; DIAS, Andre R.; RIBEIRO JR., Ulysses; ZILBERSTEIN, Bruno; CECCONELLO, Ivan; MELLO, Evandro Sobroza; CASTRIA, Tiago B. (ELSEVIER SCIENCE INC, NEW YORK, USA, 2020)
  • PIQUE-GILI, Marta; PINYOL, Roser; TORRECILLA, Sara; WANG, Huan; MONTIRONI, Carla; RAMADORI, Pierluigi; WILLOUGHBY, Catherine E.; ANDREU-OLLER, Carmen; TORRES-MARTIN, Miguel; LEOW, Wei-Qiang; MOEINI, Agrin; TAIK, Patricia; GALLOFRE, Judit Peix; OLIVEIRA, Claudia P. M. S.; ALVES, Venancio A. F.; LACHENMAYER, Anja; ROESSLER, Stephanie; MINGUEZ, Beatriz; SCHIRMACHER, Peter; BOFFETTA, Paolo; DUFOUR, Jean-Francois; THUNG, Swan N.; REEVES, Helen; UZILOV, Andrew; CARRILHO, Flair J.; CHANG, Charissa Y.; HEIKENWAELDER, Mathias; SANYAL, Arun J.; FRIEDMAN, Scott L.; SIA, Daniela; LLOVET, Josep M. (WILEY, HOBOKEN, USA, 2020)
  • DIAS, Tauana Christina; LONGATTO-FILHO, Adhemar; CAMPANELLA, Nathalia C. (FUTURE SCI LTD, LONDON, ENGLAND, 2020)
    The biological importance of human papillomavirus (HPV) in the field of medicine - related to cervical carcinogenesis - has been extensively reported in the last decades. For the first time, a direct correlation between ...
  • PEIXOTO, Renata D'Alpino; ROCHA-FILHO, Duilio R.; WESCHENFELDER, Rui F.; REGO, Juliana F. M.; RIECHELMANN, Rachel; COUTINHO, Anelisa K.; FERNANDES, Gustavo S.; JACOME, Alexandre A.; ANDRADE, Aline C.; MURAD, Andre M.; MELLO, Celso A. L.; MIGUEL, Diego S. C. G.; GOMES, Diogo B. D.; RACY, Douglas J.; MORAES, Eduardo D.; AKAISHI, Eduardo H.; CARVALHO, Elisangela S.; MELLO, Evandro S.; MALUF FILHO, Fauze; COIMBRA, Felipe J. F.; CAPARELI, Fernanda C.; ARRUDA, Fernando F.; VIEIRA, Fernando M. A. C.; TAKEDA, Flavio R.; COTTI, Guilherme C. C.; PEREIRA, Guilherme L. S.; PAULO, Gustavo A.; RIBEIRO, Heber S. C.; LOURENCO, Laercio G.; CROSARA, Marcela; TONETO, Marcelo G.; OLIVEIRA, Marcos B.; OLIVEIRA, Maria de Lourdes; BEGNAMI, Maria Dirlei; FORONES, Nora M.; YAGI, Osmar; ASHTON-PROLLA, Patricia; AGUILLAR, Patricia B.; AMARAL, Paulo C. G.; HOFF, Paulo M.; ARAUJO, Raphael L. C.; PAULA FILHO, Raphael P. Di; GANSL, Rene C.; GIL, Roberto A.; PFIFFER, Tulio E. F.; SOUZA, Tulio; JR, Ulysses Ribeiro; JESUS, Victor Hugo F.; JR, Wilson L. Costa; PROLLA, Gabriel (CANCER INTELLIGENCE LTD, BRISTOL, ENGLAND, 2020)
    Gastric cancer is among the ten most common types of cancer worldwide. Most cases and deaths related to the disease occur in developing countries. Local socio-economic, epidemiologic and healthcare particularities led us ...
  • CARVALHO, Joao Paulo Mancusi de; SALIM, Rafael C.; CARVALHO, Filomena Marino; GENTA, Maria Luiza Nogueira Dias; BARACAT, Edmund Chada; CARVALHO, Jesus Paula (BMJ PUBLISHING GROUP, LONDON, ENGLAND, 2020)
    Aims L1 cell adhesion molecule (L1CAM) has been shown to be correlated with tumour progression, attributed to its possible association with epithelial-mesenchymal transition (EMT), characterised by the expression of vimentin ...
