Technical challenges of working with extracellular vesicles

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art_RAMIREZ_Technical_challenges_of_working_with_extracellular_vesicles_2018.PDF (1.23 MB)
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367
Tipo de produção
article
Data de publicação
2018
Editora
ROYAL SOC CHEMISTRY
DOI
Indexadores
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Autores
RAMIREZ, Marcel I.
AMORIM, Maria G.
GADELHA, Catarina
MILIC, Ivana
WELSH, Joshua A.
FREITAS, Vanessa M.
NAWAZ, Muhammad
AKBAR, Naveed
COUCH, Yvonne
MAKIN, Laura
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
NANOSCALE, v.10, n.3, p.881-906, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with potential applications in diagnosis, prognosis and therapeutic guidance in most pathological conditions. These nano-sized particles transmit signals determined by their protein, lipid, nucleic acid and sugar content, and the unique molecular pattern of EVs dictates the type of signal to be transmitted to recipient cells. However, their small sizes and the limited quantities that can usually be obtained from patient-derived samples pose a number of challenges to their isolation, study and characterization. These challenges and some possible options to overcome them are discussed in this review.
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https://observatorio.fm.usp.br/handle/OPI/29606
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - LIM/27