LIM/13 - Laboratório de Genética e Cardiologia Molecular
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Reciprocal regulation of endothelial-mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease
SCIENTIFIC REPORTS, v.11, n.1, article ID 17764, 16p, 2021
Endothelial-mesenchymal transition (EndMT) is a form of endothelial dysfunction wherein endothelial cells acquire a mesenchymal phenotype and lose endothelial functions, which contributes to the pathogenesis of intimal hyperplasia and atherosclerosis. The mitogen activated protein kinase 7 (MAPK7...
Compared Heritability of Chronotype Instruments in a Single Population Sample
JOURNAL OF BIOLOGICAL RHYTHMS, v.36, n.5, p.483-490, 2021
It is well established that the oldest chronotype questionnaire, the morningness-eveningness questionnaire (MEQ), has significant heritability, and several associations have been reported between MEQ score and polymorphisms in candidate clock genes, a number of them reproducibly across population...
A Sodium Oxalate-Rich Diet Induces Chronic Kidney Disease and Cardiac Dysfunction in Rats
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.17, article ID 9244, 13p, 2021
Chronic kidney disease (CKD) is a worldwide public health issue affecting 14% of the general population. However, research focusing on CKD mechanisms/treatment is limited because of a lack of animal models recapitulating the disease physiopathology, including its complications. We analyzed the ef...
Dynamic Crosstalk between Vascular Smooth Muscle Cells and the Aged Extracellular Matrix
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, n.18, article ID 10175, 17p, 2021
Vascular aging is accompanied by the fragmentation of elastic fibers and collagen deposition, leading to reduced distensibility and increased vascular stiffness. A rigid artery facilitates elastin to degradation by MMPs, exposing vascular cells to greater mechanical stress and triggering signalin...
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
LANCET, v.398, n.10304, p.957-980, 2021
Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Meth...
Atrial Fibrillation Diagnosis using ECG Records and Self-Report in the Community: Cross-Sectional Analysis from ELSA-Brasil
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.117, n.3, p.426-434, 2021
Background: Atrial fibrillation or flutter (AFF) is the most common sustained cardiac arrhythmia. Limited data can be found on All epidemiology in South America. Objective: The present study sought to describe the clinical epidemiology of AFF and the use of stroke prevention medication in the Bra...
Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients
SCIENTIFIC REPORTS, v.11, n.1, article ID 15223, 12p, 2021
The role of innate immunity in COVID-19 is not completely understood. Therefore, this study explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on the expression of Pattern Recognition Receptors (PRRs) in peripheral blood cells and their correlated cytoki...
Marcatto, Leiliane Rodrigues; Tavares, Letícia Camargo; Sacilotto, Luciana; Santos, Paulo Caleb Júnior de Lima. Fármacos anticoagulantes. In: Santos, Paulo Caleb Júnior de Lima; Girardi, Adriana Castello Costa; Cruz, Fábio Cardoso; Pereira, Gustavo José da Silva (eds). Litro-texto farmacologia. RIO DE JANEIRO: Atheneu, 2021. p.543-554.
Fármacos utilizados no tratamento da isquemia miocárdica
Borges, Lígia Sayuri Teoi Coelho; Borges Júnior, Flávio Araújo. Fármacos utilizados no tratamento da isquemia miocárdica. In: Santos, Paulo Caleb Júnior de Lima; Girardi, Adriana Castello Costa; Cruz, Fábio Cardoso; Pereira, Gustavo José da Silva (eds). Litro-texto farmacologia. RIO DE JANEIRO: Atheneu, 2021. p.425-443.
Marcatto, Leiliane Rodrigues; Pessente, Gabrielle D'Arezzo; Sacilotto, Luciana. Fármacos antiarrítmicos. In: Santos, Paulo Caleb Júnior de Lima; Girardi, Adriana Castello Costa; Cruz, Fábio Cardoso; Pereira, Gustavo José da Silva (eds). Litro-texto farmacologia. RIO DE JANEIRO: Atheneu, 2021. p.457-468.