LIM/43 - Laboratório de Medicina Nuclear

O Laboratório de Medicina Nuclear é ligado ao Departamento de Radiologia e Oncologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: análise crítica dos métodos de neuroimagem funcional na avaliação das desordens neurológicas e psiquiátricas; medicina nuclear e aplicação clínica dos radioisótopos.

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Recent Submissions

  1. Physical exercise protects against mitochondria alterations in the 6-hidroxydopamine rat model of Parkinson's disease

    BEHAVIOURAL BRAIN RESEARCH, v.387, article ID 112607, 11p, 2020

    Parkinson's disease (PD) is typicaly caractherized by loss of dopaminergic neurons, as well as the presence of mitochondrial impairments. Although physical exercise is known to promote many beneficial effects in healthy subjects, such as enhancing mitocondrial biogenesis and function, it is not c...

  2. Neuroplasticity induced by the retention period of a complex motor skill learning in rats

    BEHAVIOURAL BRAIN RESEARCH, v.414, article ID 113480, 11p, 2021

    Learning complex motor skills is an essential process in our daily lives. Moreover, it is an important aspect for the development of therapeutic strategies that refer to rehabilitation processes since motor skills previously acquired can be transferred to similar tasks (motor skill transfer) or r...

  3. What's behind Ga-68-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns


    Purpose Prostate-specific membrane antigen (PSMA-) PET has become a promising tool in staging and restaging of prostate carcinoma (PCa). However, specific primary tumour features might impact accuracy of PSMA-PET for PCa detection. We investigated histopathological parameters and immunohistochemi...

  4. Metabolic and Structural Signatures of Speech and Language Impairment in Corticobasal Syndrome: A Multimodal PET/MRI Study

    FRONTIERS IN NEUROLOGY, v.12, article ID 702052, 12p, 2021

    Introduction: Corticobasal syndrome (CBS) is a progressive neurological disorder related to multiple underlying pathologies, including four-repeat tauopathies, such as corticobasal degeneration and progressive supranuclear palsy, and Alzheimer's disease (AD). Speech and language are commonly impa...

  5. Deficits in short-term memory binding are detectable in individuals with brain amyloid deposition in the absence of overt neurodegeneration in the Alzheimer's disease continuum

    BRAIN AND COGNITION, v.152, article ID 105749, 9p, 2021

    The short-term memory binding (STMB) test involves the ability to hold in memory the integration between surface features, such as shapes and colours. The STMB test has been used to detect Alzheimer's disease (AD) at different stages, from preclinical to dementia, showing promising results. The o...

  6. Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial

    CLINICAL NUTRITION, v.40, n.8, p.4849-4858, 2021

    Background: Sarcopenia plays a central role in the development of frailty syndrome. Nutrition and exercise are cornerstone strategies to mitigate the transition to frailty; however, there is a paucity of evidence for which dietary and exercise strategies are effective. Objective: This large, mult...

  7. Frequency Domain Repercussions of Instantaneous Granger Causality

    ENTROPY, v.23, n.8, article ID 1037, 15p, 2021

    Using directed transfer function (DTF) and partial directed coherence (PDC) in the information version, this paper extends the theoretical framework to incorporate the instantaneous Granger causality (iGC) frequency domain description into a single unified perspective. We show that standard vecto...

  8. F-18-NaF uptake in dentomaxillofacial bones as a result of oral alterations: a positron emission tomography/computerized tomography scanning study

    ORAL RADIOLOGY, v.37, n.4, p.669-676, 2021

    Objectives F-18-NaF is a bone scanning radiotracer that reflects changes in bone metabolism, and it is applied in oncology to scan bone tumors or metastasis. Dentomaxillofacial alterations can lead to F-18-NaF uptake and could lead to false-positive results in PET/CT examinations. Hence, the obje...

  9. Diagnostic performance of Ga-68-PSMA-11 PET/MRI-guided biopsy in patients with suspected prostate cancer: a prospective single-center study


    Purpose Ultrasound-guided biopsy (US biopsy) with 10-12 cores has a suboptimal sensitivity for clinically significant prostate cancer (sigPCa). If US biopsy is negative, magnetic resonance imaging (MRI)-guided biopsy is recommended, despite a low specificity for lesions with score 3-5 on Prostate...

  10. Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial

    FRONTIERS IN IMMUNOLOGY, v.12, article ID 705250, 10p, 2021

    Introduction: Childhood-onset Takayasu Arteritis (c-TA) is a rare, large-vessel vasculitis seen in children that could predisposing patients to a high risk of mortality. Exercise has the potential to improve overall health in several diseases, but evidence remains scant in c-TA. The main objectiv...