  • SANTANA, Nathalie Oliveira; LERARIO, Antonio Marcondes; SCHMERLING, Claudia Kliemann; MARUI, Suemi; ALVES, Venancio Avancini Ferreira; HOFF, Ana O.; KOPP, Peter; DANILOVIC, Debora Lucia Seguro (BIOSCIENTIFICA LTD, BRISTOL, ENGLAND, 2020)
    Objective: Genomic alterations in Hurthle cell carcinomas (HCC) include chromosomal losses, mitochondria! DNA mutations, and changes in the expression profile of the PI3K-AKT-mTOR and Wnt/beta-catenin pathways. This study ...
  • GOUVEIA, Gisele R.; FERREIRA, Suzete C.; SIQUEIRA, Sheila A. C.; LAGE, Luis Alberto de Padua Covas; HALLACK NETO, Abrahao E.; COSTA, Renata de Oliveira; PEREIRA, Juliana (BMC, LONDON, ENGLAND, 2020)
    BackgroundOCT-1 gene is a member of the POU-homeodomain family of transcriptional regulators of B-lymphocyte differentiation by controlling expression of B-cell specific genes. BCL-2 gene is a potent inhibitor of apoptosis ...
  • PEREHUDOFF, Katrina; VERMANDERE, Heleen; WILLIAMS, Alex; BAUTISTA-ARREDONDO, Sergio; PAEPE, Elien De; DIAS, Sonia; GAMA, Ana; KEYGNAERT, Ines; LONGATTO-FILHO, Adhemar; ORTIZ, Jose; PADALKO, Elizaveta; REIS, Rui Manuel; VANDERHEIJDEN, Nathalie; VEGA, Bernardo; VERBERCKMOES, Bo; DEGOMME, Olivier (BMC, LONDON, ENGLAND, 2020)
    Background Cervical cancer claims 311,000 lives annually, and 90% of these deaths occur in low- and middle-income countries. Cervical cancer is a highly preventable and treatable disease, if detected through screening at ...
  • WEIGAND, Isabel; ALTIERI, Barbara; LACOMBE, Amanda M. F.; BASILE, Vittoria; KIRCHER, Stefan; LANDWEHR, Laura-Sophie; SCHREINER, Jochen; ZERBINI, Maria C. N.; RONCHI, Cristina L.; MEGERLE, Felix; BERRUTI, Alfredo; CANU, Letizia; VOLANTE, Marco; PAIVA, Isabel; CASA, Silvia Della; SBIERA, Silviu; FASSNACHT, Martin; V, Maria Candida B. Fragoso; TERZOLO, Massimo; KROISS, Matthias (ENDOCRINE SOC, WASHINGTON, USA, 2020)
    Context: Objective response rate to mitotane in advanced adrenocortical carcinoma (ACC) is approximately 20%, and adverse drug effects are frequent. To date, there is no marker established that predicts treatment response. ...
  • SANDUZZI-ZAMPARELLI, Marco; RIMOLA, Jordi; MONTIRONI, Carla; NUNES, Vinicius; ALVES, Venancio Avancini Ferreira; SAPENA, Victor; FONSECA, Leonardo Gomes da; FORNER, Alejandro; CARRILHO, Flair Jose; DIAZ, Alba; FUSTER, Carla; FERRER, Joana; FUSTER, Josep; AYUSO, Carmen; SOLE, Manel; BRUIX, Jordi; REIG, Maria (ELSEVIER SCIENCE INC, NEW YORK, USA, 2020)
    Background and aims: Hepatic epithelioid hemangioendothelioma is an ultra-rare hepatic vascular tumor, diagnosed more frequently in females. The knowledge about this tumor derives mainly from small case series with sub-optimal ...
