Oxytocin and Gynecomastia: Correlation or Causality?

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art_AMORIM_Oxytocin_and_Gynecomastia_Correlation_or_Causality_2018.PDF (754.59 KB)
Citações na Scopus
Tipo de produção
article
Data de publicação
2018
DOI
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CUREUS INC
Autores
GOUVEIA, Flavia V.
GERMANN, Jurgen
ZAMBORI, Debora
MARTINEZ, Raquel
Citação
CUREUS, v.10, n.5, article ID UNSP e2661, 8p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Oxytocin has been administered to patients with autism spectrum disorder (ASD) in order to improve social skills, communication, and manage repetitive behaviors in the context of research trials. The majority of the studies focus on acute administration; thus, the effectiveness and potential side effects of chronic administration remain unknown. The main goal of this case report is to highlight the importance of the safety parameters for the chronic use of intranasal oxytocin administration. In a single case conducted in our outpatient clinic, one adolescent (15 years old) received intranasal oxytocin (24 IU) twice per day, in accordance with the recommended doses for this age group that varies from 8 - 25 IU twice per day. After three weeks of treatment, the patient presented with gynecomastia. While it is not certain that the gynecomastia was oxytocin-induced, this case highlights the importance of developing optimal regimens for chronic oxytocin administration, with a particular focus on safety parameters.
Palavras-chave
oxytocin, chronic administration, autism, gynecomastia, side effects
URI
https://observatorio.fm.usp.br/handle/OPI/30010
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21