LIM/45 - Laboratório de Neurologia Translacional

URI Permanente desta comunidade

https://observatorio.fm.usp.br/handle/OPI/3774
O Laboratório de Neurologia Translacional é ligado ao Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP).

Linhas de pesquisa: regeneração do sistema nervoso central; terapia celular; neurologia experimental; neurocirurgia funcional; neuropatias neurocirúrgicas; tumores do sistema nervoso; base do crânio; más-formações craniofaciais; doença de Parkinson e distúrbios do sistema extrapiramidal.

Site oficial: http://limhc.fm.usp.br/portal/lim45-laboratorio-de-neurologia-translacional/

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Chronic subdural hematoma drainage using anti-thrombotic catheter technique
(2023) CORDEIRO, J. G.; MONACO, B. Assumpcao de; BENVENISTE, R.; ALKHACHROUM, A.; KRUEGER, E. M.; O'PHELAN, K.; JAGID, J. R.
Background: Burr hole evacuation is a well-established treatment for symptomatic cases with chronic subdural hematoma (cSDH). Routinely postoperative catheter is left in the subdural space to drain the residual blood. Drainage obstruction is commonly seen, and it can be related to suboptimal treatment. Methods: Two groups of patients submitted to cSDH surgery were evaluated in a retrospective non-randomized trial, one group that had conventional subdural drainage (CD group, n ​= ​20) and another group that used an anti-thrombotic catheter (AT group, n ​= ​14). We compared the obstruction rate, amount of drainage and complications. Statistical analyses were done using SPSS (v.28.0). Results: For AT and CD groups respectively (median ​± ​IQR), the age was 68.23 ​± ​26.0 and 70.94 ​± ​21.5 (p ​> ​0.05); preoperative hematoma width was 18.3 ​± ​11.0 ​mm and 20.7 ​± ​11.7 ​mm and midline shift was 13.0 ​± ​9.2 and 5.2 ​± ​8.0 ​mm (p ​= ​0.49). Postoperative hematoma width was 12.7 ​± ​9.2 ​mm and 10.8 ​± ​9.0 ​mm (p ​< ​0.001 intra-groups compared to preoperative) and MLS was 5.2 ​± ​8.0 ​mm and 1.5 ​± ​4.3 ​mm (p ​< ​0.05 intra-groups). There were no complications related to the procedure including infection, bleed worsening and edema. No proximal obstruction was observed on the AT, but 8/20 (40%) presented proximal obstruction on the CD group (p ​= ​0.006). Daily drainage rates and length of drainage were higher in AT compared to CD: 4.0 ​± ​1.25 days vs. 3.0 ​± ​1.0 days (p ​< ​0.001) and 69.86 ​± ​106.54 vs. 35.00 ​± ​59.67 ​mL/day (p ​= ​0.074). Symptomatic recurrence demanding surgery occurred in two patients of CD group (10%) and none in AT group (p ​= ​0.230), after adjusting for MMA embolization, there was still no difference between groups (p ​= ​0.121). Conclusion: The anti-thrombotic catheter for cSDH drainage presented significant less proximal obstruction than the conventional one and higher daily drainage rates. Both methods demonstrated to safe and effective for draining cSDH.
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Discriminating MS from MOGAD using deep learning attention maps
(2023) CORTESE, Rosa; BATTAGLINI, Marco; SFORAZZINI, Francesco; FRANCH, Natalia Cantavella; PRADOS, Ferran; BIANCHI, Alessia; HAIDER, Lukas; JACOB, Anu; PALACE, Jacqueline; MESSINA, Silvia; PAUL, Friedemann; MARIGNIER, Romain; DURAND-DUBIEF, Francoise; RIMKUS, Carolina de Medeiros; CALLEGARO, Dagoberto; SATO, Douglas; FILIPPI, Massimo; ROCCA, Maria Assunta; CACCIAGUERRA, Laura; CANELLAS, Alex Rovira; SASTRE-GARRIGA, Jaume; ARRAMBIDE, Georgina; LIU, Yaou; YUN, Duan; GASPERINI, Claudio; TORTORELLA, Carla; RUGGIERI, Serena; AMATO, Maria Pia; ULIVELLI, Monica; GROPPA, Sergiu; GROTHE, Matthias; LLUFRIU, Sara; SEPULVEDA, Maria; LUKAS, Carsten; BELLENBERG, Barbara; SCHNEIDER, Ruth; SOWA, Piotr; CELIUS, Elisabeth; PROBSTEL, Anne-Katrin; GRANZIERA, Cristina; YALDIZLI, Ozgur; MULLER, Jannis; STANKOFF, Bruno; BODINI, Benedetta; BARKHOF, Frederik; CICCARELLI, Olga; STEFANO, Nicola De
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Paediatric mogad, ms and aqp4-igg+nmosd associated with ethnical gradient in brazil
(2023) COSTA, Bruna Klein da; SOMMER, Rafael Canani; PINTO, Paula de Oliveira; BARROSO, Paula; FERNANDA, Quadros; RIBEIRO, Marlise de Castro; PAOLILO, Renata; CAVALLI, Hanaie; NIHI, Marco Antonio; SATO, Henry Koiti; FRAGOMENI, Manuela; FRAGOSO, Vanessa; FERREIRA, Maria Lucia Brito; SATO, Douglas
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Factors Associated with Hemorrhagic Progression of Cerebral Contusion After Traumatic Brain Injury: A Multicenter Study
(2022) LIMA, Leonardo R.; SOLLA, Davi; PASSOS, George; BRANDAO, Marcio; RAMOS, Camilla; ANDRADE, Mariana; ANDRADE, Almir; COSTA, Roberta; PAIVA, Wellingson; PIASON, Lucas; ROSSETI, Adroaldo
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New insights into structural and functional evaluation of the retina and optic nerve in Parkinson's disease
(2023) MELLO, Luiz Marchesi; PARAGUAY, Isabela Bezerra; ANDRADE, Thais; ROCHA, Arthur do Nascimento; BARBOSA, Egberto; OYAMADA, Maria; MONTEIRO, Mario
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