LIM/13 - Laboratório de Genética e Cardiologia Molecular

O Laboratório de Genética e Cardiologia Molecular é ligado ao Departamento de Cardiopneumologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: identificação e caracterização de biomarcadores para utilização em algoritmos de apoio à decisão médica; desenvolvimento de estratégias para reparação de órgãos com baixa capacidade regenerativa; genética das doenças cardiovasculares; evolução das câmaras cardíacas; biologia do desenvolvimento do coração; cardiopatias congênitas; sinalização pelo ácido retinoico; desenvolvimento de vetores virais portadores de genes supressores de tumor e imunoestimuladores para terapia gênica do câncer.

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Recent Submissions


    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v.79, n.9, suppl.S, p.1472-1472, 2022

  2. Transcriptome Analysis of Elderly Women with Low Muscle Mass Reveals an Association with Immune System Pathway

    JOURNAL OF BONE AND MINERAL RESEARCH, v.37, suppl.1, p.205-205, 2022

  3. Subjective sleep quality before and during the COVID-19 pandemic in a Brazilian rural population

    SLEEP HEALTH, v.8, n.2, p.167-174, 2022

    Objectives: Prior studies have examined sleep during the coronavirus disease 2019 (COVID-19) pandemic, but have few compared sleep measured both during and prior to COVID. We examined the impact of the COVID-19 pandemic on subjective sleep quality in general and separately by gender and age (<50 ...

  4. The Clinical Genome Resource (ClinGen) Familial Hypercholesterolemia Variant Curation Expert Panel consensus guidelines for LDLR variant classification

    GENETICS IN MEDICINE, v.24, n.2, p.293-306, 2022

    Purpose: In 2015, the American College of Medical Genetics and Genomics (ACMG) and the Association for Molecular Pathology (AMP) published consensus standardized guidelines for sequence-level variant classification in Mendelian disorders. To increase accuracy and consistency, the Clinical Genome ...

  5. Physical exercise attenuates obesity development in Western-diet fed obese rats independently of vitamin D supplementation


    Physical inactivity, associated with the ingestion of hypercaloric foods, contributes to obesity development. In contrast, physical exercise training (ET) can slow obesity progression. Vitamin (Vit) D, a hormone that regulates adipocyte metabolism, may represent a strategy to reduce obesity; howe...

  6. Clinical, Laboratory, and Imaging Profile in Patients with Systemic Amyloidosis in a Brazilian Cardiology Referral Center

    ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.118, n.2, p.422-431, 2022

    Background: Systemic amyloidosis is a disease with heterogeneous clinical manifestations. Diagnosis depends on clinical suspicion combined with specific complementary methods. Objective: To describe the clinical, laboratory, electrocardiographic, and imaging profile in patients with systemic amyl...

  7. Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium

    HUMAN GENETICS AND GENOMICS ADVANCES, v.3, n.2, article ID 100099, 21p, 2022

    Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite their notable anthropometric variability, ancestry proportions, and high burden of growth stunting and overweight/obesity. To address this knowledge gap, we analyzed densely imp...

  8. Mapping the human genetic architecture of COVID-19

    NATURE, v.600, n.7889, p.472-+, 2021

    The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19(1,2), host genetics may also be important. Identifying host-...

  9. Blockchain-Based Architecture Design for Personal Health Record: Development and Usability Study

    JOURNAL OF MEDICAL INTERNET RESEARCH, v.24, n.4, article ID e35013, 16p, 2022

    Background: The importance of blockchain-based architectures for personal health record (PHR) lies in the fact that they are thought and developed to allow patients to control and at least partly collect their health data. Ideally, these systems should provide the full control of such data to the...

  10. The fungicide Tebuconazole induces electromechanical cardiotoxicity in murine heart and human cardiomyocytes derived from induced pluripotent stem cells

    TOXICOLOGY LETTERS, v.359, p.96-105, 2022

    Tebuconazole (TEB) is an important fungicide that belongs to the triazole family. It is widely used in agriculture and its use has experienced a tremendous increase in the last decade. The long-term exposure of humans to this pesticide is a real threat because it is stable in water and soil. The ...