  • SANDRI, Silvana; WATANABE, Luis R. M.; OLIVEIRA, Erica Aparecida de; FAIAO-FLORES, Fernanda; MIGLIORINI, Silene; TIAGO, Manoela; FELIPE-SILVA, Aloisio; VAZQUEZ, Vinicius de Lima; SOUZA, Paola da Costa; CONSOLARO, Marcia Edilaine Lopes; CAMPA, Ana; MARIA-ENGLER, Silvya Stuchi (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, LONDON, ENGLAND, 2020)
    Indoleamine 2,3-dioxygenase (IDO) is associated with the progression of many types of tumors, including melanoma. However, there is limited information about IDO modulation on tumor cell itself and the effect of BRAF ...
  • BERTONHA, F. B.; BANDO, S. Y.; FERREIRA, L. R.; CHACCUR, P.; VINHAS, C.; ZERBINI, M. C. N. (PUBLIC LIBRARY SCIENCE, SAN FRANCISCO, USA, 2020)
  • CONCEICAO, Barbara Brito da; CAVALCANTE, Isadora Pontes; KREMER, Jean Lucas; AURICINO, Thais Barabba; BENTO, Eduarda Correa; ZERBINI, Maria Claudia Nogueira; FRAGOSO, Maria Candida Barisson Villares; LOTFI, Claudimara Ferini Pacicco (SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA, RIO DE JANEIRO, RJ, BRAZIL, 2020)
    Objective. To analyze the morphological and functional characteristics of primary macronodular adrenal hyperplasia (PMAH) nodules carrying or not carrying ARMC5 mutations and the consequences of the presence of mutations ...
  • TANNO, Fabio Yoshiaki; SROUGI, Victor; ALMEIDA, Madson Q.; YAMAUCHI, Fernando Ide; COELHO, Fernando Morbeck Almeida; NISHI, Mirian Yumie; ZERBINI, Maria Claudia Nogueira; SOARES, Iracy Silvia Correa; PEREIRA, Maria Adelaide Albergaria; CHARCHAR, Helaine Laiz Silva; LACOMBE, Amanda Meneses Ferreira; BRONDANI, Vania Balderrama; SROUGI, Miguel; NAHAS, Willian Carlos; MENDONCA, Berenice B.; CHAMBO, Jose Luis; FRAGOSO, Maria Candida Barisson Villares (ENDOCRINE SOC, WASHINGTON, USA, 2020)
    Purpose: This prospective study presents the results of a new approach in the treatment of primary macronodular adrenal hyperplasia (PMAII), with simultaneous total adrenalectomy of the larger adrenal gland and partial ...
  • CALEIA, Ana Isabel; PIRES, Catarina; PEREIRA, Jacinta de Fatima; PINTO-RIBEIRO, Filipa; LONGATTO-FILHO, Adhemar (KARGER, BASEL, SWITZERLAND, 2020)
    Background:Cervical cancer is the fourth most common cancer in the world. A raised incidence and mortality parallel a low participation rate in screening, namely screening in poor countries and among specific populations ...
  • OLIVEIRA, Cristina Mendes de; MUSSELWHITE, Laura W.; PANTANO, Naitielle de Paula; VAZQUEZ, Fabiana Lima; SMITH, Jennifer S.; SCHWEIZER, Johannes; BELMARES, Michael; POSSATI-RESENDE, Julio Cesar; VIEIRA, Marcelo de Andrade; LONGATTO-FILHO, Adhemar; FREGNANI, Jose Humberto Tavares Guerreiro (PUBLIC LIBRARY SCIENCE, SAN FRANCISCO, USA, 2020)
    Cervical cancer is a significant public health problem, especially in low- and middle-income countries, where women have little access to cervical cancer screening; consequently 80% of cervical cancer related mortality ...
  • ALVES-FERNANDES, Debora Kristina; OLIVEIRA, Erica Aparecida de; HASTREITER, Araceli Aparecida; FAIAO-FLORES, Fernanda; FELIPE-SILVA, Aloisio Souza; TURATO, Walter; FOCK, Ricardo Ambrosio; MARIA-ENGLER, Silvya Stuchi; BARROS, Silvia Berlanga de Moraes (PERGAMON-ELSEVIER SCIENCE LTD, OXFORD, ENGLAND, 2020)
    NRAS-mutations arise in 15-20% of all melanomas and are associated with aggressive disease and poor prognosis. Besides, the treatment for NRAS-mutant melanoma are not very efficient and is currently limited to immune ...

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