Imatinib-induced fulminant liver failure in chronic myeloid leukemia: Role of liver transplant and second-generation tyrosine kinase inhibitors: A case report

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Citações na Scopus
8
Tipo de produção
article
Data de publicação
2018
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ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD.
Citação
JOURNAL OF MEDICAL CASE REPORTS, v.12, n.1, article ID 63, p, 2018
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Resumo
Background: There is a worldwide problem of acute liver failure and mortality associated with remaining on the waiting for a liver transplant. In this study, we highlight results published in recent years by leading transplant centers in evaluating imatinib-induced acute liver failure in chronic myeloid leukemia and follow-up in liver transplantation. Case presentation: A 36-year-old brown-skinned woman (mixed Brazilian race) diagnosed 1 year earlier with chronic myeloid leukemia was started after delivery of a baby and continued for 6 months with imatinib mesylate (selective inhibitor of Bcr-Abl tyrosine kinase), which induced liver failure. We conducted a literature review using the PubMed database for articles published through September 2017, and we demonstrate a role of liver transplant in this situation for imatinib-induced liver failure. We report previously published results and a successful liver transplant after acute liver failure due to imatinib-induced in chronic myeloid leukemia treatment. Conclusions: We report a case of a successful liver transplant after acute liver failure resulting from imatinib-induced chronic myeloid leukemia treatment. The literature reveals the importance of prompt acute liver failure diagnosis and treatment with liver transplant in selected cases. © 2018 The Author(s).
Palavras-chave
Acute liver failure, Liver transplantation, Organ graft, Transplantation
Referências
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