Low bone mineral density among HIV-infected patients in Brazil
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Citações na Scopus
8
Tipo de produção
article
Data de publicação
2017
Título da Revista
ISSN da Revista
Título do Volume
Editora
INST MEDICINA TROPICAL SAO PAULO
Autores
CHABA, Daniela Cardeal da Silva
SOARES, Lismeia R.
RUTHERFORD, George W.
Citação
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.59, article ID UNSP e89, 5p, 2017
Resumo
Decrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in Sao Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from patients' medical records and BMD was measured by dual-energy X-ray absorptiometry (DXA). Median age of participants was 42 years (interquartile range [IQR] 36-48 years), and the median time since HIV diagnosis was 4.01 years (IQR 2-11 years). Patients had acquired HIV primarily by the sexual route (men who have sex with men 44%, heterosexual 49%). Median age, duration of HIV infection, duration of ART and CD4 nadir were similar for men and women. Plasma viral load was undetectable for 53 patients (49%). Median CD4 T cell count was 399 cells/mu L (IQR 247 - 568). Twenty five patients (23%) had LBMD, and there was no statistically significant difference between men and women (<-1). The associated risk factors for LBMD were older age (>= 50 years old) and smoking with a RR of 3.87 and 2.80, respectively. Thus, despite the lack of statistically significant relationship between the use of ART and LBMD or between duration of ART and LBMD, these factors should be addressed in larger studies.
Palavras-chave
HIV, Bone mineral, Osteoporosis, Risk factors
Referências
- Alcalde R, 2012, VIROL J, V9, DOI 10.1186/1743-422X-9-156
- Araújo Denizar Vianna, 2005, Arq Bras Endocrinol Metab, V49, P897, DOI 10.1590/S0004-27302005000600007
- Baim S, 2008, J CLIN DENSITOM, V11, P75, DOI 10.1016/j.jocd.2007.12.007
- Bonjoch A, 2010, AIDS, V24, P2827, DOI 10.1097/QAD.0b013e328340a28d
- Bortolon PC, 2011, CAD SAUDE PUBLICA, V27, P733, DOI 10.1590/S0102-311X2011000400012
- Bow CH, 2011, OSTEOPOROSIS INT, V22, P2799, DOI 10.1007/s00198-010-1490-0
- Brown TT, 2007, AIDS, V21, P1830, DOI 10.1097/QAD.0b013e3282703837
- Brown TT, 2006, AIDS, V20, P2165, DOI 10.1097/QAD.0b013e32801022eb
- Casseb J, 2012, REV INST MED TROP SP, V54, P257, DOI 10.1590/S0036-46652012000500004
- Cazanave C, 2008, AIDS, V22, P395, DOI 10.1097/QAD.0b013e3282f423dd
- Chitu-Tisu C. E., 2016, GERMS, V6, P50
- Cotter AG, 2014, AIDS, V28, P2051, DOI 10.1097/QAD.0000000000000353
- Eleftheriou KI, 2013, BONE, V52, P17, DOI 10.1016/j.bone.2012.09.003
- Grinsztejn B, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059768
- Jones S, 2008, OSTEOPOROSIS INT, V19, P913, DOI 10.1007/s00198-007-0524-8
- Langkilde A, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0051698
- Malta M, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-1530-y
- Nunn AS, 2007, PLOS MED, V4, P1804, DOI 10.1371/journal.pmed.0040305
- Neto LFSP, 2011, J CLIN DENSITOM, V14, P434, DOI 10.1016/j.jocd.2011.06.004
- Sales SH, 2015, SCI REP-UK, V5, DOI 10.1038/srep12990
- Schafer JJ, 2013, PHARMACOTHERAPY, V33, P665, DOI 10.1002/phar.1257
- Soares LR, 2015, REV INST MED TROP SP, V57, P105, DOI 10.1590/S0036-46652015000200002
- Yin M, 2005, OSTEOPOROSIS INT, V16, P1345, DOI 10.1007/s00198-005-1845-0
- Yong MK, 2011, JAIDS-J ACQ IMM DEF, V57, P205, DOI 10.1097/QAI.0b013e31821ecf4c
- Young B, 2011, CLIN INFECT DIS, V52, P1061, DOI 10.1093/cid/ciq242
- Zhang N, 2016, BIOSCI TRENDS, V10, P277, DOI 10.5582/bst.2016.01081
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - LIM/38
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/17
Artigos e Materiais de Revistas Científicas - LIM/38