LIM/43 - Laboratório de Medicina Nuclear

URI Permanente desta comunidade

O Laboratório de Medicina Nuclear é ligado ao Departamento de Radiologia e Oncologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: análise crítica dos métodos de neuroimagem funcional na avaliação das desordens neurológicas e psiquiátricas; medicina nuclear e aplicação clínica dos radioisótopos.

Site oficial: http://limhc.fm.usp.br/portal/lim43-laboratorio-de-medicina-nuclear/

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Scopus: 35

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Coleções desta Comunidade

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article 7 Citação(ões) na Scopus
Locking and Unlocking Thrombin Function Using Immunoquiescent Nucleic Acid Nanoparticles with Regulated Retention In Vivo
(2022) KE, W.; CHANDLER, M.; CEDRONE, E.; SAITO, R. F.; RANGEL, M. C.; JUNQUEIRA, M. De Souza; WANG, J.; SHI, D.; TRUONG, N.; RICHARDSON, M.; ROLBAND, L. A.; DRéAU, D.; BEDOCS, P.; CHAMMAS, R.; DOKHOLYAN, N. V.; DOBROVOLSKAIA, M. A.; AFONIN, K. A.
The unbalanced coagulation of blood is a life-threatening event that requires accurate and timely treatment. We introduce a user-friendly biomolecular platform based on modular RNA-DNA anticoagulant fibers programmed for reversible extracellular communication with thrombin and subsequent control of anticoagulation via a ""kill-switch""mechanism that restores hemostasis. To demonstrate the potential of this reconfigurable technology, we designed and tested a set of anticoagulant fibers that carry different thrombin-binding aptamers. All fibers are immunoquiescent, as confirmed in freshly collected human peripheral blood mononuclear cells. To assess interindividual variability, the anticoagulation is confirmed in the blood of human donors from the U.S. and Brazil. The anticoagulant fibers reveal superior anticoagulant activity and prolonged renal clearance in vivo in comparison to free aptamers. Finally, we confirm the efficacy of the ""kill-switch""mechanism in vivo in murine and porcine models.
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Generating PET-derived maps of myelin content from clinical MRI using Generative Adversarial Networks
(2023) SOULIER, Theodore; HAMZAOUI, Mariem; PITOMBEIRA, Milena Sales; FARIA, Daniele; YAZDAN-PANAH, Arya; TONIETTO, Matteo; BOTTLAENDER, Michel; LEROY, Claire; BODINI, Benedetta; AYACHE, Nicholas; COLLIOT, Olivier; STANKOFF, Bruno
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Metabolic and Structural Signatures in Corticobasal Syndrome: A Multimodal PET/MRI Study
(2021) CARNEIRO, G. C.; PARMERA, J. B.; ALMEIDA, I. J.; OLIVEIRA, M. C. B.; SILAGI, M. L.; STUDART-NETO, A.; ONO, C. R.; BARBOSA, E. R.; NITRINI, R.; BUCHPIGUEL, C. A.; BRUCKI, S. M. D.; COUTINHO, A. M.
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Comparative analysis of image quality parameters in three PET systems in Brazil
(2021) GONTIJO, Rodrigo Modesto Gadelha; FERREIRA, Andrea Vidal; FARIA, Daniele de Paula; BUCHPIGUEL, Carlos Alberto; GREGGIO, Samuel; VENTURIN, Gianina Teribele; COSTA, Jaderson Costa da; SILVA, Juliana Batista da; MAMEDE, Marcelo
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Effects of sulforaphane association to conventional therapy for treating triple-negative breast cancer
(2023) COUTINHO, L. L.; CHENG, R.; RIDNOUR, L.; JUNQUEIRA, M. S.; CHAMMAS, R.; WINK, D.; TORTELLI, T. C.; RANGEL, M.
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