Maternal allergen immunization in mice: Prevention of offspring early allergen sensitization
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conferenceObject
Data de publicação
2013
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Editora
W B SAUNDERS CO LTD
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Citação
PLACENTA, v.34, n.2, p.A17-A17, 2013
Resumo
Background: Previously we have been observed that pre-conceptional maternal immunization to OVA is able to prevent the development of allergy in mice. Methods: Female mice were immunized with OVA and mated with normal males. Offspring were evaluated at 3 days old (d.o.) or immunized with OVA and evaluated at 20 d.o. Results: Maternal immunization up-regulated the expression of FcγRIIb on offspring B cells at 3 and 20 d.o. Serum analysis revealed a down regulation on offspring IL-6 levels. Newborns show similar levels of TCD4+ cells producing IL-10, IL-17, IFN-γ or IL-4. Offspring from immune-mothers shows augmented IL-10+ and IL-17+ B cell levels. After offspring immunization we observed higher levels of IL-17+ and IFN-γ+ TCD4+ cells and IL-17+ and IFN-γ+ B cells of offspring from immune mothers. Conclusion: We confirmed the up-regulation of FcγRIIb on offspring B cells, and the augmented IL-10+ B cells on offspring suggest Breg cells involvement. The role of IL-17 must be investigated.